Zinc in PDB 7uab: Human Pro-Meprin Alpha (Zymogen State)

Enzymatic activity of Human Pro-Meprin Alpha (Zymogen State)

All present enzymatic activity of Human Pro-Meprin Alpha (Zymogen State):
3.4.24.18;

Other elements in 7uab:

The structure of Human Pro-Meprin Alpha (Zymogen State) also contains other interesting chemical elements:

Calcium (Ca) 7 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Human Pro-Meprin Alpha (Zymogen State) (pdb code 7uab). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Human Pro-Meprin Alpha (Zymogen State), PDB code: 7uab:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 7uab

Go back to Zinc Binding Sites List in 7uab
Zinc binding site 1 out of 4 in the Human Pro-Meprin Alpha (Zymogen State)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Pro-Meprin Alpha (Zymogen State) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn704

b:91.6
occ:1.00
 NE2 A:HIS165 2.0 79.5 1.0
NE2 A:HIS159 2.0 75.3 1.0
OD1 A:ASP58 2.0 90.3 1.0
OD2 A:ASP58 2.1 90.3 1.0
CG A:ASP58 2.3 90.3 1.0
NE2 A:HIS155 2.4 80.8 1.0
CE1 A:HIS165 2.9 79.5 1.0
CE1 A:HIS159 3.0 75.3 1.0
CD2 A:HIS165 3.0 79.5 1.0
CD2 A:HIS159 3.0 75.3 1.0
CE1 A:HIS155 3.3 80.8 1.0
CD2 A:HIS155 3.4 80.8 1.0
CB A:ASP58 3.7 90.3 1.0
ND1 A:HIS165 4.0 79.5 1.0
ND1 A:HIS159 4.1 75.3 1.0
CG A:HIS165 4.1 79.5 1.0
CG A:HIS159 4.1 75.3 1.0
ND1 A:HIS155 4.5 80.8 1.0
CG A:HIS155 4.5 80.8 1.0
CA A:ASP58 4.6 90.3 1.0
CG1 A:ILE59 4.8 87.6 1.0
C A:ASP58 4.8 90.3 1.0
O A:GLN56 4.9 89.4 1.0
CE A:MET212 4.9 83.0 1.0
N A:ASP58 4.9 90.3 1.0
O A:ASP58 4.9 90.3 1.0

Zinc binding site 2 out of 4 in 7uab

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Zinc binding site 2 out of 4 in the Human Pro-Meprin Alpha (Zymogen State)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human Pro-Meprin Alpha (Zymogen State) within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn703

b:91.0
occ:1.00
 NE2 D:HIS159 1.8 87.3 1.0
OD1 D:ASP58 1.9 102.5 1.0
NE2 D:HIS165 2.0 93.4 1.0
NE2 D:HIS155 2.4 95.8 1.0
CG D:ASP58 2.4 102.5 1.0
OD2 D:ASP58 2.5 102.5 1.0
CE1 D:HIS159 2.6 87.3 1.0
CD2 D:HIS159 2.8 87.3 1.0
CE1 D:HIS165 2.9 93.4 1.0
CD2 D:HIS165 3.0 93.4 1.0
CE1 D:HIS155 3.3 95.8 1.0
CD2 D:HIS155 3.4 95.8 1.0
ND1 D:HIS159 3.7 87.3 1.0
CG D:HIS159 3.8 87.3 1.0
CB D:ASP58 3.9 102.5 1.0
ND1 D:HIS165 4.0 93.4 1.0
CG D:HIS165 4.1 93.4 1.0
ND1 D:HIS155 4.4 95.8 1.0
CG D:HIS155 4.5 95.8 1.0
CE D:MET212 4.6 95.6 1.0
CA D:ASP58 4.8 102.5 1.0
CG1 D:ILE59 4.8 99.7 1.0
C D:ASP58 4.9 102.5 1.0
O D:ASP58 4.9 102.5 1.0
O D:GLN56 5.0 106.4 1.0

