Zinc in PDB 7dxg: Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom

The structure of Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom also contains other interesting chemical elements:

Calcium	(Ca)	8 atoms
Chlorine	(Cl)	4 atoms

The binding sites of Zinc atom in the Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom (pdb code 7dxg). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom, PDB code: 7dxg:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:184.6 occ:1.00 SG A:CYS255 2.3 155.2 1.0 ND1 A:HIS249 2.3 136.0 1.0 SG A:CYS258 2.3 152.0 1.0 CB A:CYS258 3.1 143.2 1.0 CE1 A:HIS249 3.2 136.0 1.0 SG A:CYS253 3.3 145.4 1.0 CG A:HIS249 3.3 128.6 1.0 CB A:HIS249 3.7 128.3 1.0 N A:CYS258 3.7 139.6 1.0 CA A:CYS258 3.9 138.9 1.0 CB A:CYS255 4.0 140.1 1.0 CB A:CYS253 4.0 136.4 1.0 NE2 A:HIS249 4.4 134.4 1.0 CD2 A:HIS249 4.4 129.8 1.0 N A:CYS255 4.8 142.5 1.0 C A:ASP257 4.8 137.7 1.0 CA A:CYS255 4.9 142.8 1.0 CB A:ASP257 4.9 143.3 1.0

Zinc binding site 2 out of 4 in the Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1001 b:184.6 occ:1.00 SG B:CYS255 2.3 155.2 1.0 ND1 B:HIS249 2.3 136.0 1.0 SG B:CYS258 2.3 152.0 1.0 CB B:CYS258 3.1 143.2 1.0 CE1 B:HIS249 3.2 136.0 1.0 SG B:CYS253 3.3 145.4 1.0 CG B:HIS249 3.3 128.6 1.0 CB B:HIS249 3.7 128.3 1.0 N B:CYS258 3.7 139.6 1.0 CA B:CYS258 3.9 138.9 1.0 CB B:CYS255 4.0 140.1 1.0 CB B:CYS253 4.0 136.4 1.0 NE2 B:HIS249 4.4 134.4 1.0 CD2 B:HIS249 4.4 129.8 1.0 N B:CYS255 4.8 142.5 1.0 C B:ASP257 4.8 137.7 1.0 CA B:CYS255 4.9 142.8 1.0 CB B:ASP257 4.9 143.3 1.0

Zinc binding site 3 out of 4 in the Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1002 b:184.6 occ:1.00 SG C:CYS255 2.3 155.2 1.0 ND1 C:HIS249 2.3 136.0 1.0 SG C:CYS258 2.3 152.0 1.0 CB C:CYS258 3.1 143.2 1.0 CE1 C:HIS249 3.2 136.0 1.0 SG C:CYS253 3.3 145.4 1.0 CG C:HIS249 3.3 128.6 1.0 CB C:HIS249 3.7 128.3 1.0 N C:CYS258 3.7 139.6 1.0 CA C:CYS258 3.9 138.9 1.0 CB C:CYS255 4.0 140.1 1.0 CB C:CYS253 4.0 136.4 1.0 NE2 C:HIS249 4.4 134.4 1.0 CD2 C:HIS249 4.4 129.8 1.0 N C:CYS255 4.8 142.5 1.0 C C:ASP257 4.8 137.7 1.0 CA C:CYS255 4.9 142.8 1.0 CB C:ASP257 4.9 143.3 1.0

Zinc binding site 4 out of 4 in the Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1002 b:184.6 occ:1.00 SG D:CYS255 2.3 155.2 1.0 ND1 D:HIS249 2.3 136.0 1.0 SG D:CYS258 2.3 152.0 1.0 CB D:CYS258 3.1 143.2 1.0 CE1 D:HIS249 3.2 136.0 1.0 SG D:CYS253 3.3 145.4 1.0 CG D:HIS249 3.3 128.6 1.0 CB D:HIS249 3.7 128.3 1.0 N D:CYS258 3.7 139.6 1.0 CA D:CYS258 3.9 138.9 1.0 CB D:CYS255 4.0 140.1 1.0 CB D:CYS253 4.0 136.4 1.0 NE2 D:HIS249 4.4 134.4 1.0 CD2 D:HIS249 4.4 129.8 1.0 N D:CYS255 4.8 142.5 1.0 C D:ASP257 4.8 137.7 1.0 CA D:CYS255 4.9 142.8 1.0 CB D:ASP257 4.9 143.3 1.0

W.Guo, Q.Tang, M.Wei, Y.Kang, J.X.Wu, L.Chen. Structural Mechanism of Human TRPC3 and TRPC6 Channel Regulation By Their Intracellular Calcium-Binding Sites. Neuron V. 110 1023 2022.
ISSN: ISSN 0896-6273
PubMed: 35051376
DOI: 10.1016/J.NEURON.2021.12.023