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Zinc in PDB 7wdb: Human TRPC5 Channel in Complex with Riluzole

Other elements in 7wdb:

The structure of Human TRPC5 Channel in Complex with Riluzole also contains other interesting chemical elements:

Calcium (Ca) 4 atoms
Fluorine (F) 12 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Human TRPC5 Channel in Complex with Riluzole (pdb code 7wdb). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Human TRPC5 Channel in Complex with Riluzole, PDB code: 7wdb:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 7wdb

Go back to Zinc Binding Sites List in 7wdb
Zinc binding site 1 out of 4 in the Human TRPC5 Channel in Complex with Riluzole


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human TRPC5 Channel in Complex with Riluzole within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn903

b:166.3
occ:1.00
 ND1 A:HIS172 2.1 113.4 1.0
SG A:CYS181 2.3 136.4 1.0
SG A:CYS178 2.3 134.6 1.0
SG A:CYS176 2.3 112.7 1.0
CE1 A:HIS172 3.1 108.9 1.0
CG A:HIS172 3.1 101.5 1.0
CB A:HIS172 3.4 96.6 1.0
CB A:CYS181 3.4 125.0 1.0
CB A:CYS178 3.4 124.5 1.0
CB A:CYS176 3.6 108.9 1.0
N A:CYS178 4.1 116.7 1.0
NE2 A:HIS172 4.1 102.0 1.0
CD2 A:HIS172 4.2 97.7 1.0
N A:CYS181 4.2 123.2 1.0
CA A:CYS178 4.3 120.2 1.0
CA A:CYS181 4.4 121.5 1.0
CA A:CYS176 4.8 110.7 1.0
C A:CYS178 4.8 122.2 1.0
C A:CYS176 4.9 115.5 1.0
CA A:HIS172 4.9 88.2 1.0
O A:CYS178 4.9 122.1 1.0
N A:ASN177 5.0 115.3 1.0

Zinc binding site 2 out of 4 in 7wdb

Go back to Zinc Binding Sites List in 7wdb
Zinc binding site 2 out of 4 in the Human TRPC5 Channel in Complex with Riluzole


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human TRPC5 Channel in Complex with Riluzole within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn903

b:166.3
occ:1.00
 ND1 B:HIS172 2.1 113.4 1.0
SG B:CYS178 2.3 134.6 1.0
SG B:CYS181 2.3 136.4 1.0
SG B:CYS176 2.3 112.7 1.0
CE1 B:HIS172 3.1 108.9 1.0
CG B:HIS172 3.1 101.5 1.0
CB B:HIS172 3.4 96.6 1.0
CB B:CYS181 3.4 125.0 1.0
CB B:CYS178 3.4 124.5 1.0
CB B:CYS176 3.6 108.9 1.0
N B:CYS178 4.1 116.7 1.0
NE2 B:HIS172 4.1 102.0 1.0
CD2 B:HIS172 4.2 97.7 1.0
N B:CYS181 4.2 123.2 1.0
CA B:CYS178 4.3 120.2 1.0
CA B:CYS181 4.4 121.5 1.0
CA B:CYS176 4.8 110.7 1.0
C B:CYS178 4.8 122.2 1.0
C B:CYS176 4.9 115.5 1.0
CA B:HIS172 4.9 88.2 1.0
O B:CYS178 4.9 122.1 1.0
N B:ASN177 5.0 115.3 1.0

Zinc binding site 3 out of 4 in 7wdb

Go back to Zinc Binding Sites List in 7wdb
Zinc binding site 3 out of 4 in the Human TRPC5 Channel in Complex with Riluzole


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Human TRPC5 Channel in Complex with Riluzole within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn903

b:166.3
occ:1.00
 ND1 C:HIS172 2.1 113.4 1.0
SG C:CYS181 2.3 136.4 1.0
SG C:CYS176 2.3 112.7 1.0
SG C:CYS178 2.3 134.6 1.0
CE1 C:HIS172 3.1 108.9 1.0
CG C:HIS172 3.1 101.5 1.0
CB C:HIS172 3.4 96.6 1.0
CB C:CYS181 3.4 125.0 1.0
CB C:CYS178 3.4 124.5 1.0
CB C:CYS176 3.6 108.9 1.0
N C:CYS178 4.1 116.7 1.0
NE2 C:HIS172 4.1 102.0 1.0
CD2 C:HIS172 4.2 97.7 1.0
N C:CYS181 4.2 123.2 1.0
CA C:CYS178 4.3 120.2 1.0
CA C:CYS181 4.4 121.5 1.0
CA C:CYS176 4.8 110.7 1.0
C C:CYS178 4.8 122.2 1.0
C C:CYS176 4.9 115.5 1.0
CA C:HIS172 4.9 88.2 1.0
O C:CYS178 4.9 122.1 1.0
N C:ASN177 5.0 115.3 1.0

Zinc binding site 4 out of 4 in 7wdb

Go back to Zinc Binding Sites List in 7wdb
Zinc binding site 4 out of 4 in the Human TRPC5 Channel in Complex with Riluzole


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Human TRPC5 Channel in Complex with Riluzole within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn903

b:166.3
occ:1.00
 ND1 D:HIS172 2.1 113.4 1.0
SG D:CYS181 2.3 136.4 1.0
SG D:CYS178 2.3 134.6 1.0
SG D:CYS176 2.3 112.7 1.0
CE1 D:HIS172 3.1 108.9 1.0
CG D:HIS172 3.1 101.5 1.0
CB D:HIS172 3.4 96.6 1.0
CB D:CYS181 3.4 125.0 1.0
CB D:CYS178 3.4 124.5 1.0
CB D:CYS176 3.6 108.9 1.0
N D:CYS178 4.1 116.7 1.0
NE2 D:HIS172 4.1 102.0 1.0
CD2 D:HIS172 4.2 97.7 1.0
N D:CYS181 4.2 123.2 1.0
CA D:CYS178 4.3 120.2 1.0
CA D:CYS181 4.4 121.5 1.0
CA D:CYS176 4.8 110.7 1.0
C D:CYS178 4.8 122.2 1.0
C D:CYS176 4.9 115.5 1.0
CA D:HIS172 4.9 88.2 1.0
O D:CYS178 4.9 122.1 1.0
N D:ASN177 5.0 115.3 1.0

Reference:

Y.Yang, M.Wei, L.Chen. Structural Identification of Riluzole-Binding Site on Human TRPC5. Cell Discov V. 8 67 2022.
ISSN: ESSN 2056-5968
PubMed: 35821012
DOI: 10.1038/S41421-022-00410-5
Page generated: Wed Oct 30 14:21:20 2024

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