Zinc in PDB 7e8d: NSD2 E1099K Mutant Bound to Nucleosome

All present enzymatic activity of NSD2 E1099K Mutant Bound to Nucleosome:
2.1.1.357;

The binding sites of Zinc atom in the NSD2 E1099K Mutant Bound to Nucleosome (pdb code 7e8d). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the NSD2 E1099K Mutant Bound to Nucleosome, PDB code: 7e8d:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the NSD2 E1099K Mutant Bound to Nucleosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of NSD2 E1099K Mutant Bound to Nucleosome within 5.0Å range: probe atom residue distance (Å) B Occ K:Zn1301 b:132.1 occ:1.00 SG K:CYS1193 2.3 118.8 1.0 SG K:CYS1191 2.3 118.3 1.0 SG K:CYS1198 2.3 118.8 1.0 SG K:CYS1144 2.3 114.6 1.0 CB K:CYS1198 3.1 118.8 1.0 CB K:CYS1193 3.2 118.8 1.0 CB K:CYS1144 3.5 114.6 1.0 CA K:CYS1198 3.5 118.8 1.0 CB K:CYS1191 3.6 118.3 1.0 O K:CYS1191 3.8 118.3 1.0 N K:CYS1144 3.9 114.6 1.0 N K:SER1199 4.0 116.9 1.0 N K:CYS1193 4.1 118.8 1.0 C K:CYS1198 4.2 118.8 1.0 CA K:CYS1193 4.2 118.8 1.0 CA K:CYS1144 4.4 114.6 1.0 C K:CYS1191 4.4 118.3 1.0 N K:GLY1200 4.5 117.6 1.0 NE2 K:HIS1142 4.6 109.5 1.0 CA K:CYS1191 4.6 118.3 1.0 N K:GLY1194 4.7 118.5 1.0 N K:CYS1198 4.8 118.8 1.0 N K:ALA1195 4.9 119.0 1.0 C K:CYS1193 4.9 118.8 1.0 CB K:ALA1195 4.9 119.0 1.0 CD2 K:HIS1142 5.0 109.5 1.0 O K:PHE1201 5.0 117.9 1.0

Zinc binding site 2 out of 3 in the NSD2 E1099K Mutant Bound to Nucleosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of NSD2 E1099K Mutant Bound to Nucleosome within 5.0Å range: probe atom residue distance (Å) B Occ K:Zn1302 b:98.5 occ:1.00 SG K:CYS1026 2.3 89.9 1.0 SG K:CYS1016 2.3 86.0 1.0 SG K:CYS1018 2.3 92.6 1.0 SG K:CYS1032 2.3 82.0 1.0 CB K:CYS1018 2.9 92.6 1.0 CB K:CYS1026 3.2 89.9 1.0 CB K:CYS1016 3.3 86.0 1.0 CB K:CYS1032 3.3 82.0 1.0 CA K:CYS1026 3.5 89.9 1.0 ZN K:ZN1303 3.8 103.7 1.0 CA K:CYS1032 3.9 82.0 1.0 N K:CYS1026 3.9 89.9 1.0 N K:CYS1018 4.0 92.6 1.0 CA K:CYS1018 4.1 92.6 1.0 SG K:CYS1041 4.1 88.3 1.0 N K:LEU1033 4.6 75.1 1.0 C K:CYS1032 4.7 82.0 1.0 CA K:CYS1016 4.7 86.0 1.0 SG K:CYS1046 4.8 92.3 1.0 C K:CYS1026 4.9 89.9 1.0 N K:ASN1017 4.9 89.8 1.0 C K:PRO1025 5.0 93.5 1.0

Zinc binding site 3 out of 3 in the NSD2 E1099K Mutant Bound to Nucleosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of NSD2 E1099K Mutant Bound to Nucleosome within 5.0Å range: probe atom residue distance (Å) B Occ K:Zn1303 b:103.7 occ:1.00 SG K:CYS1026 2.3 89.9 1.0 SG K:CYS1046 2.3 92.3 1.0 SG K:CYS1041 2.3 88.3 1.0 SG K:CYS1052 2.3 93.5 1.0 CB K:CYS1041 2.8 88.3 1.0 CB K:CYS1026 3.1 89.9 1.0 CB K:CYS1052 3.2 93.5 1.0 CB K:CYS1046 3.4 92.3 1.0 ZN K:ZN1302 3.8 98.5 1.0 SG K:CYS1016 4.1 86.0 1.0 CA K:CYS1052 4.2 93.5 1.0 CB K:ASN1054 4.3 88.4 1.0 CA K:CYS1041 4.3 88.3 1.0 CA K:CYS1026 4.6 89.9 1.0 CA K:CYS1046 4.7 92.3 1.0 SG K:CYS1032 4.7 82.0 1.0 ND2 K:ASN1054 4.8 88.4 1.0 CB K:ALA1048 4.8 93.8 1.0

T.Sengoku, K.Sato, T.Nishizawa, O.Nureki, K.Ogata. NSD2 E1099K Mutant Bound to Nucleosome To Be Published.