Zinc in PDB 7q4o: Substrate-Bound A-Like U2 Snrnp

The binding sites of Zinc atom in the Substrate-Bound A-Like U2 Snrnp (pdb code 7q4o). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Substrate-Bound A-Like U2 Snrnp, PDB code: 7q4o:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in the Substrate-Bound A-Like U2 Snrnp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Substrate-Bound A-Like U2 Snrnp within 5.0Å range: probe atom residue distance (Å) B Occ 1:Zn501 b:85.5 occ:1.00 SG 1:CYS59 2.1 93.0 1.0 SG 1:CYS56 2.1 95.2 1.0 NE2 1:HIS72 2.4 93.7 1.0 ND1 1:HIS78 2.6 115.8 1.0 CE1 1:HIS78 3.1 115.6 1.0 CE1 1:HIS72 3.1 93.8 1.0 CB 1:CYS59 3.2 92.6 1.0 CB 1:CYS56 3.3 94.4 1.0 CD2 1:HIS72 3.6 94.1 1.0 N 1:CYS59 3.7 93.7 1.0 CG 1:HIS78 3.7 116.0 1.0 CG2 1:THR61 4.0 82.9 1.0 C 1:LEU58 4.0 94.9 1.0 CB 1:LEU58 4.1 96.4 1.0 CA 1:CYS59 4.1 92.3 1.0 NE2 1:HIS78 4.3 115.6 1.0 ND1 1:HIS72 4.3 94.3 1.0 CB 1:HIS78 4.3 116.5 1.0 CA 1:LEU58 4.4 95.6 1.0 N 1:LEU58 4.4 95.6 1.0 O 1:LEU58 4.6 95.5 1.0 CA 1:CYS56 4.6 94.1 1.0 CG 1:HIS72 4.6 94.9 1.0 CD2 1:HIS78 4.6 115.8 1.0 CA 1:HIS78 4.8 117.5 1.0 C 1:CYS56 4.8 94.4 1.0 CD2 1:LEU58 4.9 97.3 1.0 CG 1:LEU58 5.0 96.9 1.0

Zinc binding site 2 out of 5 in the Substrate-Bound A-Like U2 Snrnp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Substrate-Bound A-Like U2 Snrnp within 5.0Å range: probe atom residue distance (Å) B Occ 9:Zn601 b:66.5 occ:1.00 NE2 9:HIS425 1.9 94.2 1.0 SG 9:CYS408 2.0 108.6 1.0 ND1 9:HIS431 2.0 98.6 1.0 SG 9:CYS411 2.8 110.4 1.0 CD2 9:HIS425 2.9 94.3 1.0 CE1 9:HIS431 2.9 98.2 1.0 CE1 9:HIS425 3.0 94.2 1.0 CB 9:CYS411 3.0 110.9 1.0 CG 9:HIS431 3.1 99.1 1.0 CB 9:CYS408 3.2 110.6 1.0 CB 9:HIS431 3.6 100.2 1.0 N 9:CYS411 3.6 110.7 1.0 CA 9:CYS411 3.8 111.3 1.0 CG 9:HIS425 4.0 94.6 1.0 ND1 9:HIS425 4.0 94.3 1.0 NE2 9:HIS431 4.0 98.5 1.0 CA 9:HIS431 4.1 101.7 1.0 CD2 9:HIS431 4.2 98.6 1.0 CB 9:ILE410 4.4 110.2 1.0 C 9:ILE410 4.4 110.6 1.0 CE1 9:PHE426 4.5 92.8 1.0 CA 9:CYS408 4.6 111.9 1.0 CD1 9:PHE426 4.6 93.3 1.0 O 9:CYS408 4.7 111.3 1.0 N 9:HIS431 4.8 102.5 1.0 CA 9:ILE410 4.8 110.4 1.0 CG2 9:ILE410 4.8 110.0 1.0 C 9:CYS408 4.8 111.4 1.0 N 9:ILE410 4.9 110.5 1.0 CE2 9:TYR416 4.9 116.1 1.0

