Zinc in PDB 6xnz: Structure of RAG1 (R848M/E649V)-RAG2-Dna Target Capture Complex

All present enzymatic activity of Structure of RAG1 (R848M/E649V)-RAG2-Dna Target Capture Complex:
2.3.2.27;

The binding sites of Zinc atom in the Structure of RAG1 (R848M/E649V)-RAG2-Dna Target Capture Complex (pdb code 6xnz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of RAG1 (R848M/E649V)-RAG2-Dna Target Capture Complex, PDB code: 6xnz:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of RAG1 (R848M/E649V)-RAG2-Dna Target Capture Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of RAG1 (R848M/E649V)-RAG2-Dna Target Capture Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1101 b:45.6 occ:1.00 NE2 A:HIS942 2.0 37.0 1.0 NE2 A:HIS937 2.0 36.4 1.0 SG A:CYS730 2.2 37.4 1.0 SG A:CYS727 2.2 37.4 1.0 CB A:CYS730 2.4 37.4 1.0 CB A:CYS727 2.4 37.4 1.0 CE1 A:HIS937 2.7 36.4 1.0 N A:CYS730 2.7 37.4 1.0 CE1 A:HIS942 2.8 37.0 1.0 CA A:CYS730 3.0 37.4 1.0 CD2 A:HIS942 3.1 37.0 1.0 CD2 A:HIS937 3.2 36.4 1.0 O A:CYS730 3.6 37.4 1.0 C A:CYS730 3.7 37.4 1.0 C A:LEU729 3.8 36.9 1.0 ND1 A:HIS937 3.9 36.4 1.0 CA A:CYS727 3.9 37.4 1.0 ND1 A:HIS942 4.0 37.0 1.0 OG1 A:THR732 4.1 37.3 1.0 CG A:HIS942 4.2 37.0 1.0 CG A:HIS937 4.2 36.4 1.0 CB A:LEU729 4.3 36.9 1.0 N A:LEU729 4.4 36.9 1.0 CA A:LEU729 4.4 36.9 1.0 O A:SER745 4.5 37.0 1.0 C A:CYS727 4.5 37.4 1.0 N A:CYS727 4.7 37.4 1.0 O A:LEU729 4.7 36.9 1.0 ND1 A:HIS744 4.8 37.2 1.0 N A:ASP731 4.9 37.2 1.0 O A:CYS727 4.9 37.4 1.0

Zinc binding site 2 out of 2 in the Structure of RAG1 (R848M/E649V)-RAG2-Dna Target Capture Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of RAG1 (R848M/E649V)-RAG2-Dna Target Capture Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1101 b:56.8 occ:1.00 O C:LEU729 1.8 38.4 1.0 NE2 C:HIS942 2.0 37.6 1.0 NE2 C:HIS937 2.0 37.7 1.0 SG C:CYS730 2.1 39.9 1.0 SG C:CYS727 2.1 39.3 1.0 CB C:CYS727 2.7 39.3 1.0 CD2 C:HIS937 2.9 37.7 1.0 C C:LEU729 2.9 38.4 1.0 CE1 C:HIS942 2.9 37.6 1.0 CD2 C:HIS942 3.0 37.6 1.0 CE1 C:HIS937 3.1 37.7 1.0 CB C:CYS730 3.4 39.9 1.0 CA C:LEU729 3.7 38.4 1.0 CG2 C:THR732 3.7 39.3 1.0 N C:CYS730 3.8 39.9 1.0 CB C:LEU729 3.9 38.4 1.0 N C:LEU729 4.0 38.4 1.0 ND1 C:HIS942 4.0 37.6 1.0 CG C:HIS937 4.1 37.7 1.0 CA C:CYS730 4.1 39.9 1.0 CG C:HIS942 4.1 37.6 1.0 ND1 C:HIS937 4.1 37.7 1.0 CA C:CYS727 4.2 39.3 1.0 N C:ASP731 4.4 39.4 1.0 C C:CYS730 4.5 39.9 1.0 N C:THR732 4.6 39.3 1.0 CB C:THR732 4.6 39.3 1.0 CB C:HIS744 4.7 39.1 1.0 C C:CYS727 4.8 39.3 1.0 O C:ILE726 4.9 39.2 1.0

Y.Zhang, E.Corbett, S.Wu, D.G.Schatz. Structural Basis For the Activation and Suppression of Transposition During Evolution of the Rag Recombinase. Embo J. V. 39 05857 2020.
ISSN: ESSN 1460-2075
PubMed: 32945578
DOI: 10.15252/EMBJ.2020105857