Zinc in PDB 8je1: An Asymmetry Dimer of the CUL2-RBX1-Elobc-FEM1B Ubiquitin Ligase Complexed with BEX2

All present enzymatic activity of An Asymmetry Dimer of the CUL2-RBX1-Elobc-FEM1B Ubiquitin Ligase Complexed with BEX2:
2.3.2.27; 2.3.2.32;

The binding sites of Zinc atom in the An Asymmetry Dimer of the CUL2-RBX1-Elobc-FEM1B Ubiquitin Ligase Complexed with BEX2 (pdb code 8je1). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the An Asymmetry Dimer of the CUL2-RBX1-Elobc-FEM1B Ubiquitin Ligase Complexed with BEX2, PDB code: 8je1:

Zinc binding site 1 out of 1 in the An Asymmetry Dimer of the CUL2-RBX1-Elobc-FEM1B Ubiquitin Ligase Complexed with BEX2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of An Asymmetry Dimer of the CUL2-RBX1-Elobc-FEM1B Ubiquitin Ligase Complexed with BEX2 within 5.0Å range: probe atom residue distance (Å) B Occ I:Zn701 b:214.0 occ:1.00 OD1 I:ASP567 2.2 147.1 1.0 NE2 I:HIS627 2.3 155.5 1.0 SG I:CYS599 2.3 147.0 1.0 OD2 I:ASP567 2.4 147.1 1.0 CE1 I:HIS627 2.6 155.5 1.0 CG I:ASP567 2.6 147.1 1.0 CD2 I:HIS565 3.2 138.9 1.0 CD2 I:HIS627 3.6 155.5 1.0 CB I:CYS599 3.8 147.0 1.0 ND1 I:HIS627 3.9 155.5 1.0 CE1 I:PHE623 3.9 153.5 1.0 NE2 I:HIS565 4.0 138.9 1.0 CB I:ASP567 4.1 147.1 1.0 CZ I:PHE623 4.2 153.5 1.0 CG I:HIS565 4.3 138.9 1.0 CG I:HIS627 4.4 155.5 1.0 CB I:HIS565 4.8 138.9 1.0 N I:ASP567 4.9 147.1 1.0 CA I:CYS599 5.0 166.4 1.0 CA I:ASP567 5.0 147.1 1.0

Z.Dai, L.Liang, W.Wang, P.Zuo, S.Yu, Y.Liu, X.Zhao, Y.Lu, Y.Jin, F.Zhang, D.Ding, W.Deng, Y.Yin. Structural Insights Into the Ubiquitylation Strategy of the Oligomeric CRL2 FEM1B E3 Ubiquitin Ligase. Embo J. 2024.
ISSN: ESSN 1460-2075
PubMed: 38360992
DOI: 10.1038/S44318-024-00047-Y