Zinc in PDB 7uzr: Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg

All present enzymatic activity of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg:
2.7.7.86;

The structure of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg, PDB code: 7uzr was solved by S.Wu, S.B.Gabelli, J.Sohn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.01 / 2.70
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	78.534, 99, 143.091, 90, 90, 90
R / Rfree (%)	18.9 / 24.5

The structure of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg also contains other interesting chemical elements:

Manganese

(Mn)

4 atoms

The binding sites of Zinc atom in the Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg (pdb code 7uzr). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg, PDB code: 7uzr:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn602 b:41.5 occ:1.00 NE2 A:HIS378 1.9 41.7 1.0 SG A:CYS385 2.3 41.9 1.0 SG A:CYS384 2.3 38.8 1.0 SG A:CYS392 2.4 36.7 1.0 CD2 A:HIS378 2.9 40.6 1.0 CE1 A:HIS378 2.9 38.6 1.0 CB A:CYS385 3.3 42.7 1.0 CB A:CYS392 3.4 39.8 1.0 CB A:CYS384 3.5 35.7 1.0 N A:CYS392 3.7 42.5 1.0 N A:CYS385 3.8 42.9 1.0 C A:CYS384 3.8 37.3 1.0 CG A:HIS378 4.0 37.5 1.0 ND1 A:HIS378 4.0 37.0 1.0 CA A:CYS392 4.1 41.0 1.0 CA A:CYS385 4.1 40.2 1.0 CA A:CYS384 4.2 34.4 1.0 O A:CYS384 4.2 42.0 1.0 NH1 A:ARG394 4.4 41.6 1.0 C A:CYS392 4.6 41.5 1.0 O A:CYS392 4.7 44.5 1.0 O A:ALA390 4.8 48.6 1.0 C A:LYS391 4.8 45.7 1.0

Zinc binding site 2 out of 2 in the Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn602 b:41.1 occ:1.00 NE2 C:HIS378 2.0 40.9 1.0 SG C:CYS385 2.3 38.2 1.0 SG C:CYS384 2.3 36.3 1.0 SG C:CYS392 2.3 39.8 1.0 CD2 C:HIS378 2.9 36.5 1.0 CE1 C:HIS378 3.0 34.8 1.0 CB C:CYS385 3.3 41.6 1.0 CB C:CYS392 3.4 43.2 1.0 CB C:CYS384 3.5 40.0 1.0 N C:CYS385 3.7 43.7 1.0 N C:CYS392 3.8 44.0 1.0 C C:CYS384 3.8 41.3 1.0 O C:HOH711 3.8 42.9 1.0 ND1 C:HIS378 4.1 32.4 1.0 CA C:CYS385 4.1 41.7 1.0 CG C:HIS378 4.1 33.6 1.0 CA C:CYS392 4.1 41.6 1.0 CA C:CYS384 4.1 41.1 1.0 O C:CYS384 4.2 42.8 1.0 NH1 C:ARG394 4.4 43.2 1.0 C C:CYS392 4.7 39.2 1.0 O C:ALA390 4.7 58.4 1.0 O C:CYS392 4.8 45.7 1.0 C C:LYS391 4.8 44.6 1.0

S.Wu, S.B.Gabelli, J.S.Sohn. Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg To Be Published.