Zinc in PDB 7dxe: Structure of TRPC3 Gain of Function Mutation R803C at 3.2 Angstrom in 1340NM Free Calcium State

The binding sites of Zinc atom in the Structure of TRPC3 Gain of Function Mutation R803C at 3.2 Angstrom in 1340NM Free Calcium State (pdb code 7dxe). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of TRPC3 Gain of Function Mutation R803C at 3.2 Angstrom in 1340NM Free Calcium State, PDB code: 7dxe:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structure of TRPC3 Gain of Function Mutation R803C at 3.2 Angstrom in 1340NM Free Calcium State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of TRPC3 Gain of Function Mutation R803C at 3.2 Angstrom in 1340NM Free Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn902 b:206.2 occ:1.00 ND1 D:HIS178 2.1 189.5 1.0 SG D:CYS187 2.4 178.8 1.0 SG D:CYS184 2.4 186.4 1.0 SG D:CYS182 2.4 188.2 1.0 CG D:HIS178 2.9 177.6 1.0 CE1 D:HIS178 2.9 190.9 1.0 CB D:CYS187 3.2 177.4 1.0 CB D:HIS178 3.3 163.8 1.0 CB D:CYS182 3.4 167.4 1.0 CB D:CYS184 3.6 178.8 1.0 CD2 D:HIS178 3.9 175.8 1.0 NE2 D:HIS178 3.9 188.2 1.0 N D:CYS187 4.2 174.1 1.0 CA D:CYS187 4.3 172.1 1.0 N D:CYS184 4.3 170.2 1.0 CA D:CYS184 4.5 171.2 1.0 CA D:CYS182 4.7 162.5 1.0 CA D:HIS178 4.8 154.0 1.0 C D:CYS182 4.8 165.4 1.0 O D:CYS184 5.0 177.9 1.0

Zinc binding site 2 out of 4 in the Structure of TRPC3 Gain of Function Mutation R803C at 3.2 Angstrom in 1340NM Free Calcium State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of TRPC3 Gain of Function Mutation R803C at 3.2 Angstrom in 1340NM Free Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn904 b:206.2 occ:1.00 ND1 A:HIS178 2.1 189.5 1.0 SG A:CYS187 2.4 178.8 1.0 SG A:CYS184 2.4 186.4 1.0 SG A:CYS182 2.4 188.2 1.0 CG A:HIS178 2.9 177.6 1.0 CE1 A:HIS178 2.9 190.9 1.0 CB A:CYS187 3.2 177.4 1.0 CB A:HIS178 3.3 163.8 1.0 CB A:CYS182 3.4 167.4 1.0 CB A:CYS184 3.6 178.8 1.0 CD2 A:HIS178 3.9 175.8 1.0 NE2 A:HIS178 3.9 188.2 1.0 N A:CYS187 4.2 174.1 1.0 CA A:CYS187 4.3 172.1 1.0 N A:CYS184 4.3 170.2 1.0 CA A:CYS184 4.5 171.2 1.0 CA A:CYS182 4.7 162.5 1.0 CA A:HIS178 4.8 154.0 1.0 C A:CYS182 4.8 165.4 1.0 O A:CYS184 5.0 177.9 1.0

Zinc binding site 3 out of 4 in the Structure of TRPC3 Gain of Function Mutation R803C at 3.2 Angstrom in 1340NM Free Calcium State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of TRPC3 Gain of Function Mutation R803C at 3.2 Angstrom in 1340NM Free Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn902 b:206.2 occ:1.00 ND1 B:HIS178 2.1 189.5 1.0 SG B:CYS187 2.4 178.8 1.0 SG B:CYS184 2.4 186.4 1.0 SG B:CYS182 2.4 188.2 1.0 CG B:HIS178 2.9 177.6 1.0 CE1 B:HIS178 2.9 190.9 1.0 CB B:CYS187 3.2 177.4 1.0 CB B:HIS178 3.3 163.8 1.0 CB B:CYS182 3.4 167.4 1.0 CB B:CYS184 3.6 178.8 1.0 CD2 B:HIS178 3.9 175.8 1.0 NE2 B:HIS178 3.9 188.2 1.0 N B:CYS187 4.2 174.1 1.0 CA B:CYS187 4.3 172.1 1.0 N B:CYS184 4.3 170.2 1.0 CA B:CYS184 4.5 171.2 1.0 CA B:CYS182 4.7 162.5 1.0 CA B:HIS178 4.8 154.0 1.0 C B:CYS182 4.8 165.4 1.0 O B:CYS184 5.0 177.9 1.0

Zinc binding site 4 out of 4 in the Structure of TRPC3 Gain of Function Mutation R803C at 3.2 Angstrom in 1340NM Free Calcium State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of TRPC3 Gain of Function Mutation R803C at 3.2 Angstrom in 1340NM Free Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn904 b:206.2 occ:1.00 ND1 C:HIS178 2.1 189.5 1.0 SG C:CYS187 2.4 178.8 1.0 SG C:CYS184 2.4 186.4 1.0 SG C:CYS182 2.4 188.2 1.0 CG C:HIS178 2.9 177.6 1.0 CE1 C:HIS178 2.9 190.9 1.0 CB C:CYS187 3.2 177.4 1.0 CB C:HIS178 3.3 163.8 1.0 CB C:CYS182 3.4 167.4 1.0 CB C:CYS184 3.6 178.8 1.0 CD2 C:HIS178 3.9 175.8 1.0 NE2 C:HIS178 3.9 188.2 1.0 N C:CYS187 4.2 174.1 1.0 CA C:CYS187 4.3 172.1 1.0 N C:CYS184 4.3 170.2 1.0 CA C:CYS184 4.5 171.2 1.0 CA C:CYS182 4.7 162.5 1.0 CA C:HIS178 4.8 154.0 1.0 C C:CYS182 4.8 165.4 1.0 O C:CYS184 5.0 177.9 1.0

W.Guo, Q.Tang, M.Wei, Y.Kang, J.X.Wu, L.Chen. Structural Mechanism of Human TRPC3 and TRPC6 Channel Regulation By Their Intracellular Calcium-Binding Sites. Neuron V. 110 1023 2022.
ISSN: ISSN 0896-6273
PubMed: 35051376
DOI: 10.1016/J.NEURON.2021.12.023