Zinc in PDB 6xpf: Cryo-Em Structure of Human ZNT8 Wt, in the Absence of Zinc, Determined in Heterogeneous Conformations- One Subunit in An Inward-Facing and the Other in An Outward-Facing Conformation

The binding sites of Zinc atom in the Cryo-Em Structure of Human ZNT8 Wt, in the Absence of Zinc, Determined in Heterogeneous Conformations- One Subunit in An Inward-Facing and the Other in An Outward-Facing Conformation (pdb code 6xpf). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Cryo-Em Structure of Human ZNT8 Wt, in the Absence of Zinc, Determined in Heterogeneous Conformations- One Subunit in An Inward-Facing and the Other in An Outward-Facing Conformation, PDB code: 6xpf:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Cryo-Em Structure of Human ZNT8 Wt, in the Absence of Zinc, Determined in Heterogeneous Conformations- One Subunit in An Inward-Facing and the Other in An Outward-Facing Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of Human ZNT8 Wt, in the Absence of Zinc, Determined in Heterogeneous Conformations- One Subunit in An Inward-Facing and the Other in An Outward-Facing Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:0.9 occ:1.00 CA A:CYS361 2.3 0.7 1.0 C A:CYS361 3.0 0.7 1.0 O A:CYS361 3.1 0.7 1.0 N A:CYS361 3.4 0.7 1.0 O A:ASP360 3.7 0.8 1.0 N A:CYS364 3.8 0.8 1.0 C A:ASP360 4.0 0.8 1.0 N A:LEU362 4.1 0.1 1.0 CA A:CYS364 4.3 0.8 1.0 N A:PHE363 4.4 0.6 1.0 O B:HIS52 4.5 0.9 1.0 O A:GLN357 4.6 0.7 1.0 C A:PHE363 4.6 0.6 1.0 C A:CYS364 4.8 0.8 1.0 CA A:PHE363 4.8 0.6 1.0

Zinc binding site 2 out of 4 in the Cryo-Em Structure of Human ZNT8 Wt, in the Absence of Zinc, Determined in Heterogeneous Conformations- One Subunit in An Inward-Facing and the Other in An Outward-Facing Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of Human ZNT8 Wt, in the Absence of Zinc, Determined in Heterogeneous Conformations- One Subunit in An Inward-Facing and the Other in An Outward-Facing Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn402 b:0.8 occ:1.00 O A:CYS53 2.9 0.7 1.0 CA A:CYS53 3.1 0.7 1.0 C A:CYS53 3.4 0.7 1.0 N A:CYS53 4.3 0.7 1.0 ZN B:ZN402 4.4 0.9 1.0 N A:HIS54 4.7 0.8 1.0 O A:HIS52 4.8 0.4 1.0 C A:HIS52 4.9 0.4 1.0

Zinc binding site 3 out of 4 in the Cryo-Em Structure of Human ZNT8 Wt, in the Absence of Zinc, Determined in Heterogeneous Conformations- One Subunit in An Inward-Facing and the Other in An Outward-Facing Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Cryo-Em Structure of Human ZNT8 Wt, in the Absence of Zinc, Determined in Heterogeneous Conformations- One Subunit in An Inward-Facing and the Other in An Outward-Facing Conformation within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn401 b:0.8 occ:1.00 O B:HIS52 3.9 0.9 1.0 C B:HIS52 4.5 0.9 1.0 O B:CYS53 4.9 0.1 1.0

Zinc binding site 4 out of 4 in the Cryo-Em Structure of Human ZNT8 Wt, in the Absence of Zinc, Determined in Heterogeneous Conformations- One Subunit in An Inward-Facing and the Other in An Outward-Facing Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Cryo-Em Structure of Human ZNT8 Wt, in the Absence of Zinc, Determined in Heterogeneous Conformations- One Subunit in An Inward-Facing and the Other in An Outward-Facing Conformation within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn402 b:0.9 occ:1.00 CA B:CYS361 3.1 0.7 1.0 O B:CYS361 3.1 0.7 1.0 C B:CYS361 3.5 0.7 1.0 N B:CYS364 4.2 0.2 1.0 ZN A:ZN402 4.4 0.8 1.0 N B:CYS361 4.4 0.7 1.0 O A:HIS52 4.6 0.4 1.0 CA B:CYS364 4.6 0.2 1.0 O B:CYS364 4.7 0.2 1.0 C B:CYS364 4.7 0.2 1.0 O A:CYS53 4.7 0.7 1.0 N B:LEU362 4.8 0.2 1.0

J.Xue, T.Xie, W.Zeng, Y.Jiang, X.C.Bai. Cryo-Em Structures of Human ZNT8 in Both Outward- and Inward-Facing Conformations. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 32723473
DOI: 10.7554/ELIFE.58823