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Zinc in PDB 7sgu: Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with PLP_SNYDER608 Inhibitor

Enzymatic activity of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with PLP_SNYDER608 Inhibitor

All present enzymatic activity of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with PLP_SNYDER608 Inhibitor:
3.4.19.12;

Protein crystallography data

The structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with PLP_SNYDER608 Inhibitor, PDB code: 7sgu was solved by J.Osipiuk, C.Tesar, M.Endres, V.Lisnyak, S.Maki, C.Taylor, Y.Zhang, Z.Zhou, S.A.Azizi, K.Jones, R.Kathayat, S.A.Snyder, B.C.Dickinson, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.57 / 1.79
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 85.075, 85.075, 132.548, 90, 90, 120
R / Rfree (%) 16.7 / 18.8

Other elements in 7sgu:

The structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with PLP_SNYDER608 Inhibitor also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with PLP_SNYDER608 Inhibitor (pdb code 7sgu). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with PLP_SNYDER608 Inhibitor, PDB code: 7sgu:

Zinc binding site 1 out of 1 in 7sgu

Go back to Zinc Binding Sites List in 7sgu
Zinc binding site 1 out of 1 in the Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with PLP_SNYDER608 Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with PLP_SNYDER608 Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn502

b:54.4
occ:1.00
 SG A:CYS192 2.3 69.3 1.0
SG A:CYS224 2.3 55.0 1.0
SG A:CYS226 2.3 52.7 1.0
SG A:CYS189 2.4 55.3 1.0
CB A:CYS189 3.2 54.4 1.0
CB A:CYS224 3.2 52.5 1.0
CB A:CYS226 3.3 55.6 1.0
CB A:CYS192 3.3 69.5 1.0
N A:CYS192 3.9 62.9 1.0
N A:CYS226 4.1 52.9 1.0
CA A:CYS192 4.2 65.2 1.0
CA A:CYS226 4.2 51.8 1.0
CB A:THR191 4.6 65.5 1.0
CA A:CYS224 4.6 51.7 1.0
CA A:CYS189 4.7 53.9 1.0
C A:THR191 4.9 65.8 1.0
C A:CYS224 5.0 54.3 1.0

Reference:

J.Osipiuk, C.Tesar, M.Endres, V.Lisnyak, S.Maki, C.Taylor, Y.Zhang, Z.Zhou, S.A.Azizi, K.Jones, R.Kathayat, S.A.Snyder, B.C.Dickinson, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid). Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with PLP_SNYDER608 Inhibitor To Be Published.
Page generated: Wed Oct 30 11:11:42 2024

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