Zinc in PDB 7v0r: Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Ppcpg(2 , 5 )Pa

All present enzymatic activity of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Ppcpg(2 , 5 )Pa:
2.7.7.86;

The structure of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Ppcpg(2 , 5 )Pa, PDB code: 7v0r was solved by S.Wu, S.B.Gabelli, J.Sohn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.61 / 2.51
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	78.112, 98.446, 142.598, 90, 90, 90
R / Rfree (%)	21.1 / 25

The structure of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Ppcpg(2 , 5 )Pa also contains other interesting chemical elements:

Magnesium

(Mg)

4 atoms

The binding sites of Zinc atom in the Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Ppcpg(2 , 5 )Pa (pdb code 7v0r). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Ppcpg(2 , 5 )Pa, PDB code: 7v0r:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Ppcpg(2 , 5 )Pa


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Ppcpg(2 , 5 )Pa within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn604 b:38.3 occ:1.00 NE2 A:HIS378 2.0 40.0 1.0 SG A:CYS385 2.3 39.7 1.0 SG A:CYS392 2.3 39.1 1.0 SG A:CYS384 2.3 38.1 1.0 CD2 A:HIS378 2.9 39.7 1.0 CE1 A:HIS378 3.0 40.1 1.0 CB A:CYS392 3.3 40.8 1.0 CB A:CYS385 3.3 38.6 1.0 CB A:CYS384 3.5 36.9 1.0 C A:CYS384 3.8 37.4 1.0 N A:CYS385 3.8 38.3 1.0 N A:CYS392 3.8 42.1 1.0 CA A:CYS392 4.1 41.9 1.0 CG A:HIS378 4.1 39.2 1.0 ND1 A:HIS378 4.1 39.8 1.0 CA A:CYS385 4.1 38.2 1.0 CA A:CYS384 4.2 36.8 1.0 O A:CYS384 4.2 36.8 1.0 NH1 A:ARG394 4.4 40.3 1.0 C A:CYS392 4.6 42.5 1.0 O A:CYS392 4.7 44.1 1.0 C A:LYS391 4.8 44.1 1.0 O A:ALA390 4.9 41.7 1.0

Zinc binding site 2 out of 2 in the Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Ppcpg(2 , 5 )Pa


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Ppcpg(2 , 5 )Pa within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn604 b:37.8 occ:1.00 NE2 C:HIS378 2.0 38.0 1.0 SG C:CYS385 2.3 39.7 1.0 SG C:CYS392 2.3 40.8 1.0 SG C:CYS384 2.3 38.9 1.0 CD2 C:HIS378 3.0 35.9 1.0 CE1 C:HIS378 3.0 37.3 1.0 CB C:CYS392 3.3 42.7 1.0 CB C:CYS385 3.3 39.8 1.0 CB C:CYS384 3.5 38.5 1.0 N C:CYS385 3.8 39.0 1.0 C C:CYS384 3.8 37.8 1.0 N C:CYS392 3.8 44.0 1.0 CA C:CYS392 4.1 43.4 1.0 ND1 C:HIS378 4.1 35.4 1.0 CG C:HIS378 4.1 35.5 1.0 CA C:CYS385 4.1 40.3 1.0 CA C:CYS384 4.2 37.7 1.0 O C:CYS384 4.2 36.5 1.0 NH1 C:ARG394 4.4 39.1 1.0 C C:CYS392 4.6 42.2 1.0 O C:CYS392 4.8 43.6 1.0 O C:ALA390 4.8 45.3 1.0 C C:LYS391 4.8 46.1 1.0

S.Wu, S.B.Gabelli, J.S.Sohn. Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Ppcpg(2 ,5 )Pa To Be Published.