Zinc in PDB 7kcb: Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol

The structure of Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol also contains other interesting chemical elements:

Fluorine

(F)

12 atoms

The binding sites of Zinc atom in the Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol (pdb code 7kcb). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 8 binding sites of Zinc where determined in the Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol, PDB code: 7kcb:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Zinc binding site 1 out of 8 in the Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:61.1 occ:1.00 NE2 A:HIS66 2.0 41.7 1.0 SG A:CYS43 2.2 44.6 1.0 SG A:CYS153 2.2 39.1 1.0 O A:ETF404 2.3 39.2 1.0 CB A:CYS43 2.9 44.6 1.0 CE1 A:HIS66 2.9 41.7 1.0 CD2 A:HIS66 3.1 41.7 1.0 CB A:CYS153 3.4 39.1 1.0 C2 A:ETF404 3.5 39.2 1.0 C5N A:NAD403 3.5 37.1 1.0 CB A:THR45 3.7 42.0 1.0 OE2 A:GLU67 3.8 42.7 1.0 OG1 A:THR45 3.9 42.0 1.0 ND1 A:HIS66 4.1 41.7 1.0 C6N A:NAD403 4.1 37.1 1.0 CG A:HIS66 4.2 41.7 1.0 CA A:CYS43 4.4 44.6 1.0 C4N A:NAD403 4.4 37.1 1.0 CG2 A:THR45 4.5 42.0 1.0 F3 A:ETF404 4.5 39.2 1.0 C1 A:ETF404 4.5 39.2 1.0 NH2 A:ARG340 4.6 44.6 1.0 N A:THR45 4.6 42.0 1.0 CA A:CYS153 4.7 39.1 1.0 CD A:GLU67 4.8 42.7 1.0 CA A:THR45 4.8 42.0 1.0 C A:CYS153 4.9 39.1 1.0 CG A:GLU67 4.9 42.7 1.0

Zinc binding site 2 out of 8 in the Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn402 b:63.7 occ:1.00 SG A:CYS111 2.2 44.3 1.0 SG A:CYS97 2.3 47.8 1.0 SG A:CYS100 2.3 42.7 1.0 SG A:CYS103 2.3 40.4 1.0 CB A:CYS111 3.3 44.3 1.0 CB A:CYS97 3.4 47.8 1.0 CB A:CYS103 3.4 40.4 1.0 CB A:CYS100 3.4 42.7 1.0 N A:CYS97 3.7 47.8 1.0 N A:MET98 3.9 47.8 1.0 N A:CYS100 3.9 42.7 1.0 CA A:CYS97 4.0 47.8 1.0 C A:CYS97 4.2 47.8 1.0 CA A:CYS100 4.3 42.7 1.0 N A:ALA99 4.4 45.1 1.0 N A:CYS103 4.4 40.4 1.0 CA A:CYS111 4.4 44.3 1.0 CA A:CYS103 4.5 40.4 1.0 ND1 A:HIS113 4.8 48.9 1.0 CB A:SER96 4.8 47.6 1.0 CA A:MET98 4.8 47.8 1.0 CD A:PRO112 4.9 47.0 1.0 C A:SER96 4.9 47.6 1.0 C A:CYS100 4.9 42.7 1.0 O A:CYS100 4.9 42.7 1.0 C A:CYS111 5.0 44.3 1.0

Zinc binding site 3 out of 8 in the Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn401 b:61.2 occ:1.00 NE2 B:HIS66 2.0 41.7 1.0 SG B:CYS43 2.2 44.9 1.0 SG B:CYS153 2.2 39.1 1.0 O B:ETF404 2.3 39.2 1.0 CB B:CYS43 2.9 44.9 1.0 CE1 B:HIS66 2.9 41.7 1.0 CD2 B:HIS66 3.1 41.7 1.0 CB B:CYS153 3.4 39.1 1.0 C2 B:ETF404 3.5 39.2 1.0 C5N B:NAD403 3.5 37.2 1.0 CB B:THR45 3.7 42.1 1.0 OE2 B:GLU67 3.8 42.7 1.0 OG1 B:THR45 3.9 42.1 1.0 ND1 B:HIS66 4.1 41.7 1.0 C6N B:NAD403 4.1 37.2 1.0 CG B:HIS66 4.2 41.7 1.0 CA B:CYS43 4.4 44.9 1.0 C4N B:NAD403 4.4 37.2 1.0 CG2 B:THR45 4.5 42.1 1.0 F3 B:ETF404 4.5 39.2 1.0 C1 B:ETF404 4.5 39.2 1.0 NH2 B:ARG340 4.6 44.6 1.0 N B:THR45 4.6 42.1 1.0 CA B:CYS153 4.7 39.1 1.0 CD B:GLU67 4.8 42.7 1.0 CA B:THR45 4.8 42.1 1.0 C B:CYS153 4.9 39.1 1.0 CG B:GLU67 4.9 42.7 1.0

