Zinc in PDB 7kbt: Factor VIII in Complex with the Anti-C2 Domain Antibody, G99

Protein crystallography data

The structure of Factor VIII in Complex with the Anti-C2 Domain Antibody, G99, PDB code: 7kbt was solved by E.K.Ronayne, J.Gish, C.Wilson, S.Peters, H.T.Spencer, P.C.Spiegel, K.C.Childers, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.48 / 4.15
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 132.243, 132.243, 380.029, 90.00, 90.00, 90.00
R / Rfree (%) 30 / 33.8

Other elements in 7kbt:

The structure of Factor VIII in Complex with the Anti-C2 Domain Antibody, G99 also contains other interesting chemical elements:

Copper (Cu) 1 atom
Calcium (Ca) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Factor VIII in Complex with the Anti-C2 Domain Antibody, G99 (pdb code 7kbt). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Factor VIII in Complex with the Anti-C2 Domain Antibody, G99, PDB code: 7kbt:

Zinc binding site 1 out of 1 in 7kbt

Go back to Zinc Binding Sites List in 7kbt
Zinc binding site 1 out of 1 in the Factor VIII in Complex with the Anti-C2 Domain Antibody, G99


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Factor VIII in Complex with the Anti-C2 Domain Antibody, G99 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn2403

b:0.2
occ:1.00
ND1 A:HIS318 2.3 0.5 1.0
ND1 A:HIS268 2.3 0.3 1.0
SG A:CYS311 2.5 0.3 1.0
CE1 A:HIS268 2.8 0.0 1.0
CG A:HIS318 3.0 0.2 1.0
CB A:HIS318 3.1 0.4 1.0
CB A:CYS311 3.3 0.9 1.0
CE1 A:HIS318 3.3 1.0 1.0
CG2 A:ILE313 3.5 0.6 1.0
CG A:HIS268 3.6 0.7 1.0
CG A:MET321 3.8 0.6 1.0
CA A:HIS318 3.9 0.7 1.0
NE2 A:HIS268 4.0 0.6 1.0
CD2 A:HIS318 4.1 0.1 1.0
CB A:HIS268 4.2 0.2 1.0
NE2 A:HIS318 4.3 0.1 1.0
CE A:MET321 4.4 0.3 1.0
C A:HIS318 4.4 0.5 1.0
CD2 A:HIS268 4.4 0.8 1.0
CB A:MET321 4.6 0.8 1.0
CA A:HIS268 4.6 0.5 1.0
O A:VAL267 4.7 0.1 1.0
O A:HIS318 4.7 0.6 1.0
SD A:MET321 4.7 0.3 1.0
CA A:CYS311 4.7 0.7 1.0
CB A:ILE313 4.8 0.6 1.0
N A:GLY319 5.0 0.9 1.0

Reference:

E.K.Ronayne, J.Gish, C.Wilson, S.Peters, H.T.Spencer, P.C.Spiegel, K.C.Childers. Structure of A Bioengineered Variant of Factor VIII in Complex with the Anti-C2 Domain, Non-Classical Antibody Inhibitor, G99 To Be Published.
Page generated: Wed Dec 16 14:03:47 2020

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