Zinc in PDB 7q4p: U2 Snrnp After Atp-Dependent Remodelling

The binding sites of Zinc atom in the U2 Snrnp After Atp-Dependent Remodelling (pdb code 7q4p). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the U2 Snrnp After Atp-Dependent Remodelling, PDB code: 7q4p:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in the U2 Snrnp After Atp-Dependent Remodelling


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of U2 Snrnp After Atp-Dependent Remodelling within 5.0Å range: probe atom residue distance (Å) B Occ 1:Zn501 b:74.5 occ:1.00 SG 1:CYS56 2.1 92.4 1.0 NE2 1:HIS72 2.1 96.5 1.0 ND1 1:HIS78 2.3 112.5 1.0 SG 1:CYS59 2.5 88.9 1.0 CE1 1:HIS78 3.1 112.4 1.0 CD2 1:HIS72 3.1 96.9 1.0 CE1 1:HIS72 3.1 96.6 1.0 CB 1:CYS59 3.2 89.0 1.0 CB 1:CYS56 3.3 92.6 1.0 CG 1:HIS78 3.4 112.6 1.0 CB 1:HIS78 3.8 112.9 1.0 N 1:CYS59 4.0 89.8 1.0 CA 1:CYS59 4.2 89.0 1.0 ND1 1:HIS72 4.2 97.1 1.0 CA 1:HIS78 4.2 113.5 1.0 CG 1:HIS72 4.2 97.6 1.0 NE2 1:HIS78 4.3 112.5 1.0 OG1 1:THR61 4.3 85.2 1.0 CB 1:LEU58 4.4 91.5 1.0 CD2 1:HIS78 4.4 112.6 1.0 CA 1:CYS56 4.6 92.7 1.0 CD2 1:LEU58 4.7 91.6 1.0 C 1:LEU58 4.8 90.5 1.0 CE1 1:TYR69 4.9 100.2 1.0 N 1:HIS78 5.0 113.5 1.0

Zinc binding site 2 out of 5 in the U2 Snrnp After Atp-Dependent Remodelling


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of U2 Snrnp After Atp-Dependent Remodelling within 5.0Å range: probe atom residue distance (Å) B Occ 9:Zn601 b:70.5 occ:1.00 ND1 9:HIS431 2.2 82.3 1.0 SG 9:CYS408 2.3 78.3 1.0 SG 9:CYS411 2.3 83.7 1.0 CG 9:HIS431 3.1 83.0 1.0 CE1 9:HIS425 3.1 77.7 1.0 CB 9:CYS408 3.2 79.8 1.0 CE1 9:HIS431 3.3 82.0 1.0 CB 9:HIS431 3.3 84.0 1.0 ND1 9:HIS425 3.3 77.9 1.0 CB 9:CYS411 3.4 84.0 1.0 CA 9:HIS431 3.7 85.1 1.0 N 9:CYS411 3.8 83.9 1.0 CB 9:ILE410 4.1 83.1 1.0 CA 9:CYS411 4.1 84.2 1.0 NE2 9:HIS425 4.2 77.9 1.0 C 9:ILE410 4.2 83.5 1.0 CD2 9:HIS431 4.3 82.3 1.0 NE2 9:HIS431 4.4 82.1 1.0 OH 9:TYR416 4.4 80.7 1.0 N 9:HIS431 4.4 85.6 1.0 CG 9:HIS425 4.5 78.1 1.0 CA 9:ILE410 4.6 83.2 1.0 CE2 9:TYR416 4.6 80.7 1.0 CA 9:CYS408 4.6 80.5 1.0 N 9:ILE410 4.8 83.0 1.0 O 9:ILE410 4.8 83.7 1.0 CG1 9:ILE410 4.8 83.1 1.0 CG2 9:ILE410 4.9 83.1 1.0 CZ 9:TYR416 4.9 80.6 1.0 CE1 9:PHE426 4.9 76.1 1.0 C 9:CYS408 4.9 81.2 1.0 CD2 9:HIS425 5.0 78.1 1.0 C 9:HIS431 5.0 85.6 1.0

