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Zinc in PDB 7yix: The Cryo-Em Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (Scfv) Complex.

Enzymatic activity of The Cryo-Em Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (Scfv) Complex.

All present enzymatic activity of The Cryo-Em Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (Scfv) Complex.:
3.1.3.1; 3.9.1.1;

Other elements in 7yix:

The structure of The Cryo-Em Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (Scfv) Complex. also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms
Calcium (Ca) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the The Cryo-Em Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (Scfv) Complex. (pdb code 7yix). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the The Cryo-Em Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (Scfv) Complex., PDB code: 7yix:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 7yix

Go back to Zinc Binding Sites List in 7yix
Zinc binding site 1 out of 4 in the The Cryo-Em Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (Scfv) Complex.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Cryo-Em Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (Scfv) Complex. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn604

b:62.9
occ:1.00
NE2 A:HIS454 2.3 53.3 1.0
NE2 A:HIS341 2.3 49.9 1.0
OD1 A:ASP337 2.4 53.1 1.0
OD2 A:ASP337 2.4 53.1 1.0
CG A:ASP337 2.6 53.1 1.0
CD2 A:HIS341 3.1 49.9 1.0
CE1 A:HIS454 3.1 53.3 1.0
CE1 A:HIS341 3.4 49.9 1.0
CD2 A:HIS454 3.4 53.3 1.0
NE2 A:HIS379 3.9 53.9 1.0
CE1 A:HIS379 4.0 53.9 1.0
CB A:ASP337 4.0 53.1 1.0
OG A:SER110 4.2 55.9 1.0
ND1 A:HIS454 4.3 53.3 1.0
CG A:HIS341 4.3 49.9 1.0
ND1 A:HIS341 4.4 49.9 1.0
CE1 A:HIS381 4.4 49.9 1.0
ZN A:ZN606 4.4 74.6 1.0
CG A:HIS454 4.4 53.3 1.0
NE2 A:HIS381 4.6 49.9 1.0
CA A:ASP337 4.9 53.1 1.0
O A:ASP337 5.0 53.1 1.0

Zinc binding site 2 out of 4 in 7yix

Go back to Zinc Binding Sites List in 7yix
Zinc binding site 2 out of 4 in the The Cryo-Em Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (Scfv) Complex.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of The Cryo-Em Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (Scfv) Complex. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn606

b:74.6
occ:1.00
OD2 A:ASP378 2.1 54.9 1.0
NE2 A:HIS379 2.3 53.9 1.0
CG A:ASP378 2.7 54.9 1.0
OD1 A:ASP378 2.7 54.9 1.0
CE1 A:HIS379 2.7 53.9 1.0
OD2 A:ASP337 3.0 53.1 1.0
CD2 A:HIS379 3.0 53.9 1.0
OG A:SER110 3.1 55.9 1.0
ND1 A:HIS379 3.5 53.9 1.0
CG A:HIS379 3.7 53.9 1.0
CB A:ASP378 4.1 54.9 1.0
CG A:ASP337 4.1 53.1 1.0
CB A:SER110 4.2 55.9 1.0
N A:GLY61 4.2 52.0 1.0
CG A:ASP60 4.2 56.0 1.0
OD2 A:ASP60 4.3 56.0 1.0
CB A:ASP60 4.3 56.0 1.0
CA A:SER110 4.3 55.9 1.0
ZN A:ZN604 4.4 62.9 1.0
CA A:ASP60 4.5 56.0 1.0
C A:ASP60 4.7 56.0 1.0
N A:HIS379 4.7 53.9 1.0
OD1 A:ASP60 4.7 56.0 1.0
CE1 A:HIS454 4.8 53.3 1.0
O A:ASP109 4.8 58.7 1.0
N A:SER110 4.9 55.9 1.0
OD1 A:ASP337 4.9 53.1 1.0
NE2 A:HIS454 4.9 53.3 1.0
CB A:ASP337 4.9 53.1 1.0
CA A:GLY61 4.9 52.0 1.0
C A:ASP378 5.0 54.9 1.0
CB A:HIS379 5.0 53.9 1.0

