Zinc in PDB 7cq4: Crystal Structure of SLX1-SLX4 in Complex with 5'Flap Dna

The structure of Crystal Structure of SLX1-SLX4 in Complex with 5'Flap Dna, PDB code: 7cq4 was solved by X.Xu, M.Wang, J.Sun, G.Li, N.Yang, R.M.Xu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.31 / 3.29
Space group	P 65 2 2
Cell size a, b, c (Å), α, β, γ (°)	123.223, 123.223, 233.576, 90, 90, 120
R / Rfree (%)	23.5 / 26.7

The binding sites of Zinc atom in the Crystal Structure of SLX1-SLX4 in Complex with 5'Flap Dna (pdb code 7cq4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of SLX1-SLX4 in Complex with 5'Flap Dna, PDB code: 7cq4:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of SLX1-SLX4 in Complex with 5'Flap Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of SLX1-SLX4 in Complex with 5'Flap Dna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:107.6 occ:1.00 ND1 A:HIS251 2.2 95.8 1.0 SG A:CYS221 2.3 119.5 1.0 SG A:CYS218 2.4 99.3 1.0 SG A:CYS254 2.4 113.8 1.0 CG A:HIS251 2.6 103.3 1.0 CB A:CYS218 2.9 110.9 1.0 CB A:HIS251 3.0 104.6 1.0 CE1 A:HIS251 3.0 100.7 1.0 CB A:CYS221 3.5 112.5 1.0 CD2 A:HIS251 3.6 104.6 1.0 CB A:CYS254 3.6 103.0 1.0 NE2 A:HIS251 3.7 97.6 1.0 N A:HIS251 3.9 105.9 1.0 CA A:HIS251 4.0 102.2 1.0 N A:CYS221 4.2 107.3 1.0 CA A:CYS221 4.4 112.5 1.0 CA A:CYS218 4.5 111.9 1.0 CA A:CYS254 4.9 97.9 1.0 C A:HIS251 5.0 102.7 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of SLX1-SLX4 in Complex with 5'Flap Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of SLX1-SLX4 in Complex with 5'Flap Dna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn402 b:134.1 occ:1.00 SG A:CYS282 2.3 109.2 1.0 SG A:CYS246 2.3 136.9 1.0 SG A:CYS279 2.3 130.9 1.0 SG A:CYS241 2.4 134.8 1.0 CB A:CYS241 3.0 122.5 1.0 CB A:CYS282 3.0 124.4 1.0 CB A:CYS246 3.1 137.7 1.0 CB A:CYS279 3.2 123.0 1.0 N A:CYS282 3.4 124.2 1.0 SG A:CYS248 3.6 112.2 1.0 CA A:CYS282 3.8 122.7 1.0 CB A:LYS281 4.2 130.6 1.0 CA A:CYS241 4.4 118.2 1.0 C A:LYS281 4.5 125.8 1.0 CA A:CYS246 4.5 140.8 1.0 C A:CYS282 4.6 124.3 1.0 CA A:CYS279 4.6 116.9 1.0 CB A:CYS248 4.6 119.8 1.0 CA A:LYS281 4.7 131.4 1.0 N A:LYS281 4.8 133.3 1.0 N A:CYS248 4.8 122.3 1.0 N A:GLY247 4.8 137.4 1.0 N A:ASP283 4.8 125.8 1.0 C A:CYS246 4.9 137.9 1.0 CB A:ASN243 5.0 140.0 1.0 CG A:LYS281 5.0 133.3 1.0

X.Xu, M.Wang, J.Sun, G.Li, N.Yang, R.M.Xu. Structural Insights Into Substrate Dna Recognition By the SLX1-SLX4 Endonuclease Complex To Be Published.