Zinc in PDB 7jz0: Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1) and S-Adenosyl-L-Homocysteine (Sah).

The structure of Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1) and S-Adenosyl-L-Homocysteine (Sah)., PDB code: 7jz0 was solved by G.Minasov, L.Shuvalova, M.Rosas-Lemus, O.Kiryukhina, J.S.Brunzelle, K.J.F.Satchell, Center For Structural Genomics Of Infectious Diseases(Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.15
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	167.238, 167.238, 98.867, 90.00, 90.00, 120.00
R / Rfree (%)	17.3 / 19.8

The structure of Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1) and S-Adenosyl-L-Homocysteine (Sah). also contains other interesting chemical elements:

Chlorine	(Cl)	7 atoms
Sodium	(Na)	4 atoms

The binding sites of Zinc atom in the Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1) and S-Adenosyl-L-Homocysteine (Sah). (pdb code 7jz0). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1) and S-Adenosyl-L-Homocysteine (Sah)., PDB code: 7jz0:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1) and S-Adenosyl-L-Homocysteine (Sah).


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1) and S-Adenosyl-L-Homocysteine (Sah). within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn4401 b:63.2 occ:1.00 NE2 B:HIS4336 2.0 90.0 1.0 SG B:CYS4327 2.3 62.5 1.0 SG B:CYS4343 2.3 72.7 1.0 SG B:CYS4330 2.3 67.8 1.0 CD2 B:HIS4336 3.0 83.2 1.0 CE1 B:HIS4336 3.0 86.9 1.0 CB B:CYS4327 3.2 64.7 1.0 CB B:CYS4343 3.3 76.5 1.0 CB B:CYS4330 3.4 65.5 1.0 N B:CYS4330 3.6 65.0 1.0 CA B:CYS4330 3.9 64.1 1.0 ND1 B:HIS4336 4.1 87.6 1.0 CG B:HIS4336 4.1 86.8 1.0 CA B:CYS4343 4.5 79.7 1.0 CB B:TYR4329 4.6 71.7 1.0 C B:TYR4329 4.6 67.9 1.0 CA B:CYS4327 4.6 64.2 1.0 CB B:LYS4346 4.8 64.4 1.0 O B:CYS4327 4.9 66.9 1.0 CA B:TYR4329 5.0 68.7 1.0 C B:CYS4327 5.0 68.5 1.0 N B:LYS4346 5.0 59.4 1.0

Zinc binding site 2 out of 4 in the Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1) and S-Adenosyl-L-Homocysteine (Sah).


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1) and S-Adenosyl-L-Homocysteine (Sah). within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn4402 b:71.9 occ:0.75 SG B:CYS4381 2.3 87.7 1.0 SG B:CYS4383 2.3 0.1 1.0 SG B:CYS4373 2.3 0.1 1.0 SG B:CYS4370 2.3 98.0 1.0 CB B:CYS4370 3.3 97.9 1.0 CB B:CYS4373 3.3 0.3 1.0 CB B:CYS4383 3.4 0.6 1.0 CB B:CYS4381 3.4 92.1 1.0 N B:CYS4373 3.7 0.4 1.0 CA B:CYS4381 4.0 90.2 1.0 CA B:CYS4373 4.1 98.4 1.0 N B:CYS4383 4.1 0.3 1.0 CA B:CYS4383 4.3 0.2 1.0 C B:CYS4381 4.5 89.3 1.0 N B:SER4382 4.5 89.4 1.0 CB B:VAL4372 4.6 0.2 1.0 CA B:CYS4370 4.7 96.5 1.0 NZ B:LYS4377 4.8 0.2 1.0 C B:VAL4372 4.9 0.9 1.0 CG1 B:VAL4372 5.0 0.7 1.0 N B:GLY4374 5.0 87.2 1.0 C B:CYS4373 5.0 91.6 1.0

Zinc binding site 3 out of 4 in the Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1) and S-Adenosyl-L-Homocysteine (Sah).


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1) and S-Adenosyl-L-Homocysteine (Sah). within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn4401 b:57.6 occ:1.00 NE2 D:HIS4336 2.1 77.8 1.0 SG D:CYS4327 2.3 59.5 1.0 SG D:CYS4343 2.3 61.2 1.0 SG D:CYS4330 2.3 64.2 1.0 CD2 D:HIS4336 3.1 74.7 1.0 CE1 D:HIS4336 3.1 74.1 1.0 CB D:CYS4327 3.2 60.4 1.0 CB D:CYS4343 3.3 69.2 1.0 CB D:CYS4330 3.4 63.7 1.0 N D:CYS4330 3.6 64.6 1.0 CA D:CYS4330 3.9 62.5 1.0 ND1 D:HIS4336 4.2 78.1 1.0 CG D:HIS4336 4.2 81.6 1.0 CA D:CYS4343 4.4 74.4 1.0 CB D:TYR4329 4.5 72.0 1.0 C D:TYR4329 4.5 65.7 1.0 O D:HOH4540 4.5 43.0 0.5 CA D:CYS4327 4.6 58.3 1.0 CB D:LYS4346 4.9 56.4 1.0 O D:CYS4327 4.9 58.2 1.0 CA D:TYR4329 4.9 68.4 1.0 C D:CYS4327 5.0 60.2 1.0

Zinc binding site 4 out of 4 in the Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1) and S-Adenosyl-L-Homocysteine (Sah).


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1) and S-Adenosyl-L-Homocysteine (Sah). within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn4402 b:79.8 occ:0.75 SG D:CYS4373 2.3 95.4 1.0 SG D:CYS4370 2.3 97.2 1.0 SG D:CYS4381 2.3 94.6 1.0 SG D:CYS4383 2.3 0.1 1.0 CB D:CYS4370 3.3 95.0 1.0 CB D:CYS4383 3.4 0.0 1.0 CB D:CYS4373 3.4 96.4 1.0 CB D:CYS4381 3.5 99.6 1.0 N D:CYS4373 3.7 97.8 1.0 CA D:CYS4381 4.0 97.4 1.0 N D:CYS4383 4.0 0.6 1.0 CA D:CYS4373 4.1 92.4 1.0 CA D:CYS4383 4.3 0.8 1.0 N D:SER4382 4.3 0.1 1.0 CB D:VAL4372 4.4 0.2 1.0 C D:CYS4381 4.5 0.4 1.0 CA D:CYS4370 4.7 91.4 1.0 C D:VAL4372 4.8 98.7 1.0 CG1 D:VAL4372 4.9 0.6 1.0 N D:GLY4374 4.9 81.9 1.0 CA D:VAL4372 5.0 0.0 1.0 C D:CYS4373 5.0 85.8 1.0

G.Minasov, L.Shuvalova, M.Rosas-Lemus, O.Kiryukhina, J.S.Brunzelle, K.J.F.Satchell, Center For Structural Genomics Of Infectious Diseases(Csgid). Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1) and S-Adenosyl-L-Homocysteine (Sah). To Be Published.