Zinc in PDB 7oug: Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir

Other elements in 7oug:

The structure of Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir also contains other interesting chemical elements:

Magnesium (Mg) 4 atoms
Fluorine (F) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir (pdb code 7oug). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir, PDB code: 7oug:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 7oug

Go back to Zinc Binding Sites List in 7oug
Zinc binding site 1 out of 4 in the Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn1000

b:83.5
occ:1.00
ND1 D:HIS12 2.0 33.5 1.0
NE2 D:HIS8 2.0 22.7 1.0
CD2 D:HIS8 2.3 22.7 1.0
SG D:CYS38 2.3 61.4 1.0
SG D:CYS35 2.3 64.4 1.0
CE1 D:HIS12 2.6 33.5 1.0
CG D:HIS12 3.2 33.5 1.0
CE1 D:HIS8 3.2 22.7 1.0
CB D:CYS35 3.3 64.4 1.0
CG D:HIS8 3.5 22.7 1.0
CB D:CYS38 3.5 61.4 1.0
NE2 D:HIS12 3.8 33.5 1.0
CB D:HIS12 3.8 33.5 1.0
CA D:HIS12 3.9 33.5 1.0
ND1 D:HIS8 3.9 22.7 1.0
CD2 D:HIS12 4.0 33.5 1.0
O D:HIS8 4.2 22.7 1.0
N D:CYS38 4.6 61.4 1.0
CA D:CYS38 4.7 61.4 1.0
CB D:HIS8 4.7 22.7 1.0
C D:HIS12 4.8 33.5 1.0
CA D:CYS35 4.8 64.4 1.0
C D:HIS8 4.8 22.7 1.0
N D:HIS12 4.9 33.5 1.0

Zinc binding site 2 out of 4 in 7oug

Go back to Zinc Binding Sites List in 7oug
Zinc binding site 2 out of 4 in the Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn301

b:39.6
occ:1.00
NE2 E:HIS8 2.0 11.6 1.0
ND1 E:HIS12 2.0 7.4 1.0
SG E:CYS35 2.3 18.2 1.0
SG E:CYS38 2.3 8.9 1.0
CE1 E:HIS12 2.7 7.4 1.0
CE1 E:HIS8 2.9 11.6 1.0
CD2 E:HIS8 3.0 11.6 1.0
CG E:HIS12 3.2 7.4 1.0
CB E:CYS35 3.3 18.2 1.0
CB E:CYS38 3.7 8.9 1.0
CB E:HIS12 3.8 7.4 1.0
ND1 E:HIS8 3.9 11.6 1.0
NE2 E:HIS12 3.9 7.4 1.0
CG E:HIS8 4.0 11.6 1.0
N E:CYS38 4.0 8.9 1.0
CA E:HIS12 4.2 7.4 1.0
CD2 E:HIS12 4.2 7.4 1.0
CA E:CYS38 4.3 8.9 1.0
O E:HIS8 4.6 11.6 1.0
CA E:CYS35 4.8 18.2 1.0
CB E:ALA37 4.8 11.4 1.0
C E:ALA37 4.9 11.4 1.0
C E:HIS12 5.0 7.4 1.0

Zinc binding site 3 out of 4 in 7oug

Go back to Zinc Binding Sites List in 7oug
Zinc binding site 3 out of 4 in the Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1000

b:82.1
occ:1.00
ND1 A:HIS12 2.0 34.6 1.0
NE2 A:HIS8 2.0 24.4 1.0
CD2 A:HIS8 2.3 24.4 1.0
SG A:CYS38 2.3 58.7 1.0
SG A:CYS35 2.3 64.0 1.0
CE1 A:HIS12 2.6 34.6 1.0
CG A:HIS12 3.2 34.6 1.0
CE1 A:HIS8 3.2 24.4 1.0
CB A:CYS35 3.3 64.0 1.0
CG A:HIS8 3.5 24.4 1.0
CB A:CYS38 3.5 58.7 1.0
NE2 A:HIS12 3.8 34.6 1.0
CB A:HIS12 3.8 34.6 1.0
CA A:HIS12 3.9 34.6 1.0
ND1 A:HIS8 3.9 24.4 1.0
CD2 A:HIS12 4.0 34.6 1.0
O A:HIS8 4.2 24.4 1.0
N A:CYS38 4.6 58.7 1.0
CA A:CYS38 4.7 58.7 1.0
CB A:HIS8 4.7 24.4 1.0
C A:HIS12 4.8 34.6 1.0
CA A:CYS35 4.8 64.0 1.0
C A:HIS8 4.8 24.4 1.0
N A:HIS12 4.9 34.6 1.0

Zinc binding site 4 out of 4 in 7oug

Go back to Zinc Binding Sites List in 7oug
Zinc binding site 4 out of 4 in the Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn301

b:32.3
occ:1.00
NE2 B:HIS8 2.0 10.9 1.0
ND1 B:HIS12 2.0 11.7 1.0
SG B:CYS35 2.3 18.6 1.0
SG B:CYS38 2.3 9.3 1.0
CE1 B:HIS12 2.7 11.7 1.0
CE1 B:HIS8 2.9 10.9 1.0
CD2 B:HIS8 3.0 10.9 1.0
CG B:HIS12 3.2 11.7 1.0
CB B:CYS35 3.3 18.6 1.0
CB B:CYS38 3.7 9.3 1.0
CB B:HIS12 3.8 11.7 1.0
ND1 B:HIS8 3.9 10.9 1.0
NE2 B:HIS12 3.9 11.7 1.0
CG B:HIS8 4.0 10.9 1.0
N B:CYS38 4.0 9.3 1.0
CA B:HIS12 4.2 11.7 1.0
CD2 B:HIS12 4.2 11.7 1.0
CA B:CYS38 4.3 9.3 1.0
O B:HIS8 4.6 10.9 1.0
CA B:CYS35 4.8 18.6 1.0
CB B:ALA37 4.8 12.1 1.0
C B:ALA37 4.9 12.1 1.0
C B:HIS12 5.0 11.7 1.0

Reference:

M.S.Barski, T.Vanzo, X.Zhao, S.J.Smith, A.Ballandras-Colas, N.B.Cronin, V.E.Pye, S.H.Hughes, T.R.Burke, P.Cherepanov, G.N.Maertens. Structural Basis For the Inhibition of Htlv-1 Integration Inferred From Cryo-Em Deltaretroviral Intasome Structures Nat Commun 2021.
ISSN: ESSN 2041-1723
Page generated: Sun Aug 22 09:53:07 2021

Last articles

Zn in 7RE3
Zn in 7RDX
Zn in 7RDZ
Zn in 7RWM
Zn in 7PGU
Zn in 7PGR
Zn in 7PGT
Zn in 7PGS
Zn in 7SQE
Zn in 7RWK
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy