Zinc in PDB 7sgw: Papain-Like Protease of Sars Cov-2 in Complex with PLP_SNYDER630 Inhibitor

Enzymatic activity of Papain-Like Protease of Sars Cov-2 in Complex with PLP_SNYDER630 Inhibitor

All present enzymatic activity of Papain-Like Protease of Sars Cov-2 in Complex with PLP_SNYDER630 Inhibitor:
3.4.19.12; 3.4.22.69;

Protein crystallography data

The structure of Papain-Like Protease of Sars Cov-2 in Complex with PLP_SNYDER630 Inhibitor, PDB code: 7sgw was solved by J.Osipiuk, C.Tesar, M.Endres, V.Lisnyak, S.Maki, C.Taylor, Y.Zhang, Z.Zhou, S.A.Azizi, K.Jones, R.Kathayat, S.A.Snyder, B.C.Dickinson, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.05 / 1.95
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 82.272, 82.272, 134.995, 90, 90, 120
R / Rfree (%) 17.6 / 20.7

Other elements in 7sgw:

The structure of Papain-Like Protease of Sars Cov-2 in Complex with PLP_SNYDER630 Inhibitor also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Papain-Like Protease of Sars Cov-2 in Complex with PLP_SNYDER630 Inhibitor (pdb code 7sgw). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Papain-Like Protease of Sars Cov-2 in Complex with PLP_SNYDER630 Inhibitor, PDB code: 7sgw:

Zinc binding site 1 out of 1 in 7sgw

Go back to Zinc Binding Sites List in 7sgw
Zinc binding site 1 out of 1 in the Papain-Like Protease of Sars Cov-2 in Complex with PLP_SNYDER630 Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Papain-Like Protease of Sars Cov-2 in Complex with PLP_SNYDER630 Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn502

b:82.2
occ:0.75
SG A:CYS192 2.2 92.8 1.0
SG A:CYS224 2.4 80.3 1.0
SG A:CYS189 2.5 71.3 1.0
SG A:CYS226 2.7 91.7 1.0
CB A:CYS226 3.3 87.4 1.0
CB A:CYS192 3.4 94.1 1.0
CB A:CYS189 3.4 81.9 1.0
CB A:CYS224 3.5 80.4 1.0
N A:CYS192 4.0 101.5 1.0
CG2 A:THR191 4.1 102.3 1.0
CB A:THR191 4.3 103.6 1.0
N A:CYS226 4.3 83.8 1.0
CA A:CYS192 4.3 97.5 1.0
CA A:CYS226 4.4 85.5 1.0
CA A:CYS224 4.8 79.9 1.0
CA A:CYS189 4.8 85.5 1.0
C A:THR191 4.9 101.6 1.0

Reference:

J.Osipiuk, C.Tesar, M.Endres, V.Lisnyak, S.Maki, C.Taylor, Y.Zhang, Z.Zhou, S.A.Azizi, K.Jones, R.Kathayat, S.A.Snyder, B.C.Dickinson, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid). Papain-Like Protease of Sars Cov-2 in Complex with PLP_SNYDER630 Inhibitor To Be Published.
Page generated: Fri Nov 5 17:01:06 2021

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