Zinc binding site 4 out of 8 in the Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn402 b:63.7 occ:1.00 SG B:CYS111 2.2 44.4 1.0 SG B:CYS97 2.3 47.9 1.0 SG B:CYS100 2.3 42.8 1.0 SG B:CYS103 2.3 40.3 1.0 CB B:CYS111 3.3 44.4 1.0 CB B:CYS97 3.4 47.9 1.0 CB B:CYS103 3.4 40.3 1.0 CB B:CYS100 3.4 42.8 1.0 N B:CYS97 3.7 47.9 1.0 N B:MET98 3.9 47.5 1.0 N B:CYS100 3.9 42.8 1.0 CA B:CYS97 4.0 47.9 1.0 C B:CYS97 4.2 47.9 1.0 CA B:CYS100 4.3 42.8 1.0 N B:ALA99 4.4 45.1 1.0 N B:CYS103 4.4 40.3 1.0 CA B:CYS111 4.4 44.4 1.0 CA B:CYS103 4.5 40.3 1.0 ND1 B:HIS113 4.8 48.9 1.0 CB B:SER96 4.8 47.6 1.0 CA B:MET98 4.8 47.5 1.0 CD B:PRO112 4.9 47.0 1.0 C B:SER96 4.9 47.6 1.0 C B:CYS100 4.9 42.8 1.0 O B:CYS100 4.9 42.8 1.0 C B:CYS111 5.0 44.4 1.0

Zinc binding site 5 out of 8 in the Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn401 b:61.6 occ:1.00 NE2 C:HIS66 2.0 41.8 1.0 SG C:CYS43 2.2 45.1 1.0 SG C:CYS153 2.2 39.4 1.0 O C:ETF404 2.3 39.4 1.0 CB C:CYS43 2.9 45.1 1.0 CE1 C:HIS66 2.9 41.8 1.0 CD2 C:HIS66 3.1 41.8 1.0 CB C:CYS153 3.4 39.4 1.0 C2 C:ETF404 3.5 39.4 1.0 C5N C:NAD403 3.5 37.4 1.0 CB C:THR45 3.7 42.2 1.0 OE2 C:GLU67 3.8 42.8 1.0 OG1 C:THR45 3.9 42.2 1.0 ND1 C:HIS66 4.1 41.8 1.0 C6N C:NAD403 4.1 37.4 1.0 CG C:HIS66 4.2 41.8 1.0 CA C:CYS43 4.4 45.1 1.0 C4N C:NAD403 4.4 37.4 1.0 CG2 C:THR45 4.5 42.2 1.0 F3 C:ETF404 4.5 39.4 1.0 C1 C:ETF404 4.5 39.4 1.0 NH2 C:ARG340 4.6 44.9 1.0 N C:THR45 4.6 42.2 1.0 CA C:CYS153 4.7 39.4 1.0 CD C:GLU67 4.8 42.8 1.0 CA C:THR45 4.8 42.2 1.0 C C:CYS153 4.9 39.4 1.0 CG C:GLU67 4.9 42.8 1.0

