Zinc in PDB 6t81: Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide.

Enzymatic activity of Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide.

All present enzymatic activity of Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide.:
4.2.1.1;

Protein crystallography data

The structure of Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide., PDB code: 6t81 was solved by A.Smirnov, E.Manakova, S.Grazulis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.64 / 0.98
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.032, 41.009, 71.684, 90.00, 104.13, 90.00
R / Rfree (%) 14.6 / 17.2

Other elements in 6t81:

The structure of Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide. also contains other interesting chemical elements:

Sodium (Na) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide. (pdb code 6t81). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide., PDB code: 6t81:

Zinc binding site 1 out of 1 in 6t81

Go back to Zinc Binding Sites List in 6t81
Zinc binding site 1 out of 1 in the Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:5.7
occ:1.00
N14 A:MUE302 1.8 5.9 0.3
NE2 A:HIS94 2.0 6.5 1.0
ND1 A:HIS119 2.0 5.3 1.0
N14 A:MUE302 2.0 6.2 0.7
NE2 A:HIS96 2.0 5.9 1.0
CE1 A:HIS119 2.9 5.8 1.0
O13 A:MUE302 2.9 6.1 0.3
S11 A:MUE302 3.0 5.5 0.3
CD2 A:HIS96 3.0 6.0 1.0
CD2 A:HIS94 3.0 6.3 1.0
CE1 A:HIS94 3.0 7.0 1.0
O13 A:MUE302 3.0 6.7 0.7
CE1 A:HIS96 3.1 6.9 1.0
S11 A:MUE302 3.1 6.1 0.7
CG A:HIS119 3.1 5.2 1.0
CB A:HIS119 3.6 5.6 1.0
O A:HOH582 3.7 10.9 1.0
OG1 A:THR199 3.8 6.1 1.0
OE1 A:GLU106 4.0 5.9 1.0
O12 A:MUE302 4.0 5.7 0.3
NE2 A:HIS119 4.1 5.7 1.0
O12 A:MUE302 4.1 6.3 0.7
C6 A:MUE302 4.1 7.7 0.3
ND1 A:HIS94 4.1 7.2 1.0
CG A:HIS94 4.2 6.7 1.0
ND1 A:HIS96 4.2 7.5 1.0
CG A:HIS96 4.2 6.0 1.0
CD2 A:HIS119 4.2 5.5 1.0
C6 A:MUE302 4.3 8.3 0.7
O A:HOH659 4.8 20.5 1.0
C5 A:MUE302 4.8 8.7 0.3
C7 A:MUE302 4.8 8.6 0.3
CD A:GLU106 4.9 5.8 1.0

Reference:

V.Dudutiene, A.Zubriene, V.Kairys, A.Smirnov, J.Smirnoviene, J.Leitans, A.Kazaks, K.Tars, L.Manakova, S.Grazulis, D.Matulis. Isoform-Selective Enzyme Inhibitors By Exploring Pocket Size According to the Lock-and-Key Principle. Biophys.J. V. 119 1513 2020.
ISSN: ESSN 1542-0086
PubMed: 32971003
DOI: 10.1016/J.BPJ.2020.08.037
Page generated: Wed Dec 16 12:52:02 2020

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