Zinc in PDB 7d17: Crystal Structure of Macrostomum Lignano Glutaminyl Cyclase

All present enzymatic activity of Crystal Structure of Macrostomum Lignano Glutaminyl Cyclase:
2.3.2.5;

The structure of Crystal Structure of Macrostomum Lignano Glutaminyl Cyclase, PDB code: 7d17 was solved by K.-F.Huang, J.-S.Huang, M.-L.Wu, W.-L.Hsieh, A.H.-J.Wang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.47 / 3.00
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	84.855, 71.671, 49.902, 90, 90, 90
R / Rfree (%)	18.7 / 23.3

The binding sites of Zinc atom in the Crystal Structure of Macrostomum Lignano Glutaminyl Cyclase (pdb code 7d17). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Macrostomum Lignano Glutaminyl Cyclase, PDB code: 7d17:

Zinc binding site 1 out of 1 in the Crystal Structure of Macrostomum Lignano Glutaminyl Cyclase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Macrostomum Lignano Glutaminyl Cyclase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:33.9 occ:1.00 OE2 A:GLU189 2.0 34.0 1.0 O A:HOH506 2.0 19.1 1.0 NE2 A:HIS323 2.1 32.5 1.0 OD2 A:ASP148 2.1 57.2 1.0 CD A:GLU189 2.7 31.4 1.0 CG A:ASP148 2.8 42.9 1.0 OD1 A:ASP148 2.8 33.1 1.0 OE1 A:GLU189 2.9 39.2 1.0 CD2 A:HIS323 3.0 32.2 1.0 CE1 A:HIS323 3.1 37.3 1.0 NE1 A:TRP322 3.7 39.9 1.0 CG A:GLU189 3.9 39.8 1.0 CG A:HIS323 4.1 25.8 1.0 ND1 A:HIS323 4.2 33.5 1.0 CB A:ASP148 4.3 40.2 1.0 CE2 A:TRP322 4.4 44.1 1.0 CD1 A:TRP322 4.5 39.9 1.0 CZ2 A:TRP322 4.6 30.8 1.0

K.F.Huang, J.S.Huang, M.L.Wu, W.L.Hsieh, K.C.Hsu, H.L.Hsu, T.P.Ko, A.H-J Wang. A Unique Carboxylic-Acid Hydrogen-Bond Network (Cahbn) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes. J.Mol.Biol. 66960 2021.
ISSN: ESSN 1089-8638
PubMed: 33774034
DOI: 10.1016/J.JMB.2021.166960