Zinc in PDB 7uhn: Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (300 Ms Snapshot)

All present enzymatic activity of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (300 Ms Snapshot):
3.5.2.6;

The structure of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (300 Ms Snapshot), PDB code: 7uhn was solved by M.Wilamowski, Y.Kim, D.A.Sherrell, A.Lavens, R.Henning, N.Maltseva, M.Endres, G.Babnigg, V.Srajer, A.Joachimiak, Center For Structuralgenomics Of Infectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.03 / 2.20
Space group	P 64 2 2
Cell size a, b, c (Å), α, β, γ (°)	105.853, 105.853, 99.1, 90, 90, 120
R / Rfree (%)	19.9 / 24.6

The binding sites of Zinc atom in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (300 Ms Snapshot) (pdb code 7uhn). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (300 Ms Snapshot), PDB code: 7uhn:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (300 Ms Snapshot)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (300 Ms Snapshot) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:21.4 occ:0.60 ND1 A:HIS107 2.2 14.8 1.0 O10 A:XQP303 2.3 32.6 0.7 NE2 A:HIS105 2.5 14.7 1.0 NE2 A:HIS181 2.6 18.0 1.0 CG A:HIS107 3.1 11.0 1.0 ZN A:ZN302 3.2 23.4 0.5 CD2 A:HIS105 3.3 11.9 1.0 CE1 A:HIS107 3.3 9.3 1.0 CB A:HIS107 3.3 9.2 1.0 CD2 A:HIS181 3.3 12.1 1.0 C1 A:XQP303 3.4 34.5 0.7 CE1 A:HIS105 3.6 12.9 1.0 O3 A:XQP303 3.6 30.7 0.7 N1 A:XQP303 3.7 31.8 0.7 OD1 A:ASP109 3.7 16.9 1.0 CE1 A:HIS181 3.7 19.2 1.0 C7 A:XQP303 3.9 29.9 0.7 C6 A:XQP303 3.9 34.6 0.7 C5 A:XQP303 4.1 32.1 0.7 O8 A:XQP303 4.2 30.8 0.7 OD2 A:ASP109 4.2 20.1 1.0 CD2 A:HIS110 4.2 14.2 1.0 CD2 A:HIS107 4.3 9.8 1.0 CG A:ASP109 4.3 15.7 1.0 NE2 A:HIS110 4.3 20.3 1.0 NE2 A:HIS107 4.3 9.0 1.0 O1 A:XQP303 4.5 36.8 0.7 CG A:HIS105 4.5 8.0 1.0 CG A:HIS181 4.6 10.1 1.0 ND1 A:HIS105 4.6 10.5 1.0 ND1 A:HIS181 4.7 16.6 1.0 C2 A:XQP303 4.8 31.7 0.7 CA A:HIS107 4.8 9.0 1.0 C20 A:XQP303 4.9 31.2 0.7

Zinc binding site 2 out of 2 in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (300 Ms Snapshot)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (300 Ms Snapshot) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn302 b:23.4 occ:0.52 OD2 A:ASP109 2.1 20.1 1.0 N1 A:XQP303 2.3 31.8 0.7 NE2 A:HIS110 2.3 20.3 1.0 NE2 A:HIS246 2.6 18.8 1.0 C5 A:XQP303 2.9 32.1 0.7 C2 A:XQP303 3.0 31.7 0.7 CG A:ASP109 3.1 15.7 1.0 CD2 A:HIS110 3.2 14.2 1.0 ZN A:ZN301 3.2 21.4 0.6 CD2 A:HIS246 3.2 20.4 1.0 CE1 A:HIS110 3.3 16.6 1.0 C20 A:XQP303 3.4 31.2 0.7 O8 A:XQP303 3.5 30.8 0.7 OD1 A:ASP109 3.5 16.9 1.0 CE1 A:HIS246 3.8 23.7 1.0 O10 A:XQP303 3.8 32.6 0.7 C6 A:XQP303 3.9 34.6 0.7 O2 A:XQP303 3.9 34.9 0.7 NE2 A:HIS105 4.1 14.7 1.0 C3 A:XQP303 4.1 34.9 0.7 O3 A:XQP303 4.1 30.7 0.7 O9 A:XQP303 4.1 31.2 0.7 C1 A:XQP303 4.2 34.5 0.7 CE1 A:HIS105 4.3 12.9 1.0 CG A:HIS110 4.4 15.1 1.0 ND1 A:HIS110 4.4 14.6 1.0 CB A:ASP109 4.5 14.2 1.0 NE2 A:HIS181 4.5 18.0 1.0 CG A:HIS246 4.5 16.6 1.0 C4 A:XQP303 4.6 37.5 0.7 ND1 A:HIS246 4.8 17.9 1.0

M.Wilamowski, Y.Kim, D.A.Sherrell, A.Lavens, R.Henning, N.Maltseva, M.Endres, G.Babnigg, V.Srajer, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid). Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (300 Ms Snapshot) To Be Published.