Zinc binding site 3 out of 4 in 7uab

Go back to Zinc Binding Sites List in 7uab
Zinc binding site 3 out of 4 in the Human Pro-Meprin Alpha (Zymogen State)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Human Pro-Meprin Alpha (Zymogen State) within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn704

b:84.4
occ:1.00
 NE2 E:HIS159 1.8 67.8 1.0
NE2 E:HIS165 1.9 71.6 1.0
OD1 E:ASP58 1.9 73.2 1.0
OD2 E:ASP58 2.4 73.2 1.0
CG E:ASP58 2.4 73.2 1.0
NE2 E:HIS155 2.5 74.3 1.0
CE1 E:HIS165 2.6 71.6 1.0
CE1 E:HIS159 2.7 67.8 1.0
CD2 E:HIS159 3.0 67.8 1.0
CD2 E:HIS165 3.1 71.6 1.0
CE1 E:HIS155 3.5 74.3 1.0
CD2 E:HIS155 3.5 74.3 1.0
ND1 E:HIS165 3.7 71.6 1.0
CB E:ASP58 3.8 73.2 1.0
ND1 E:HIS159 3.8 67.8 1.0
CG E:HIS165 4.0 71.6 1.0
CG E:HIS159 4.0 67.8 1.0
CG1 E:ILE59 4.6 68.3 1.0
ND1 E:HIS155 4.6 74.3 1.0
O E:GLN56 4.6 77.8 1.0
CA E:ASP58 4.7 73.2 1.0
CG E:HIS155 4.7 74.3 1.0
C E:ASP58 4.7 73.2 1.0
CD1 E:ILE59 4.8 68.3 1.0
N E:ASP58 4.9 73.2 1.0
O E:ASP58 4.9 73.2 1.0
CE E:MET212 4.9 77.4 1.0

Zinc binding site 4 out of 4 in 7uab

Go back to Zinc Binding Sites List in 7uab
Zinc binding site 4 out of 4 in the Human Pro-Meprin Alpha (Zymogen State)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Human Pro-Meprin Alpha (Zymogen State) within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Zn703

b:82.1
occ:1.00
 OD2 H:ASP58 1.3 74.7 1.0
NE2 H:HIS159 2.0 68.8 1.0
NE2 H:HIS165 2.1 70.7 1.0
CG H:ASP58 2.3 74.7 1.0
NE2 H:HIS155 2.6 72.7 1.0
OD1 H:ASP58 2.7 74.7 1.0
CE1 H:HIS159 2.9 68.8 1.0
CD2 H:HIS159 2.9 68.8 1.0
CE1 H:HIS165 3.0 70.7 1.0
CD2 H:HIS165 3.0 70.7 1.0
CE1 H:HIS155 3.5 72.7 1.0
CD2 H:HIS155 3.6 72.7 1.0
CB H:ASP58 3.6 74.7 1.0
ND1 H:HIS159 3.9 68.8 1.0
CG H:HIS159 4.0 68.8 1.0
ND1 H:HIS165 4.1 70.7 1.0
CG H:HIS165 4.1 70.7 1.0
CG1 H:ILE59 4.3 70.8 1.0
CA H:ASP58 4.5 74.7 1.0
N H:ASP58 4.6 74.7 1.0
ND1 H:HIS155 4.6 72.7 1.0
C H:ASP58 4.7 74.7 1.0
CG H:HIS155 4.7 72.7 1.0
CD1 H:ILE59 4.7 70.8 1.0
O H:GLN56 4.7 76.1 1.0
OE1 H:GLU156 4.8 71.3 1.0
O H:ASP58 5.0 74.7 1.0

Reference:

C.Bayly-Jones, C.J.Lupton, C.Fritz, H.Venugopal, D.Ramsbeck, M.Wermann, C.Jager, A.De Marco, S.Schilling, D.Schlenzig, J.C.Whisstock. Helical Ultrastructure of the Metalloprotease Meprin Alpha in Complex with A Small Molecule Inhibitor. Nat Commun V. 13 6178 2022.
ISSN: ESSN 2041-1723
PubMed: 36261433
DOI: 10.1038/S41467-022-33893-7
Page generated: Sat Apr 8 03:57:31 2023

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