Zinc in PDB 7cro: NSD2 Bearing E1099K/T1150A Dual Mutation in Complex with 187-Bp Ncp

All present enzymatic activity of NSD2 Bearing E1099K/T1150A Dual Mutation in Complex with 187-Bp Ncp:
2.1.1.356;

The binding sites of Zinc atom in the NSD2 Bearing E1099K/T1150A Dual Mutation in Complex with 187-Bp Ncp (pdb code 7cro). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the NSD2 Bearing E1099K/T1150A Dual Mutation in Complex with 187-Bp Ncp, PDB code: 7cro:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the NSD2 Bearing E1099K/T1150A Dual Mutation in Complex with 187-Bp Ncp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of NSD2 Bearing E1099K/T1150A Dual Mutation in Complex with 187-Bp Ncp within 5.0Å range: probe atom residue distance (Å) B Occ I:Zn1402 b:0.5 occ:1.00 SG I:CYS1026 2.3 85.9 1.0 SG I:CYS1032 2.3 68.5 1.0 SG I:CYS1018 2.4 91.2 1.0 SG I:CYS1016 2.5 74.4 1.0 CB I:CYS1026 2.9 85.9 1.0 CB I:CYS1032 3.1 68.5 1.0 CB I:CYS1018 3.2 91.2 1.0 CA I:CYS1026 3.3 85.9 1.0 CA I:CYS1032 3.8 68.5 1.0 CB I:CYS1016 4.0 74.4 1.0 N I:CYS1026 4.1 85.9 1.0 N I:CYS1018 4.2 91.2 1.0 CA I:CYS1018 4.3 91.2 1.0 C I:CYS1026 4.4 85.9 1.0 O I:GLU1031 4.6 77.6 1.0 C I:CYS1032 4.7 68.5 1.0 O I:CYS1026 4.8 85.9 1.0 N I:LEU1033 4.9 60.6 1.0 N I:ASN1017 4.9 80.9 1.0 N I:CYS1032 5.0 68.5 1.0

Zinc binding site 2 out of 3 in the NSD2 Bearing E1099K/T1150A Dual Mutation in Complex with 187-Bp Ncp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of NSD2 Bearing E1099K/T1150A Dual Mutation in Complex with 187-Bp Ncp within 5.0Å range: probe atom residue distance (Å) B Occ I:Zn1403 b:96.1 occ:1.00 SG I:CYS1041 2.4 88.7 1.0 SG I:CYS1052 2.5 84.7 1.0 CB I:CYS1041 2.7 88.7 1.0 CB I:CYS1052 3.1 84.7 1.0 SG I:CYS1046 3.2 91.7 1.0 CB I:CYS1046 3.3 91.7 1.0 SG I:CYS1026 3.8 85.9 1.0 CA I:CYS1041 4.2 88.7 1.0 CB I:CYS1026 4.3 85.9 1.0 CA I:CYS1046 4.3 91.7 1.0 CA I:CYS1052 4.5 84.7 1.0 CB I:CYS1016 4.6 74.4 1.0 O I:HIS1042 4.8 98.3 1.0 OD1 I:ASN1034 4.9 64.1 1.0 N I:CYS1046 4.9 91.7 1.0 C I:CYS1041 5.0 88.7 1.0

Zinc binding site 3 out of 3 in the NSD2 Bearing E1099K/T1150A Dual Mutation in Complex with 187-Bp Ncp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of NSD2 Bearing E1099K/T1150A Dual Mutation in Complex with 187-Bp Ncp within 5.0Å range: probe atom residue distance (Å) B Occ I:Zn1404 b:0.4 occ:1.00 O I:CYS1198 2.1 0.5 1.0 CB I:CYS1198 2.5 0.5 1.0 SG I:CYS1191 2.5 0.3 1.0 SG I:CYS1193 2.6 0.6 1.0 SG I:CYS1198 2.9 0.5 1.0 N I:CYS1193 2.9 0.6 1.0 C I:CYS1198 3.0 0.5 1.0 CB I:CYS1193 3.1 0.6 1.0 CA I:CYS1198 3.2 0.5 1.0 SG I:CYS1144 3.4 87.2 1.0 O I:CYS1191 3.4 0.3 1.0 C I:CYS1191 3.4 0.3 1.0 N I:ARG1192 3.5 0.2 1.0 C I:ARG1192 3.6 0.2 1.0 CA I:CYS1193 3.6 0.6 1.0 CA I:ARG1192 3.7 0.2 1.0 CB I:CYS1191 3.8 0.3 1.0 CB I:CYS1144 4.2 87.2 1.0 CA I:CYS1191 4.2 0.3 1.0 N I:SER1199 4.2 0.5 1.0 O I:SER1199 4.5 0.5 1.0 O I:ARG1192 4.5 0.2 1.0 N I:CYS1198 4.6 0.5 1.0 N I:GLY1194 4.6 93.3 1.0 C I:CYS1193 4.7 0.6 1.0 C I:SER1199 4.8 0.5 1.0 CA I:SER1199 4.8 0.5 1.0 N6 I:SAM1401 4.9 0.5 0.9

W.Li, W.Tian, G.Yuan, P.Deng, O.Gozani, D.Patel, Z.Wang. Molecular Basis of Nucleosomal H3K36 Methylation By Nsd Methyltransferases To Be Published.