Zinc binding site 6 out of 8 in the Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn402 b:64.5 occ:1.00 SG C:CYS111 2.2 44.2 1.0 SG C:CYS97 2.3 48.0 1.0 SG C:CYS100 2.3 42.9 1.0 SG C:CYS103 2.3 40.3 1.0 CB C:CYS111 3.3 44.2 1.0 CB C:CYS97 3.4 48.0 1.0 CB C:CYS103 3.4 40.3 1.0 CB C:CYS100 3.4 42.9 1.0 N C:CYS97 3.7 48.0 1.0 N C:MET98 3.9 47.8 1.0 N C:CYS100 3.9 42.9 1.0 CA C:CYS97 4.0 48.0 1.0 C C:CYS97 4.2 48.0 1.0 CA C:CYS100 4.3 42.9 1.0 N C:ALA99 4.4 45.3 1.0 N C:CYS103 4.4 40.3 1.0 CA C:CYS111 4.4 44.2 1.0 CA C:CYS103 4.5 40.3 1.0 ND1 C:HIS113 4.8 48.8 1.0 CB C:SER96 4.8 47.9 1.0 CA C:MET98 4.8 47.8 1.0 CD C:PRO112 4.9 46.7 1.0 C C:SER96 4.9 47.9 1.0 C C:CYS100 4.9 42.9 1.0 O C:CYS100 4.9 42.9 1.0 C C:CYS111 5.0 44.2 1.0

Zinc binding site 7 out of 8 in the Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn401 b:60.4 occ:1.00 NE2 D:HIS66 2.0 41.3 1.0 SG D:CYS43 2.2 44.6 1.0 SG D:CYS153 2.2 38.7 1.0 O D:ETF404 2.3 39.0 1.0 CB D:CYS43 2.9 44.6 1.0 CE1 D:HIS66 2.9 41.3 1.0 CD2 D:HIS66 3.1 41.3 1.0 CB D:CYS153 3.4 38.7 1.0 C2 D:ETF404 3.5 39.0 1.0 C5N D:NAD403 3.5 36.8 1.0 CB D:THR45 3.7 41.8 1.0 OE2 D:GLU67 3.8 42.2 1.0 OG1 D:THR45 3.9 41.8 1.0 ND1 D:HIS66 4.1 41.3 1.0 C6N D:NAD403 4.1 36.8 1.0 CG D:HIS66 4.2 41.3 1.0 CA D:CYS43 4.4 44.6 1.0 C4N D:NAD403 4.4 36.8 1.0 CG2 D:THR45 4.5 41.8 1.0 F3 D:ETF404 4.5 39.0 1.0 C1 D:ETF404 4.5 39.0 1.0 NH2 D:ARG340 4.6 44.6 1.0 N D:THR45 4.6 41.8 1.0 CA D:CYS153 4.7 38.7 1.0 CD D:GLU67 4.8 42.2 1.0 CA D:THR45 4.8 41.8 1.0 C D:CYS153 4.9 38.7 1.0 CG D:GLU67 4.9 42.2 1.0

Zinc binding site 8 out of 8 in the Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with Nad+ and Trifluoroethanol within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn402 b:64.0 occ:1.00 SG D:CYS111 2.2 44.1 1.0 SG D:CYS97 2.3 47.7 1.0 SG D:CYS100 2.3 42.8 1.0 SG D:CYS103 2.3 40.4 1.0 CB D:CYS111 3.3 44.1 1.0 CB D:CYS97 3.4 47.7 1.0 CB D:CYS103 3.4 40.4 1.0 CB D:CYS100 3.4 42.8 1.0 N D:CYS97 3.7 47.7 1.0 N D:MET98 3.9 47.6 1.0 N D:CYS100 3.9 42.8 1.0 CA D:CYS97 4.0 47.7 1.0 C D:CYS97 4.2 47.7 1.0 CA D:CYS100 4.3 42.8 1.0 N D:ALA99 4.4 45.2 1.0 N D:CYS103 4.4 40.4 1.0 CA D:CYS111 4.4 44.1 1.0 CA D:CYS103 4.5 40.4 1.0 ND1 D:HIS113 4.8 48.8 1.0 CB D:SER96 4.8 47.5 1.0 CA D:MET98 4.8 47.6 1.0 CD D:PRO112 4.9 46.7 1.0 C D:SER96 4.9 47.5 1.0 C D:CYS100 4.9 42.8 1.0 O D:CYS100 4.9 42.8 1.0 C D:CYS111 5.0 44.1 1.0

S.R.Guntupalli, Z.Li, L.Chang, B.V.Plapp, R.Subramanian. Cryo-Electron Microscopy Structures of Yeast Alcohol Dehydrogenase. Biochemistry V. 60 663 2021.
ISSN: ISSN 0006-2960
PubMed: 33620215
DOI: 10.1021/ACS.BIOCHEM.0C00921