Zinc binding site 3 out of 5 in the Substrate-Bound A-Like U2 Snrnp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Substrate-Bound A-Like U2 Snrnp within 5.0Å range: probe atom residue distance (Å) B Occ G:Zn201 b:41.2 occ:1.00 SG G:CYS33 2.1 52.9 1.0 SG G:CYS75 2.1 43.7 1.0 SG G:CYS30 2.3 49.6 1.0 SG G:CYS72 2.4 38.8 1.0 CB G:CYS30 3.3 51.9 1.0 CB G:CYS75 3.4 42.9 1.0 CB G:CYS72 3.5 39.9 1.0 CB G:CYS33 3.6 54.1 1.0 N G:CYS72 3.9 40.8 1.0 N G:CYS75 4.2 43.1 1.0 N G:CYS33 4.2 54.4 1.0 CA G:CYS72 4.3 40.5 1.0 CA G:CYS75 4.4 42.8 1.0 CA G:CYS33 4.4 54.9 1.0 CA G:CYS30 4.7 53.1 1.0 CB G:SER35 4.8 58.3 1.0 C G:CYS72 4.8 40.7 1.0 O G:CYS72 4.9 40.0 1.0 CB G:ILE32 4.9 54.5 1.0 C G:CYS33 4.9 55.7 1.0 C G:ILE32 5.0 54.4 1.0

Zinc binding site 4 out of 5 in the Substrate-Bound A-Like U2 Snrnp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Substrate-Bound A-Like U2 Snrnp within 5.0Å range: probe atom residue distance (Å) B Occ G:Zn202 b:74.6 occ:1.00 SG G:CYS46 1.5 67.2 1.0 SG G:CYS49 2.1 85.4 1.0 SG G:CYS11 2.5 73.1 1.0 SG G:CYS85 2.6 60.9 1.0 CB G:CYS11 3.3 72.9 1.0 CB G:CYS49 3.3 85.8 1.0 CB G:CYS85 3.3 61.5 1.0 CB G:CYS46 3.3 66.7 1.0 O G:HOH309 3.5 72.0 1.0 N G:CYS46 4.1 64.3 1.0 N G:CYS49 4.2 84.5 1.0 CA G:CYS46 4.2 66.9 1.0 CA G:CYS49 4.3 86.2 1.0 O G:CYS46 4.5 69.2 1.0 C G:CYS46 4.7 68.9 1.0 OE1 G:GLU48 4.7 85.4 1.0 CA G:CYS85 4.7 62.5 1.0 CA G:CYS11 4.7 73.0 1.0 CB G:LYS87 4.8 74.3 1.0 CD G:LYS13 4.9 72.2 1.0 CB G:LYS13 4.9 70.3 1.0

Zinc binding site 5 out of 5 in the Substrate-Bound A-Like U2 Snrnp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Substrate-Bound A-Like U2 Snrnp within 5.0Å range: probe atom residue distance (Å) B Occ G:Zn203 b:85.7 occ:1.00 SG G:CYS23 1.8 73.8 1.0 SG G:CYS61 2.0 86.7 1.0 SG G:CYS26 2.4 77.3 1.0 SG G:CYS58 2.7 85.1 1.0 CB G:CYS23 3.3 72.5 1.0 CB G:CYS26 3.3 75.4 1.0 CB G:CYS61 3.5 86.4 1.0 CB G:CYS58 3.5 86.1 1.0 N G:CYS23 4.1 71.4 1.0 N G:CYS61 4.1 85.5 1.0 CA G:CYS23 4.2 72.3 1.0 CA G:CYS61 4.3 86.3 1.0 N G:CYS26 4.3 75.5 1.0 CA G:CYS26 4.4 74.8 1.0 N G:GLY63 4.5 85.4 1.0 C G:CYS61 4.7 86.4 1.0 CB G:ILE60 4.8 84.2 1.0 CA G:GLY63 4.8 84.8 1.0 C G:CYS23 4.8 72.9 1.0 O G:CYS23 4.9 73.0 1.0 N G:GLY62 4.9 86.3 1.0 C G:ILE60 5.0 84.7 1.0 CA G:CYS58 5.0 86.5 1.0

J.Tholen, M.Razew, F.Weis, W.P.Galej. Structural Basis of Branch Site Recognition By the Human Spliceosome. Science V. 375 50 2022.
ISSN: ESSN 1095-9203
PubMed: 34822310
DOI: 10.1126/SCIENCE.ABM4245