Zinc binding site 3 out of 4 in 7yix

Go back to Zinc Binding Sites List in 7yix
Zinc binding site 3 out of 4 in the The Cryo-Em Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (Scfv) Complex.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of The Cryo-Em Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (Scfv) Complex. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn604

b:67.5
occ:1.00
OD2 B:ASP337 2.0 52.4 1.0
NE2 B:HIS341 2.3 50.8 1.0
NE2 B:HIS454 2.3 54.0 1.0
CG B:ASP337 2.8 52.4 1.0
CE1 B:HIS454 2.8 54.0 1.0
OD1 B:ASP337 2.9 52.4 1.0
CD2 B:HIS341 3.2 50.8 1.0
CE1 B:HIS341 3.3 50.8 1.0
CD2 B:HIS454 3.5 54.0 1.0
NE2 B:HIS379 3.8 55.9 1.0
ND1 B:HIS454 4.0 54.0 1.0
OG B:SER110 4.2 56.7 1.0
CE1 B:HIS379 4.2 55.9 1.0
CB B:ASP337 4.2 52.4 1.0
CG B:HIS454 4.4 54.0 1.0
CG B:HIS341 4.4 50.8 1.0
ND1 B:HIS341 4.4 50.8 1.0
CE1 B:HIS381 4.5 50.8 1.0
ZN B:ZN606 4.6 76.6 1.0
NE2 B:HIS381 4.6 50.8 1.0
CD2 B:HIS379 4.9 55.9 1.0

Zinc binding site 4 out of 4 in 7yix

Go back to Zinc Binding Sites List in 7yix
Zinc binding site 4 out of 4 in the The Cryo-Em Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (Scfv) Complex.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of The Cryo-Em Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (Scfv) Complex. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn606

b:76.6
occ:1.00
CE1 B:HIS379 1.4 55.9 1.0
OD1 B:ASP60 2.1 55.8 1.0
OD2 B:ASP378 2.2 55.5 1.0
ND1 B:HIS379 2.3 55.9 1.0
NE2 B:HIS379 2.5 55.9 1.0
CG B:ASP378 3.0 55.5 1.0
OD1 B:ASP378 3.1 55.5 1.0
OG B:SER110 3.3 56.7 1.0
CG B:ASP60 3.3 55.8 1.0
CG B:HIS379 3.5 55.9 1.0
CD2 B:HIS379 3.5 55.9 1.0
OD2 B:ASP60 3.9 55.8 1.0
CB B:SER110 4.1 56.7 1.0
N B:GLY61 4.1 52.7 1.0
CA B:SER110 4.3 56.7 1.0
CE1 B:HIS454 4.3 54.0 1.0
OD2 B:ASP337 4.3 52.4 1.0
CB B:ASP378 4.3 55.5 1.0
CG B:ASP337 4.3 52.4 1.0
OD1 B:ASP337 4.4 52.4 1.0
CB B:ASP60 4.4 55.8 1.0
CA B:ASP60 4.5 55.8 1.0
ZN B:ZN604 4.6 67.5 1.0
C B:ASP60 4.6 55.8 1.0
CB B:HIS379 4.8 55.9 1.0
N B:SER110 4.8 56.7 1.0
CA B:GLY61 4.8 52.7 1.0
O B:ASP109 4.9 58.9 1.0
N B:HIS379 4.9 55.9 1.0
CB B:ASP337 4.9 52.4 1.0
ND1 B:HIS454 4.9 54.0 1.0

Reference:

Y.Yu, K.Rong, D.Yao, Q.Zhang, X.Cao, B.Rao, Y.Xia, Y.Lu, Y.Shen, Y.Yao, H.Xu, P.Ma, Y.Cao, A.Qin. The Structural Pathology For Hypophosphatasia Caused By Malfunctional Tissue Non-Specific Alkaline Phosphatase. Nat Commun V. 14 4048 2023.
ISSN: ESSN 2041-1723
PubMed: 37422472
DOI: 10.1038/S41467-023-39833-3
Page generated: Wed Oct 30 15:54:19 2024

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