Zinc in PDB 9jej: Crystal Structure of Human EP300 Kix Domain (L644C Mutant)

All present enzymatic activity of Crystal Structure of Human EP300 Kix Domain (L644C Mutant):
2.3.1.48;

The structure of Crystal Structure of Human EP300 Kix Domain (L644C Mutant), PDB code: 9jej was solved by B.I.Lee, S.E.Cho, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	31.26 / 2.90
Space group	I 4 2 2
Cell size a, b, c (Å), α, β, γ (°)	96.342, 96.342, 136.256, 90, 90, 90
R / Rfree (%)	25.1 / 28.1

The binding sites of Zinc atom in the Crystal Structure of Human EP300 Kix Domain (L644C Mutant) (pdb code 9jej). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human EP300 Kix Domain (L644C Mutant), PDB code: 9jej:

Zinc binding site 1 out of 1 in the Crystal Structure of Human EP300 Kix Domain (L644C Mutant)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human EP300 Kix Domain (L644C Mutant) within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn701 b:66.6 occ:1.00 NE2 C:HIS582 3.5 56.5 1.0 NE2 A:HIS582 3.5 50.6 1.0 NE2 B:HIS582 3.5 49.0 1.0 NZ A:LYS586 3.9 57.3 1.0 NZ C:LYS586 4.0 55.8 1.0 NZ B:LYS586 4.1 47.2 1.0 CD A:LYS586 4.1 45.2 1.0 CE A:LYS586 4.2 50.2 1.0 CD C:LYS586 4.2 45.7 1.0 CE1 B:HIS582 4.2 42.1 1.0 CD B:LYS586 4.2 43.1 1.0 CE1 C:HIS582 4.3 44.2 1.0 CE1 A:HIS582 4.3 42.9 1.0 CE C:LYS586 4.3 50.2 1.0 CE B:LYS586 4.3 46.5 1.0 CD2 C:HIS582 4.5 43.7 1.0 CD2 A:HIS582 4.6 42.5 1.0 CD2 B:HIS582 4.6 41.5 1.0

S.E.Cho, Y.Lee, J.I.Kim, K.Y.Jung, H.Jeong, H.W.Park, B.I.Lee. Comparative Crystal Structure Analysis of the Human EP300 and Cbp Kix Domains. Biochem.Biophys.Res.Commun. V. 741 51064 2024.
ISSN: ESSN 1090-2104
PubMed: 39612645
DOI: 10.1016/J.BBRC.2024.151064