Zinc in PDB 8hkk: Ion Channel

The structure of Ion Channel also contains other interesting chemical elements:

Potassium	(K)	18 atoms
Sodium	(Na)	1 atom

The binding sites of Zinc atom in the Ion Channel (pdb code 8hkk). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Ion Channel, PDB code: 8hkk:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Ion Channel


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Ion Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1301 b:168.7 occ:1.00 ND1 A:HIS787 2.1 114.6 1.0 SG A:CYS785 2.3 116.8 1.0 SG A:CYS777 2.3 77.5 1.0 SG A:CYS778 2.3 86.1 1.0 CE1 A:HIS787 2.8 112.5 1.0 CG A:HIS787 3.1 114.0 1.0 CB A:CYS785 3.1 110.9 1.0 N A:CYS778 3.5 69.3 1.0 CB A:CYS778 3.6 74.4 1.0 CB A:CYS777 3.6 76.9 1.0 CB A:HIS787 3.6 113.0 1.0 CA A:CYS778 3.7 71.3 1.0 C A:CYS777 3.8 73.9 1.0 NE2 A:HIS787 3.9 111.7 1.0 N A:HIS787 3.9 111.7 1.0 CD2 A:HIS787 4.1 112.4 1.0 CA A:CYS777 4.3 73.1 1.0 O A:CYS777 4.3 80.0 1.0 CG A:PRO775 4.3 68.0 1.0 CA A:HIS787 4.4 112.0 1.0 N A:LYS786 4.4 114.8 1.0 CA A:CYS785 4.5 109.8 1.0 C A:CYS785 4.7 110.7 1.0 N A:ASN788 4.9 117.9 1.0 CB A:PRO775 4.9 68.7 1.0 N A:CYS777 5.0 75.0 1.0

Zinc binding site 2 out of 4 in the Ion Channel


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Ion Channel within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1301 b:172.6 occ:1.00 ND1 B:HIS787 2.1 114.0 1.0 SG B:CYS777 2.3 79.3 1.0 SG B:CYS785 2.3 113.0 1.0 SG B:CYS778 2.3 90.8 1.0 CE1 B:HIS787 2.8 111.5 1.0 CB B:CYS785 3.1 108.9 1.0 CG B:HIS787 3.1 112.4 1.0 N B:CYS778 3.4 73.5 1.0 CB B:CYS778 3.6 80.0 1.0 CB B:HIS787 3.6 112.3 1.0 CB B:CYS777 3.6 82.0 1.0 CA B:CYS778 3.7 77.7 1.0 C B:CYS777 3.8 77.9 1.0 N B:HIS787 3.9 111.0 1.0 NE2 B:HIS787 3.9 109.6 1.0 CD2 B:HIS787 4.1 110.0 1.0 O B:CYS777 4.3 82.8 1.0 CA B:CYS777 4.3 78.4 1.0 CA B:HIS787 4.3 111.4 1.0 N B:LYS786 4.4 112.8 1.0 CG B:PRO775 4.4 71.7 1.0 CA B:CYS785 4.4 109.2 1.0 ND2 B:ASN788 4.6 114.5 1.0 C B:CYS785 4.7 108.9 1.0 N B:ASN788 4.8 117.0 1.0 N B:CYS777 5.0 78.7 1.0 C B:LYS786 5.0 112.4 1.0 CB B:PRO775 5.0 69.6 1.0

Zinc binding site 3 out of 4 in the Ion Channel


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Ion Channel within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1301 b:169.7 occ:1.00 ND1 C:HIS787 2.1 117.1 1.0 SG C:CYS777 2.3 77.0 1.0 SG C:CYS785 2.3 117.8 1.0 SG C:CYS778 2.3 84.0 1.0 CE1 C:HIS787 2.8 114.8 1.0 CB C:CYS785 3.1 112.3 1.0 CG C:HIS787 3.1 115.7 1.0 N C:CYS778 3.5 67.3 1.0 CB C:CYS778 3.6 72.2 1.0 CB C:HIS787 3.6 114.7 1.0 CB C:CYS777 3.7 77.2 1.0 CA C:CYS778 3.7 69.9 1.0 C C:CYS777 3.8 72.2 1.0 N C:HIS787 3.9 114.2 1.0 NE2 C:HIS787 3.9 113.3 1.0 CD2 C:HIS787 4.1 113.9 1.0 CA C:CYS777 4.4 72.9 1.0 CA C:HIS787 4.4 113.6 1.0 O C:CYS777 4.4 78.3 1.0 N C:LYS786 4.4 116.5 1.0 CG C:PRO775 4.4 63.3 1.0 CA C:CYS785 4.4 111.0 1.0 ND2 C:ASN788 4.6 113.7 1.0 C C:CYS785 4.7 111.2 1.0 N C:ASN788 4.8 116.3 1.0 CB C:PRO775 5.0 64.5 1.0

Zinc binding site 4 out of 4 in the Ion Channel


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Ion Channel within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1301 b:165.4 occ:1.00 ND1 D:HIS787 2.1 105.5 1.0 SG D:CYS785 2.3 105.8 1.0 SG D:CYS777 2.3 74.2 1.0 SG D:CYS778 2.3 84.1 1.0 CE1 D:HIS787 2.8 103.6 1.0 CG D:HIS787 3.1 104.1 1.0 CB D:CYS785 3.2 101.8 1.0 N D:CYS778 3.4 65.9 1.0 CB D:CYS777 3.6 76.3 1.0 CB D:CYS778 3.6 73.6 1.0 CB D:HIS787 3.6 104.0 1.0 CA D:CYS778 3.7 70.6 1.0 C D:CYS777 3.8 72.2 1.0 N D:HIS787 3.9 102.3 1.0 NE2 D:HIS787 3.9 101.7 1.0 CD2 D:HIS787 4.1 102.4 1.0 CA D:CYS777 4.3 72.1 1.0 O D:CYS777 4.3 78.1 1.0 CA D:HIS787 4.4 103.4 1.0 CG D:PRO775 4.4 66.9 1.0 N D:LYS786 4.4 102.9 1.0 CA D:CYS785 4.5 102.0 1.0 C D:CYS785 4.7 101.7 1.0 N D:ASN788 4.9 111.5 1.0 N D:CYS777 4.9 73.9 1.0 CB D:PRO775 4.9 65.8 1.0

J.Zhang, S.Liu, J.Fan, R.Yan, B.Huang, F.Zhou, T.Yuan, J.Gong, Z.Huang, D.Jiang. Structural Basis of Human SLO2.2 Channel Gating and Modulation. Cell Rep V. 42 12858 2023.
ISSN: ESSN 2211-1247
PubMed: 37494189
DOI: 10.1016/J.CELREP.2023.112858