Zinc in PDB 7dxf: Structure of Btdm-Bound Human TRPC6 Nanodisc at 2.9 Angstrom in High Calcium State

The structure of Structure of Btdm-Bound Human TRPC6 Nanodisc at 2.9 Angstrom in High Calcium State also contains other interesting chemical elements:

Calcium

(Ca)

12 atoms

The binding sites of Zinc atom in the Structure of Btdm-Bound Human TRPC6 Nanodisc at 2.9 Angstrom in High Calcium State (pdb code 7dxf). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of Btdm-Bound Human TRPC6 Nanodisc at 2.9 Angstrom in High Calcium State, PDB code: 7dxf:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structure of Btdm-Bound Human TRPC6 Nanodisc at 2.9 Angstrom in High Calcium State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Btdm-Bound Human TRPC6 Nanodisc at 2.9 Angstrom in High Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:160.7 occ:1.00 ND1 A:HIS249 2.1 125.1 1.0 SG A:CYS255 2.3 138.8 1.0 SG A:CYS258 2.3 147.2 1.0 SG A:CYS253 2.3 128.3 1.0 CE1 A:HIS249 2.9 123.8 1.0 CB A:CYS258 3.1 127.4 1.0 CG A:HIS249 3.2 121.7 1.0 CB A:CYS255 3.4 125.8 1.0 CB A:CYS253 3.6 121.7 1.0 CB A:HIS249 3.7 115.6 1.0 NE2 A:HIS249 4.1 123.1 1.0 N A:CYS258 4.1 124.0 1.0 N A:CYS255 4.2 122.3 1.0 CA A:CYS258 4.2 124.2 1.0 CD2 A:HIS249 4.3 118.1 1.0 CA A:CYS255 4.3 126.8 1.0 C A:CYS255 4.8 128.9 1.0 CA A:CYS253 4.9 120.0 1.0 O A:CYS255 4.9 128.1 1.0

Zinc binding site 2 out of 4 in the Structure of Btdm-Bound Human TRPC6 Nanodisc at 2.9 Angstrom in High Calcium State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Btdm-Bound Human TRPC6 Nanodisc at 2.9 Angstrom in High Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1001 b:160.7 occ:1.00 ND1 B:HIS249 2.1 125.1 1.0 SG B:CYS255 2.3 138.8 1.0 SG B:CYS258 2.3 147.2 1.0 SG B:CYS253 2.3 128.3 1.0 CE1 B:HIS249 2.9 123.8 1.0 CB B:CYS258 3.1 127.4 1.0 CG B:HIS249 3.2 121.7 1.0 CB B:CYS255 3.4 125.8 1.0 CB B:CYS253 3.6 121.7 1.0 CB B:HIS249 3.7 115.6 1.0 NE2 B:HIS249 4.1 123.1 1.0 N B:CYS258 4.1 124.0 1.0 N B:CYS255 4.2 122.3 1.0 CA B:CYS258 4.2 124.2 1.0 CD2 B:HIS249 4.3 118.1 1.0 CA B:CYS255 4.3 126.8 1.0 C B:CYS255 4.8 128.9 1.0 CA B:CYS253 4.9 120.0 1.0 O B:CYS255 4.9 128.1 1.0

Zinc binding site 3 out of 4 in the Structure of Btdm-Bound Human TRPC6 Nanodisc at 2.9 Angstrom in High Calcium State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of Btdm-Bound Human TRPC6 Nanodisc at 2.9 Angstrom in High Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1001 b:160.7 occ:1.00 ND1 C:HIS249 2.1 125.1 1.0 SG C:CYS255 2.3 138.8 1.0 SG C:CYS258 2.3 147.2 1.0 SG C:CYS253 2.3 128.3 1.0 CE1 C:HIS249 2.9 123.8 1.0 CB C:CYS258 3.1 127.4 1.0 CG C:HIS249 3.2 121.7 1.0 CB C:CYS255 3.4 125.8 1.0 CB C:CYS253 3.6 121.7 1.0 CB C:HIS249 3.7 115.6 1.0 NE2 C:HIS249 4.1 123.1 1.0 N C:CYS258 4.1 124.0 1.0 N C:CYS255 4.2 122.3 1.0 CA C:CYS258 4.2 124.2 1.0 CD2 C:HIS249 4.3 118.1 1.0 CA C:CYS255 4.3 126.8 1.0 C C:CYS255 4.8 128.9 1.0 CA C:CYS253 4.9 120.0 1.0 O C:CYS255 4.9 128.1 1.0

Zinc binding site 4 out of 4 in the Structure of Btdm-Bound Human TRPC6 Nanodisc at 2.9 Angstrom in High Calcium State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of Btdm-Bound Human TRPC6 Nanodisc at 2.9 Angstrom in High Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1003 b:160.7 occ:1.00 ND1 D:HIS249 2.1 125.1 1.0 SG D:CYS255 2.3 138.8 1.0 SG D:CYS258 2.3 147.2 1.0 SG D:CYS253 2.3 128.3 1.0 CE1 D:HIS249 2.9 123.8 1.0 CB D:CYS258 3.1 127.4 1.0 CG D:HIS249 3.2 121.7 1.0 CB D:CYS255 3.4 125.8 1.0 CB D:CYS253 3.6 121.7 1.0 CB D:HIS249 3.7 115.6 1.0 NE2 D:HIS249 4.1 123.1 1.0 N D:CYS258 4.1 124.0 1.0 N D:CYS255 4.2 122.3 1.0 CA D:CYS258 4.2 124.2 1.0 CD2 D:HIS249 4.3 118.1 1.0 CA D:CYS255 4.3 126.8 1.0 C D:CYS255 4.8 128.9 1.0 CA D:CYS253 4.9 120.0 1.0 O D:CYS255 4.9 128.1 1.0

W.Guo, Q.Tang, M.Wei, Y.Kang, J.X.Wu, L.Chen. Structural Mechanism of Human TRPC3 and TRPC6 Channel Regulation By Their Intracellular Calcium-Binding Sites. Neuron V. 110 1023 2022.
ISSN: ISSN 0896-6273
PubMed: 35051376
DOI: 10.1016/J.NEURON.2021.12.023