Zinc in PDB 7uhm: Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (150 Ms Snapshot)

All present enzymatic activity of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (150 Ms Snapshot):
3.5.2.6;

The structure of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (150 Ms Snapshot), PDB code: 7uhm was solved by M.Wilamowski, Y.Kim, D.A.Sherrell, A.Lavens, R.Henning, N.Maltseva, M.Endres, G.Babnigg, V.Srajer, A.Joachimiak, Center For Structuralgenomics Of Infectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.65 / 2.70
Space group	P 64 2 2
Cell size a, b, c (Å), α, β, γ (°)	105.853, 105.853, 99.1, 90, 90, 120
R / Rfree (%)	23.5 / 29

The binding sites of Zinc atom in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (150 Ms Snapshot) (pdb code 7uhm). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (150 Ms Snapshot), PDB code: 7uhm:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (150 Ms Snapshot)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (150 Ms Snapshot) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:5.9 occ:0.48 ND1 A:HIS107 2.1 20.9 1.0 NE2 A:HIS105 2.3 12.6 1.0 O10 A:XQP303 2.5 22.7 0.8 NE2 A:HIS181 2.7 22.9 1.0 CG A:HIS107 3.0 24.1 1.0 CE1 A:HIS107 3.2 12.8 1.0 CB A:HIS107 3.2 12.7 1.0 CD2 A:HIS105 3.2 12.6 1.0 CE1 A:HIS105 3.3 12.6 1.0 CD2 A:HIS181 3.4 22.8 1.0 ZN A:ZN302 3.4 17.8 0.9 C1 A:XQP303 3.6 23.4 0.8 CE1 A:HIS181 3.7 23.3 1.0 CD2 A:HIS110 3.7 28.0 1.0 OD1 A:ASP109 3.8 19.0 1.0 O3 A:XQP303 3.9 24.3 0.8 NE2 A:HIS110 4.0 26.4 1.0 C7 A:XQP303 4.1 23.6 0.8 CD2 A:HIS107 4.1 24.2 1.0 NE2 A:HIS107 4.2 12.9 1.0 N1 A:XQP303 4.3 26.1 0.8 C6 A:XQP303 4.3 25.1 0.8 CG A:HIS105 4.3 13.8 1.0 ND1 A:HIS105 4.3 12.6 1.0 O8 A:XQP303 4.6 28.1 0.8 CG A:HIS181 4.6 21.7 1.0 O1 A:XQP303 4.6 22.6 0.8 CA A:HIS107 4.7 12.7 1.0 ND1 A:HIS181 4.7 22.9 1.0 CG A:ASP109 4.7 18.1 1.0 C5 A:XQP303 4.7 25.9 0.8 OD2 A:ASP109 4.8 18.9 1.0

Zinc binding site 2 out of 2 in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (150 Ms Snapshot)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (150 Ms Snapshot) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn302 b:17.8 occ:0.86 NE2 A:HIS110 2.1 26.4 1.0 N1 A:XQP303 2.4 26.1 0.8 OD2 A:ASP109 2.6 18.9 1.0 CE1 A:HIS246 2.6 20.2 1.0 O8 A:XQP303 2.9 28.1 0.8 CD2 A:HIS110 3.1 28.0 1.0 CE1 A:HIS110 3.1 28.5 1.0 C5 A:XQP303 3.2 25.9 0.8 C2 A:XQP303 3.3 27.4 0.8 C20 A:XQP303 3.4 28.1 0.8 CG A:ASP109 3.4 18.1 1.0 ZN A:ZN301 3.4 5.9 0.5 OD1 A:ASP109 3.5 19.0 1.0 ND1 A:HIS246 3.5 20.2 1.0 O10 A:XQP303 3.5 22.7 0.8 NE2 A:HIS246 3.5 20.4 1.0 C6 A:XQP303 4.1 25.1 0.8 C1 A:XQP303 4.1 23.4 0.8 O3 A:XQP303 4.1 24.3 0.8 ND1 A:HIS110 4.2 28.1 1.0 CG A:HIS110 4.2 12.6 1.0 NE2 A:HIS105 4.2 12.6 1.0 CE1 A:HIS105 4.2 12.6 1.0 O2 A:XQP303 4.4 27.4 0.8 O9 A:XQP303 4.4 28.4 0.8 OG A:SER206 4.5 18.3 1.0 C3 A:XQP303 4.6 28.0 0.8 CG A:HIS246 4.7 20.2 1.0 CD2 A:HIS246 4.7 20.4 1.0 NE2 A:HIS181 4.7 22.9 1.0 CB A:ASP109 4.9 16.7 1.0 CE1 A:HIS181 4.9 23.3 1.0

M.Wilamowski, Y.Kim, D.A.Sherrell, A.Lavens, R.Henning, N.Maltseva, M.Endres, G.Babnigg, V.Srajer, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid). Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (150 Ms Snapshot) To Be Published.