Zinc in PDB 7v0w: Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2,5 )Pa

All present enzymatic activity of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2,5 )Pa:
2.7.7.86;

The structure of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2,5 )Pa, PDB code: 7v0w was solved by S.Wu, S.B.Gabelli, J.Sohn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.91 / 2.66
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	78.475, 99.474, 142.088, 90, 90, 90
R / Rfree (%)	19.9 / 23.8

The structure of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2,5 )Pa also contains other interesting chemical elements:

Manganese

(Mn)

2 atoms

The binding sites of Zinc atom in the Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2,5 )Pa (pdb code 7v0w). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2,5 )Pa, PDB code: 7v0w:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2,5 )Pa


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2,5 )Pa within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn601 b:50.2 occ:1.00 NE2 A:HIS378 1.9 53.2 1.0 SG A:CYS385 2.3 52.3 1.0 SG A:CYS384 2.3 52.4 1.0 SG A:CYS392 2.4 52.8 1.0 CD2 A:HIS378 2.9 52.9 1.0 CE1 A:HIS378 3.0 53.0 1.0 CB A:CYS385 3.3 51.9 1.0 CB A:CYS392 3.4 53.7 1.0 CB A:CYS384 3.5 50.8 1.0 N A:CYS385 3.7 50.5 1.0 N A:CYS392 3.8 54.3 1.0 C A:CYS384 3.8 49.8 1.0 CG A:HIS378 4.0 52.2 1.0 ND1 A:HIS378 4.0 52.2 1.0 CA A:CYS385 4.1 50.8 1.0 CA A:CYS392 4.1 54.7 1.0 CA A:CYS384 4.2 50.3 1.0 O A:CYS384 4.2 48.6 1.0 NH1 A:ARG394 4.4 49.8 1.0 C A:CYS392 4.7 54.9 1.0 O A:CYS392 4.8 54.7 1.0 O A:ALA390 4.8 56.6 1.0 C A:LYS391 4.8 56.2 1.0

Zinc binding site 2 out of 2 in the Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2,5 )Pa


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2,5 )Pa within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn601 b:51.8 occ:1.00 NE2 C:HIS378 2.0 52.5 1.0 SG C:CYS385 2.3 54.2 1.0 SG C:CYS392 2.3 53.8 1.0 SG C:CYS384 2.3 52.7 1.0 CD2 C:HIS378 2.9 50.9 1.0 CE1 C:HIS378 3.0 51.1 1.0 CB C:CYS385 3.3 54.7 1.0 CB C:CYS392 3.3 54.7 1.0 CB C:CYS384 3.5 52.1 1.0 N C:CYS385 3.7 53.9 1.0 N C:CYS392 3.8 56.9 1.0 C C:CYS384 3.8 52.1 1.0 CG C:HIS378 4.1 48.9 1.0 CA C:CYS385 4.1 55.1 1.0 CA C:CYS392 4.1 55.8 1.0 ND1 C:HIS378 4.1 48.9 1.0 CA C:CYS384 4.1 51.6 1.0 O C:CYS384 4.2 51.4 1.0 NH1 C:ARG394 4.4 52.7 1.0 C C:CYS392 4.6 55.1 1.0 O C:ALA390 4.8 59.7 1.0 O C:CYS392 4.8 56.1 1.0 C C:LYS391 4.8 59.2 1.0

S.Wu, S.B.Gabelli, J.S.Sohn. Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pa To Be Published.