Zinc binding site 3 out of 5 in the U2 Snrnp After Atp-Dependent Remodelling


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of U2 Snrnp After Atp-Dependent Remodelling within 5.0Å range: probe atom residue distance (Å) B Occ G:Zn201 b:42.5 occ:1.00 SG G:CYS33 2.1 55.1 1.0 SG G:CYS72 2.2 41.8 1.0 SG G:CYS75 2.3 42.1 1.0 SG G:CYS30 2.5 53.4 1.0 CB G:CYS75 3.3 42.2 1.0 CB G:CYS30 3.3 55.1 1.0 CB G:CYS33 3.3 56.7 1.0 CB G:CYS72 3.5 42.5 1.0 N G:CYS33 3.8 56.9 1.0 N G:CYS72 3.9 43.5 1.0 N G:CYS75 4.0 42.6 1.0 CA G:CYS33 4.1 57.5 1.0 CA G:CYS75 4.2 42.3 1.0 CA G:CYS72 4.2 43.3 1.0 CB G:ILE32 4.6 56.1 1.0 OG G:SER35 4.6 63.5 1.0 CA G:CYS30 4.7 56.0 1.0 O G:CYS72 4.8 43.1 1.0 C G:CYS33 4.8 58.7 1.0 C G:CYS72 4.8 43.4 1.0 C G:ILE32 4.9 56.5 1.0 CB G:SER35 4.9 63.1 1.0 N G:ASP34 5.0 60.3 1.0

Zinc binding site 4 out of 5 in the U2 Snrnp After Atp-Dependent Remodelling


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of U2 Snrnp After Atp-Dependent Remodelling within 5.0Å range: probe atom residue distance (Å) B Occ G:Zn202 b:61.1 occ:1.00 SG G:CYS46 2.2 61.9 1.0 SG G:CYS49 2.2 80.0 1.0 SG G:CYS11 2.5 75.2 1.0 SG G:CYS85 2.6 59.2 1.0 CB G:CYS11 2.8 74.2 1.0 CB G:CYS85 3.3 60.3 1.0 CB G:CYS49 3.6 80.2 1.0 CB G:CYS46 3.7 62.2 1.0 CA G:CYS11 4.3 74.2 1.0 CB G:LYS13 4.4 69.1 1.0 N G:CYS46 4.4 60.9 1.0 CA G:CYS49 4.6 80.4 1.0 N G:CYS49 4.6 78.7 1.0 CA G:CYS46 4.7 62.6 1.0 CA G:CYS85 4.7 61.0 1.0 O G:CYS85 4.7 62.0 1.0 N G:LYS13 4.8 69.1 1.0 C G:CYS11 4.8 73.1 1.0 CB G:LYS87 4.8 72.0 1.0 CD G:LYS13 4.9 70.8 1.0 C G:CYS85 5.0 61.8 1.0

Zinc binding site 5 out of 5 in the U2 Snrnp After Atp-Dependent Remodelling


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of U2 Snrnp After Atp-Dependent Remodelling within 5.0Å range: probe atom residue distance (Å) B Occ G:Zn203 b:81.1 occ:1.00 SG G:CYS61 2.0 81.0 1.0 SG G:CYS23 2.4 73.7 1.0 SG G:CYS26 2.9 77.2 1.0 SG G:CYS58 2.9 82.2 1.0 CB G:CYS23 3.3 73.3 1.0 CB G:CYS61 3.4 80.8 1.0 CB G:CYS26 3.5 76.0 1.0 CB G:CYS58 3.6 82.9 1.0 NZ G:LYS25 4.0 81.5 1.0 N G:CYS61 4.0 80.5 1.0 CE G:LYS25 4.0 81.2 1.0 N G:CYS23 4.1 71.9 1.0 CG G:LYS25 4.1 80.0 1.0 CA G:CYS61 4.3 80.7 1.0 CA G:CYS23 4.3 73.4 1.0 N G:CYS26 4.3 76.6 1.0 CA G:CYS26 4.5 75.5 1.0 N G:GLY62 4.6 80.5 1.0 CD G:LYS25 4.7 80.7 1.0 N G:GLY63 4.7 79.6 1.0 C G:CYS23 4.9 74.5 1.0 C G:CYS61 5.0 80.7 1.0

J.Tholen, M.Razew, F.Weis, W.P.Galej. Structural Basis of Branch Site Recognition By the Human Spliceosome. Science V. 375 50 2022.
ISSN: ESSN 1095-9203
PubMed: 34822310
DOI: 10.1126/SCIENCE.ABM4245