Zinc in PDB 8jyi: Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid E

All present enzymatic activity of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid E:
3.1.26.4;

The structure of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid E, PDB code: 8jyi was solved by Y.Ito, H.Lu, M.Kitajima, H.Ishikawa, Y.Nakata, Y.Iwatani, T.Hoshino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.62 / 1.92
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	61.693, 61.693, 83.234, 90, 90, 90
R / Rfree (%)	21.7 / 25.3

The structure of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid E also contains other interesting chemical elements:

Manganese

(Mn)

2 atoms

The binding sites of Zinc atom in the Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid E (pdb code 8jyi). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid E, PDB code: 8jyi:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid E


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid E within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn204 b:45.4 occ:1.00 NE2 A:HIS129 2.3 50.0 1.0 OE2 A:GLU136 2.3 49.6 1.0 OE1 A:GLU136 2.8 53.0 1.0 CD A:GLU136 2.8 56.1 1.0 CD2 A:HIS129 3.0 50.3 1.0 CE1 A:HIS129 3.4 48.7 1.0 CA A:GLY133 3.9 55.3 1.0 C A:GLY133 4.1 52.3 1.0 N A:GLY134 4.2 46.9 1.0 CG A:GLU136 4.2 57.8 1.0 N A:ASN135 4.2 45.9 1.0 CG A:HIS129 4.3 51.8 1.0 N A:GLY133 4.3 59.2 1.0 O A:HOH315 4.3 46.7 1.0 CB A:ASN135 4.4 43.8 1.0 ND1 A:HIS129 4.4 48.6 1.0 N A:GLU136 4.6 47.0 1.0 CA A:ASN135 4.8 45.8 1.0 O A:GLY133 4.8 51.5 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid E


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid E within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn205 b:47.9 occ:1.00 OE2 A:GLU72 1.9 41.3 1.0 OE1 A:GLU119 2.0 48.0 1.0 O A:HOH321 2.2 39.9 1.0 CD A:GLU119 2.7 49.5 1.0 OE2 A:GLU119 2.8 52.9 1.0 CD A:GLU72 2.9 42.5 1.0 CG A:GLU72 3.2 42.9 1.0 OE1 A:GLU72 4.0 41.1 1.0 CG A:GLU119 4.1 47.7 1.0 CB A:GLU119 4.7 45.4 1.0 CB A:GLU72 4.8 41.5 1.0

Y.Ito, H.Lu, M.Kitajima, H.Ishikawa, Y.Nakata, Y.Iwatani, T.Hoshino. Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid E To Be Published.