Zinc in PDB 7crp: NSD3 Bearing E1181K/T1232A Dual Mutation in Complex with 187-Bp Ncp (1:1 Binding Mode)

Zinc Binding Sites:

The binding sites of Zinc atom in the NSD3 Bearing E1181K/T1232A Dual Mutation in Complex with 187-Bp Ncp (1:1 Binding Mode) (pdb code 7crp). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the NSD3 Bearing E1181K/T1232A Dual Mutation in Complex with 187-Bp Ncp (1:1 Binding Mode), PDB code: 7crp:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in 7crp

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Zinc binding site 1 out of 3 in the NSD3 Bearing E1181K/T1232A Dual Mutation in Complex with 187-Bp Ncp (1:1 Binding Mode)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of NSD3 Bearing E1181K/T1232A Dual Mutation in Complex with 187-Bp Ncp (1:1 Binding Mode) within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Zn1502

b:0.8
occ:1.00
SG I:CYS1273 2.3 94.8 1.0
SG I:CYS1275 2.5 82.7 1.0
CB I:CYS1280 2.7 81.0 1.0
SG I:CYS1226 3.0 79.8 1.0
O I:CYS1280 3.1 81.0 1.0
CA I:CYS1280 3.4 81.0 1.0
N I:CYS1226 3.4 79.8 1.0
CB I:CYS1226 3.6 79.8 1.0
CB I:CYS1273 3.6 94.8 1.0
SG I:CYS1280 3.6 81.0 1.0
C I:CYS1280 3.7 81.0 1.0
CB I:CYS1275 3.8 82.7 1.0
CA I:CYS1226 4.1 79.8 1.0
CA I:SER1225 4.3 78.5 1.0
C I:SER1225 4.3 78.5 1.0
O I:CYS1273 4.7 94.8 1.0
N I:CYS1280 4.7 81.0 1.0
NE2 I:HIS1224 4.8 85.0 1.0
N I:GLY1276 4.8 70.5 1.0
CA I:CYS1273 4.8 94.8 1.0
CA I:CYS1275 4.9 82.7 1.0
N I:CYS1275 5.0 82.7 1.0
C I:CYS1273 5.0 94.8 1.0

Zinc binding site 2 out of 3 in 7crp

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Zinc binding site 2 out of 3 in the NSD3 Bearing E1181K/T1232A Dual Mutation in Complex with 187-Bp Ncp (1:1 Binding Mode)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of NSD3 Bearing E1181K/T1232A Dual Mutation in Complex with 187-Bp Ncp (1:1 Binding Mode) within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Zn1503

b:87.2
occ:1.00
SG I:CYS1098 2.4 57.9 1.0
SG I:CYS1114 2.4 50.2 1.0
SG I:CYS1108 2.7 57.7 1.0
SG I:CYS1100 3.0 63.2 1.0
CB I:CYS1098 3.3 57.9 1.0
CB I:CYS1114 3.7 50.2 1.0
CB I:CYS1108 3.9 57.7 1.0
ZN I:ZN1504 4.0 74.0 1.0
CB I:CYS1100 4.0 63.2 1.0
CA I:CYS1108 4.3 57.7 1.0
CA I:CYS1114 4.3 50.2 1.0
N I:CYS1108 4.6 57.7 1.0
N I:CYS1100 4.7 63.2 1.0
SG I:CYS1128 4.7 61.0 1.0
CA I:CYS1098 4.8 57.9 1.0
N I:ASN1099 4.9 61.0 1.0
N I:LEU1115 5.0 36.9 1.0

Zinc binding site 3 out of 3 in 7crp

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Zinc binding site 3 out of 3 in the NSD3 Bearing E1181K/T1232A Dual Mutation in Complex with 187-Bp Ncp (1:1 Binding Mode)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of NSD3 Bearing E1181K/T1232A Dual Mutation in Complex with 187-Bp Ncp (1:1 Binding Mode) within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Zn1504

b:74.0
occ:1.00
SG I:CYS1128 2.4 61.0 1.0
SG I:CYS1108 2.4 57.7 1.0
SG I:CYS1134 3.1 71.0 1.0
CB I:CYS1134 3.2 71.0 1.0
CB I:CYS1123 3.4 56.7 1.0
SG I:CYS1123 3.4 56.7 1.0
CB I:CYS1108 3.5 57.7 1.0
CB I:CYS1128 3.6 61.0 1.0
CB I:ASN1136 3.9 57.8 1.0
ZN I:ZN1503 4.0 87.2 1.0
CA I:CYS1134 4.6 71.0 1.0
CB I:ALA1130 4.7 62.9 1.0
ND2 I:ASN1136 4.8 57.8 1.0
N I:ASN1136 4.8 57.8 1.0
CA I:CYS1123 4.8 56.7 1.0
CG I:ASN1136 4.9 57.8 1.0
CA I:CYS1128 4.9 61.0 1.0
CA I:CYS1108 4.9 57.7 1.0
CA I:ASN1136 5.0 57.8 1.0
C I:CYS1134 5.0 71.0 1.0

Reference:

W.Li, W.Tian, G.Yuan, P.Deng, O.Gozani, D.Patel, Z.Wang. Molecular Basis of Nucleosomal H3K36 Methylation By Nsd Methyltransferases To Be Published.
Page generated: Wed Dec 16 13:42:13 2020

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