Zinc in PDB 7ouf: Structure of the Stlv Intasome:B56 Complex Bound to the Strand- Transfer Inhibitor XZ450

The structure of Structure of the Stlv Intasome:B56 Complex Bound to the Strand- Transfer Inhibitor XZ450 also contains other interesting chemical elements:

Magnesium	(Mg)	4 atoms
Fluorine	(F)	4 atoms

The binding sites of Zinc atom in the Structure of the Stlv Intasome:B56 Complex Bound to the Strand- Transfer Inhibitor XZ450 (pdb code 7ouf). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of the Stlv Intasome:B56 Complex Bound to the Strand- Transfer Inhibitor XZ450, PDB code: 7ouf:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structure of the Stlv Intasome:B56 Complex Bound to the Strand- Transfer Inhibitor XZ450


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the Stlv Intasome:B56 Complex Bound to the Strand- Transfer Inhibitor XZ450 within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1000 b:75.8 occ:1.00 ND1 D:HIS12 2.0 35.1 1.0 NE2 D:HIS8 2.0 24.9 1.0 CE1 D:HIS12 2.1 35.1 1.0 SG D:CYS35 2.3 67.9 1.0 SG D:CYS38 2.3 71.8 1.0 CD2 D:HIS8 2.7 24.9 1.0 CB D:CYS35 3.0 67.9 1.0 CE1 D:HIS8 3.1 24.9 1.0 CG D:HIS12 3.2 35.1 1.0 NE2 D:HIS12 3.3 35.1 1.0 CB D:CYS38 3.8 71.8 1.0 CD2 D:HIS12 3.8 35.1 1.0 CG D:HIS8 3.9 24.9 1.0 ND1 D:HIS8 4.1 24.9 1.0 CB D:HIS12 4.2 35.1 1.0 O D:HIS8 4.4 24.9 1.0 CA D:HIS12 4.4 35.1 1.0 CA D:CYS35 4.5 67.9 1.0 N D:CYS38 4.6 71.8 1.0 CA D:CYS38 4.8 71.8 1.0

Zinc binding site 2 out of 4 in the Structure of the Stlv Intasome:B56 Complex Bound to the Strand- Transfer Inhibitor XZ450


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of the Stlv Intasome:B56 Complex Bound to the Strand- Transfer Inhibitor XZ450 within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn301 b:40.4 occ:1.00 ND1 E:HIS12 2.0 10.8 1.0 NE2 E:HIS8 2.0 12.4 1.0 SG E:CYS35 2.3 18.6 1.0 SG E:CYS38 2.3 10.8 1.0 CE1 E:HIS12 2.6 10.8 1.0 CD2 E:HIS8 2.9 12.4 1.0 CE1 E:HIS8 3.0 12.4 1.0 CB E:CYS35 3.1 18.6 1.0 CG E:HIS12 3.3 10.8 1.0 CB E:CYS38 3.4 10.8 1.0 NE2 E:HIS12 3.9 10.8 1.0 CB E:HIS12 3.9 10.8 1.0 CG E:HIS8 4.0 12.4 1.0 ND1 E:HIS8 4.0 12.4 1.0 N E:CYS38 4.1 10.8 1.0 CD2 E:HIS12 4.2 10.8 1.0 CA E:HIS12 4.2 10.8 1.0 CA E:CYS38 4.3 10.8 1.0 O E:HIS8 4.5 12.4 1.0 CA E:CYS35 4.6 18.6 1.0 CB E:ALA37 5.0 10.8 1.0

Zinc binding site 3 out of 4 in the Structure of the Stlv Intasome:B56 Complex Bound to the Strand- Transfer Inhibitor XZ450


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of the Stlv Intasome:B56 Complex Bound to the Strand- Transfer Inhibitor XZ450 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1000 b:74.1 occ:1.00 ND1 A:HIS12 2.0 39.2 1.0 NE2 A:HIS8 2.0 16.0 1.0 CE1 A:HIS12 2.1 39.2 1.0 SG A:CYS35 2.3 59.7 1.0 SG A:CYS38 2.3 61.2 1.0 CD2 A:HIS8 2.7 16.0 1.0 CB A:CYS35 3.0 59.7 1.0 CE1 A:HIS8 3.1 16.0 1.0 CG A:HIS12 3.2 39.2 1.0 NE2 A:HIS12 3.3 39.2 1.0 CB A:CYS38 3.8 61.2 1.0 CD2 A:HIS12 3.8 39.2 1.0 CG A:HIS8 3.9 16.0 1.0 ND1 A:HIS8 4.1 16.0 1.0 CB A:HIS12 4.2 39.2 1.0 O A:HIS8 4.4 16.0 1.0 CA A:HIS12 4.4 39.2 1.0 CA A:CYS35 4.5 59.7 1.0 N A:CYS38 4.6 61.2 1.0 CA A:CYS38 4.8 61.2 1.0

Zinc binding site 4 out of 4 in the Structure of the Stlv Intasome:B56 Complex Bound to the Strand- Transfer Inhibitor XZ450


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of the Stlv Intasome:B56 Complex Bound to the Strand- Transfer Inhibitor XZ450 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn301 b:39.9 occ:1.00 ND1 B:HIS12 2.0 10.1 1.0 NE2 B:HIS8 2.0 12.5 1.0 SG B:CYS35 2.3 23.5 1.0 SG B:CYS38 2.3 10.8 1.0 CE1 B:HIS12 2.6 10.1 1.0 CD2 B:HIS8 2.9 12.5 1.0 CE1 B:HIS8 3.0 12.5 1.0 CB B:CYS35 3.1 23.5 1.0 CG B:HIS12 3.3 10.1 1.0 CB B:CYS38 3.4 10.8 1.0 NE2 B:HIS12 3.9 10.1 1.0 CB B:HIS12 3.9 10.1 1.0 CG B:HIS8 4.0 12.5 1.0 ND1 B:HIS8 4.0 12.5 1.0 N B:CYS38 4.1 10.8 1.0 CD2 B:HIS12 4.2 10.1 1.0 CA B:HIS12 4.2 10.1 1.0 CA B:CYS38 4.3 10.8 1.0 O B:HIS8 4.5 12.5 1.0 CA B:CYS35 4.6 23.5 1.0 CB B:ALA37 5.0 10.8 1.0

M.S.Barski, T.Vanzo, X.Zhao, S.J.Smith, A.Ballandras-Colas, N.B.Cronin, V.E.Pye, S.H.Hughes, T.R.Burke, P.Cherepanov, G.N.Maertens. Structural Basis For the Inhibition of Htlv-1 Integration Inferred From Cryo-Em Deltaretroviral Intasome Structures Nat Commun 2021.
ISSN: ESSN 2041-1723