Zinc in PDB 9dzn: KAT6A Myst Domain Complexed with A H3K14-Coa Bisubstrate Inhibitor

All present enzymatic activity of KAT6A Myst Domain Complexed with A H3K14-Coa Bisubstrate Inhibitor:
2.3.1.48;

The structure of KAT6A Myst Domain Complexed with A H3K14-Coa Bisubstrate Inhibitor, PDB code: 9dzn was solved by E.Johnson, S.Greasley, O.Brodsky, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	57.13 / 1.72
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	59.368, 59.368, 210.05, 90, 90, 90
R / Rfree (%)	21.9 / 24.5

The binding sites of Zinc atom in the KAT6A Myst Domain Complexed with A H3K14-Coa Bisubstrate Inhibitor (pdb code 9dzn). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the KAT6A Myst Domain Complexed with A H3K14-Coa Bisubstrate Inhibitor, PDB code: 9dzn:

Zinc binding site 1 out of 1 in the KAT6A Myst Domain Complexed with A H3K14-Coa Bisubstrate Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of KAT6A Myst Domain Complexed with A H3K14-Coa Bisubstrate Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn801 b:27.8 occ:1.00 NE2 A:HIS556 2.1 35.9 1.0 SG A:CYS543 2.2 30.4 1.0 SG A:CYS560 2.3 30.2 1.0 SG A:CYS540 2.3 24.7 1.0 CE1 A:HIS556 3.0 36.5 1.0 CD2 A:HIS556 3.1 34.6 1.0 CB A:CYS540 3.2 24.1 1.0 CB A:CYS543 3.2 26.7 1.0 CB A:CYS560 3.3 27.4 1.0 N A:CYS543 3.8 24.1 1.0 CA A:CYS543 4.1 24.8 1.0 ND1 A:HIS556 4.2 36.1 1.0 CG A:HIS556 4.2 34.1 1.0 CA A:CYS560 4.5 27.7 1.0 CA A:CYS540 4.7 24.1 1.0 SD A:MET557 4.8 30.7 1.0 C A:PHE542 4.8 24.0 1.0 C A:CYS543 4.9 24.1 1.0 O A:HOH948 5.0 37.5 1.0

R.N.Sengupta, O.Brodsky, P.Bingham, W.C.Diehl, R.Ferre, S.E.Greasley, E.Johnson, M.Kraus, W.Lieberman, J.L.Meier, T.A.Paul, K.A.Maegley. Modulation of the Substrate Preference of A Myst Acetyltransferase By A Scaffold Protein. J.Biol.Chem. 08262 2025.
ISSN: ESSN 1083-351X
PubMed: 39909374
DOI: 10.1016/J.JBC.2025.108262