Atomistry » Zinc » PDB 7gqu-7h48 » 7h30
Atomistry »
  Zinc »
    PDB 7gqu-7h48 »
      7h30 »

Zinc in PDB 7h30: Group Deposition For Crystallographic Fragment Screening of Coxsackievirus A16 (G-10) 2A Protease -- Crystal Structure of Coxsackievirus A16 (G-10) 2A Protease in Complex with Z437516460 (A71EV2A-X0237)

Enzymatic activity of Group Deposition For Crystallographic Fragment Screening of Coxsackievirus A16 (G-10) 2A Protease -- Crystal Structure of Coxsackievirus A16 (G-10) 2A Protease in Complex with Z437516460 (A71EV2A-X0237)

All present enzymatic activity of Group Deposition For Crystallographic Fragment Screening of Coxsackievirus A16 (G-10) 2A Protease -- Crystal Structure of Coxsackievirus A16 (G-10) 2A Protease in Complex with Z437516460 (A71EV2A-X0237):
3.4.22.29;

Protein crystallography data

The structure of Group Deposition For Crystallographic Fragment Screening of Coxsackievirus A16 (G-10) 2A Protease -- Crystal Structure of Coxsackievirus A16 (G-10) 2A Protease in Complex with Z437516460 (A71EV2A-X0237), PDB code: 7h30 was solved by R.M.Lithgo, M.Fairhead, L.Koekemoer, B.H.Balcomb, E.Capkin, A.V.Chandran, M.Golding, A.S.Godoy, J.C.Aschenbrenner, P.G.Marples, X.Ni, W.Thompson, C.W.E.Tomlinson, C.Wild, M.Winokan, M.-A.E.Xavier, D.Fearon, F.Von Delft, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 38.92 / 1.34
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 86.4, 56.44, 64.71, 90, 94.43, 90
R / Rfree (%) 18.6 / 22.1

Zinc Binding Sites:

The binding sites of Zinc atom in the Group Deposition For Crystallographic Fragment Screening of Coxsackievirus A16 (G-10) 2A Protease -- Crystal Structure of Coxsackievirus A16 (G-10) 2A Protease in Complex with Z437516460 (A71EV2A-X0237) (pdb code 7h30). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Group Deposition For Crystallographic Fragment Screening of Coxsackievirus A16 (G-10) 2A Protease -- Crystal Structure of Coxsackievirus A16 (G-10) 2A Protease in Complex with Z437516460 (A71EV2A-X0237), PDB code: 7h30:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 7h30

Go back to Zinc Binding Sites List in 7h30
Zinc binding site 1 out of 2 in the Group Deposition For Crystallographic Fragment Screening of Coxsackievirus A16 (G-10) 2A Protease -- Crystal Structure of Coxsackievirus A16 (G-10) 2A Protease in Complex with Z437516460 (A71EV2A-X0237)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Group Deposition For Crystallographic Fragment Screening of Coxsackievirus A16 (G-10) 2A Protease -- Crystal Structure of Coxsackievirus A16 (G-10) 2A Protease in Complex with Z437516460 (A71EV2A-X0237) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn201

b:16.4
occ:1.00
ND1 A:HIS118 2.1 16.5 1.0
SG A:CYS116 2.3 14.6 1.0
SG A:CYS58 2.3 18.0 1.0
SG A:CYS56 2.4 16.7 1.0
CE1 A:HIS118 3.0 20.2 1.0
CG A:HIS118 3.1 17.9 1.0
CB A:CYS58 3.2 16.8 1.0
CB A:CYS56 3.3 14.3 1.0
CB A:CYS116 3.4 12.5 1.0
CB A:HIS118 3.5 16.8 1.0
N A:HIS118 3.9 17.0 1.0
NE2 A:HIS118 4.1 19.2 1.0
CD2 A:HIS118 4.2 18.7 1.0
N A:CYS58 4.3 16.7 1.0
CA A:CYS58 4.3 15.2 1.0
CA A:HIS118 4.3 18.0 1.0
N A:GLN117 4.5 17.7 1.0
CB A:ALA54 4.5 16.7 1.0
O A:HOH330 4.5 37.6 1.0
CG A:GLN117 4.6 21.9 1.0
CA A:CYS116 4.6 15.1 1.0
O A:HOH466 4.6 25.4 1.0
CA A:CYS56 4.7 16.4 1.0
C A:CYS116 4.7 15.5 1.0
C A:GLN117 5.0 18.5 1.0

Zinc binding site 2 out of 2 in 7h30

Go back to Zinc Binding Sites List in 7h30
Zinc binding site 2 out of 2 in the Group Deposition For Crystallographic Fragment Screening of Coxsackievirus A16 (G-10) 2A Protease -- Crystal Structure of Coxsackievirus A16 (G-10) 2A Protease in Complex with Z437516460 (A71EV2A-X0237)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Group Deposition For Crystallographic Fragment Screening of Coxsackievirus A16 (G-10) 2A Protease -- Crystal Structure of Coxsackievirus A16 (G-10) 2A Protease in Complex with Z437516460 (A71EV2A-X0237) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn202

b:18.2
occ:1.00
ND1 B:HIS118 2.1 18.8 1.0
SG B:CYS116 2.2 16.4 1.0
SG B:CYS58 2.3 19.8 1.0
SG B:CYS56 2.4 18.0 1.0
CE1 B:HIS118 3.0 24.3 1.0
CB B:CYS58 3.1 21.0 1.0
CG B:HIS118 3.1 19.3 1.0
CB B:CYS56 3.3 16.2 1.0
CB B:CYS116 3.3 14.0 1.0
CB B:HIS118 3.5 18.4 1.0
N B:HIS118 3.9 19.5 1.0
NE2 B:HIS118 4.2 22.5 1.0
N B:CYS58 4.2 20.4 1.0
CA B:CYS58 4.2 18.9 1.0
CD2 B:HIS118 4.2 22.2 1.0
CG B:GLN117 4.3 25.6 1.0
CA B:HIS118 4.4 18.1 1.0
N B:GLN117 4.5 20.4 1.0
CB B:ALA54 4.5 15.9 1.0
CA B:CYS116 4.6 16.2 1.0
O B:HOH458 4.7 29.6 1.0
C B:CYS116 4.7 19.2 1.0
CA B:CYS56 4.7 18.1 1.0
C B:GLN117 4.9 23.1 1.0

Reference:

R.M.Lithgo, M.Fairhead, L.Koekemoer, B.H.Balcomb, E.Capkin, A.V.Chandran, M.Golding, A.S.Godoy, J.C.Aschenbrenner, P.G.Marples, X.Ni, W.Thompson, C.W.E.Tomlinson, C.Wild, M.Winokan, M.-A.E.Xavier, D.Fearon, F.Von Delft. Group Deposition For Crystallographic Fragment Screening of Coxsackievirus A16 (G-10) 2A Protease To Be Published.
Page generated: Tue Oct 29 20:43:39 2024

Last articles

Zn in 7Z15
Zn in 7YZZ
Zn in 7Z10
Zn in 7Z0U
Zn in 7YUI
Zn in 7Z0R
Zn in 7Z00
Zn in 7Z0I
Zn in 7YX8
Zn in 7YXM
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy