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Zinc in PDB 8oo8: Three-Dimensional Structure of Human Carbonic Anhydrase II in Complex with A Covalent Inhibitor

Enzymatic activity of Three-Dimensional Structure of Human Carbonic Anhydrase II in Complex with A Covalent Inhibitor

All present enzymatic activity of Three-Dimensional Structure of Human Carbonic Anhydrase II in Complex with A Covalent Inhibitor:
4.2.1.1;

Protein crystallography data

The structure of Three-Dimensional Structure of Human Carbonic Anhydrase II in Complex with A Covalent Inhibitor, PDB code: 8oo8 was solved by J.Leitans, K.Tars, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 70.50 / 1.40
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.45, 41.57, 72.79, 90, 104.4, 90
R / Rfree (%) 18.5 / 21.5

Other elements in 8oo8:

The structure of Three-Dimensional Structure of Human Carbonic Anhydrase II in Complex with A Covalent Inhibitor also contains other interesting chemical elements:

Fluorine (F) 3 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Three-Dimensional Structure of Human Carbonic Anhydrase II in Complex with A Covalent Inhibitor (pdb code 8oo8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Three-Dimensional Structure of Human Carbonic Anhydrase II in Complex with A Covalent Inhibitor, PDB code: 8oo8:

Zinc binding site 1 out of 1 in 8oo8

Go back to Zinc Binding Sites List in 8oo8
Zinc binding site 1 out of 1 in the Three-Dimensional Structure of Human Carbonic Anhydrase II in Complex with A Covalent Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Three-Dimensional Structure of Human Carbonic Anhydrase II in Complex with A Covalent Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:15.9
occ:1.00
N4 A:VV8302 2.0 10.2 1.0
ND1 A:HIS119 2.0 6.9 1.0
NE2 A:HIS94 2.0 7.0 1.0
NE2 A:HIS96 2.1 7.2 1.0
F13 A:VV8302 2.4 14.3 1.0
CE1 A:HIS119 2.9 6.6 1.0
C12 A:VV8302 2.9 14.0 1.0
CE1 A:HIS94 3.0 7.4 1.0
S1 A:VV8302 3.0 10.2 1.0
CD2 A:HIS96 3.1 7.1 1.0
CD2 A:HIS94 3.1 6.8 1.0
CE1 A:HIS96 3.1 8.2 1.0
CG A:HIS119 3.1 5.9 1.0
C7 A:VV8302 3.3 13.0 1.0
O2 A:VV8302 3.4 10.8 1.0
CB A:HIS119 3.6 5.5 1.0
OE1 A:GLU106 3.8 7.0 1.0
OG1 A:THR199 3.9 5.3 1.0
C11 A:VV8302 4.0 17.3 1.0
NE2 A:HIS119 4.1 5.9 1.0
ND1 A:HIS94 4.1 6.1 1.0
CG A:HIS96 4.2 6.4 1.0
CD2 A:HIS119 4.2 5.8 1.0
CG A:HIS94 4.2 6.2 1.0
ND1 A:HIS96 4.2 6.3 1.0
O3 A:VV8302 4.3 10.3 1.0
F15 A:VV8302 4.4 18.0 1.0
C8 A:VV8302 4.5 15.7 1.0
CD A:GLU106 4.8 5.8 1.0

Reference:

J.Leitans, K.Tars. Three-Dimensional Structure of Human Carbonic Anhydrase II in Complex with A Covalent Inhibitor To Be Published.
Page generated: Thu Oct 31 08:52:32 2024

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