Zinc in PDB 6ugw: Crystal Structure of the Fc Fragment of PF06438179/GP1111 An Infliximab Biosimilar in A C-Centered Orthorhombic Crystal Form, Lot A

The structure of Crystal Structure of the Fc Fragment of PF06438179/GP1111 An Infliximab Biosimilar in A C-Centered Orthorhombic Crystal Form, Lot A, PDB code: 6ugw was solved by S.J.Mayclin, T.E.Edwards, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.00
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	50.090, 148.090, 75.790, 90.00, 90.00, 90.00
R / Rfree (%)	18.1 / 21.9

The binding sites of Zinc atom in the Crystal Structure of the Fc Fragment of PF06438179/GP1111 An Infliximab Biosimilar in A C-Centered Orthorhombic Crystal Form, Lot A (pdb code 6ugw). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Crystal Structure of the Fc Fragment of PF06438179/GP1111 An Infliximab Biosimilar in A C-Centered Orthorhombic Crystal Form, Lot A, PDB code: 6ugw:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Crystal Structure of the Fc Fragment of PF06438179/GP1111 An Infliximab Biosimilar in A C-Centered Orthorhombic Crystal Form, Lot A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Fc Fragment of PF06438179/GP1111 An Infliximab Biosimilar in A C-Centered Orthorhombic Crystal Form, Lot A within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:24.9 occ:1.00 O A:HOH641 2.0 28.4 1.0 NE2 A:HIS313 2.0 23.1 1.0 O A:ACT504 2.0 32.1 1.0 NE2 A:HIS438 2.1 25.2 1.0 OXT A:ACT504 2.3 51.1 1.0 C A:ACT504 2.4 48.1 1.0 CE1 A:HIS313 3.0 24.1 1.0 CD2 A:HIS438 3.0 23.2 1.0 CD2 A:HIS313 3.0 26.1 1.0 CE1 A:HIS438 3.1 22.6 1.0 O A:HOH734 3.2 35.5 1.0 CH3 A:ACT504 3.7 48.6 1.0 CD1 A:LEU317 3.8 26.2 1.0 ND1 A:HIS313 4.1 20.8 1.0 CG A:HIS313 4.1 24.5 1.0 CG A:HIS438 4.2 22.7 1.0 ND1 A:HIS438 4.2 19.4 1.0 CD1 A:ILE256 4.8 50.5 1.0

Zinc binding site 2 out of 3 in the Crystal Structure of the Fc Fragment of PF06438179/GP1111 An Infliximab Biosimilar in A C-Centered Orthorhombic Crystal Form, Lot A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the Fc Fragment of PF06438179/GP1111 An Infliximab Biosimilar in A C-Centered Orthorhombic Crystal Form, Lot A within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn502 b:55.7 occ:1.00 O A:HOH649 2.1 54.7 1.0 O A:HOH736 2.2 44.5 1.0 CD2 A:HIS288 2.4 50.4 1.0 CG A:HIS288 3.2 49.9 1.0 CB A:HIS288 3.4 53.4 1.0 NE2 A:HIS288 3.6 52.5 1.0 CA A:HIS288 4.0 52.6 1.0 O A:HOH637 4.0 43.1 1.0 ND1 A:HIS288 4.4 49.6 1.0 OE2 A:GLU286 4.5 47.7 1.0 CE1 A:HIS288 4.6 51.3 1.0 O A:HIS288 4.7 51.8 1.0 O A:VAL287 4.7 53.0 1.0 C A:HIS288 4.8 53.1 1.0

Zinc binding site 3 out of 3 in the Crystal Structure of the Fc Fragment of PF06438179/GP1111 An Infliximab Biosimilar in A C-Centered Orthorhombic Crystal Form, Lot A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of the Fc Fragment of PF06438179/GP1111 An Infliximab Biosimilar in A C-Centered Orthorhombic Crystal Form, Lot A within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn503 b:66.7 occ:0.26 OE2 A:GLU321 2.1 90.1 1.0 O A:HOH692 2.4 54.2 1.0 OE1 A:GLU321 2.6 82.3 1.0 CD A:GLU321 2.6 74.5 1.0 CG A:GLU321 4.1 52.8 1.0 CG2 A:THR338 4.8 37.4 1.0 CB A:GLU321 4.8 37.4 1.0 O A:HOH739 4.8 44.5 1.0 O A:HOH604 4.9 51.0 1.0

T.F.Lerch, P.Sharpe, S.J.Mayclin, T.E.Edwards, S.Polleck, J.C.Rouse, Q.Zou, H.D.Conlon. Crystal Structures of Pf-06438179/GP1111, An Infliximab Biosimilar. Biodrugs 2019.
ISSN: ISSN 1179-190X
PubMed: 31650490
DOI: 10.1007/S40259-019-00390-1