Zinc in PDB 7cq2: Crystal Structure of SLX1-SLX4

The structure of Crystal Structure of SLX1-SLX4, PDB code: 7cq2 was solved by X.Xu, M.Wang, J.Sun, G.Li, N.Yang, R.M.Xu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.49 / 2.50
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	61.284, 75.96, 186.966, 90, 90, 90
R / Rfree (%)	20.1 / 26.2

The binding sites of Zinc atom in the Crystal Structure of SLX1-SLX4 (pdb code 7cq2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of SLX1-SLX4, PDB code: 7cq2:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Crystal Structure of SLX1-SLX4


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of SLX1-SLX4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:45.1 occ:1.00 ND1 A:HIS251 2.1 41.9 1.0 SG A:CYS254 2.3 43.1 1.0 SG A:CYS221 2.3 44.1 1.0 SG A:CYS218 2.3 42.9 1.0 CG A:HIS251 3.0 43.2 1.0 CE1 A:HIS251 3.1 43.7 1.0 CB A:CYS218 3.1 45.1 1.0 CB A:HIS251 3.3 40.0 1.0 CB A:CYS221 3.3 50.4 1.0 CB A:CYS254 3.4 42.5 1.0 O A:HOH552 3.8 45.6 1.0 N A:CYS221 3.9 48.5 1.0 N A:HIS251 4.0 40.6 1.0 CA A:CYS221 4.2 49.2 1.0 CD2 A:HIS251 4.2 43.4 1.0 NE2 A:HIS251 4.2 44.8 1.0 CA A:HIS251 4.3 41.1 1.0 CA A:CYS218 4.6 46.2 1.0 CA A:CYS254 4.7 39.6 1.0 CB A:ILE220 4.8 45.8 1.0 C A:CYS221 4.9 52.2 1.0 N A:CYS254 5.0 38.7 1.0 C A:ILE220 5.0 49.2 1.0

Zinc binding site 2 out of 4 in the Crystal Structure of SLX1-SLX4


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of SLX1-SLX4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn402 b:46.9 occ:1.00 SG A:CYS241 2.3 43.4 1.0 SG A:CYS282 2.3 42.9 1.0 SG A:CYS246 2.3 48.8 1.0 SG A:CYS279 2.4 43.1 1.0 CB A:CYS246 3.0 49.5 1.0 CB A:CYS279 3.1 42.2 1.0 CB A:CYS282 3.2 44.1 1.0 CB A:CYS241 3.4 43.8 1.0 N A:CYS282 3.7 46.7 1.0 CA A:CYS282 4.0 47.5 1.0 SG A:CYS248 4.3 49.5 1.0 CB A:ASN243 4.4 50.9 1.0 CA A:CYS246 4.5 52.0 1.0 CA A:CYS279 4.6 44.0 1.0 CB A:LYS281 4.7 48.4 1.0 O A:HOH558 4.7 38.4 1.0 C A:CYS282 4.7 47.0 1.0 C A:LYS281 4.8 46.6 1.0 CA A:CYS241 4.8 43.9 1.0 N A:GLY247 4.8 51.7 1.0 ND2 A:ASN243 4.8 50.2 1.0 C A:CYS246 4.9 51.8 1.0 N A:ASP283 4.9 44.9 1.0 N A:LYS281 5.0 45.1 1.0

Zinc binding site 3 out of 4 in the Crystal Structure of SLX1-SLX4


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of SLX1-SLX4 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn401 b:71.5 occ:1.00 ND1 B:HIS251 2.1 69.8 1.0 SG B:CYS254 2.3 70.2 1.0 SG B:CYS221 2.3 78.1 1.0 SG B:CYS218 2.3 73.5 1.0 CG B:HIS251 3.0 69.8 1.0 CE1 B:HIS251 3.1 75.0 1.0 CB B:CYS218 3.1 75.4 1.0 CB B:HIS251 3.3 65.4 1.0 CB B:CYS254 3.5 64.0 1.0 CB B:CYS221 3.7 77.8 1.0 N B:HIS251 4.0 65.6 1.0 N B:CYS221 4.0 80.3 1.0 NE2 B:HIS251 4.1 74.1 1.0 CD2 B:HIS251 4.1 71.5 1.0 CA B:HIS251 4.3 64.6 1.0 CA B:CYS221 4.4 80.7 1.0 CA B:CYS218 4.6 76.2 1.0 CB B:ILE220 4.8 75.9 1.0 CA B:CYS254 4.8 59.5 1.0 C B:ILE220 5.0 79.7 1.0

Zinc binding site 4 out of 4 in the Crystal Structure of SLX1-SLX4


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of SLX1-SLX4 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn402 b:72.9 occ:1.00 SG B:CYS282 2.3 69.3 1.0 SG B:CYS241 2.3 60.5 1.0 SG B:CYS279 2.3 77.9 1.0 SG B:CYS246 2.3 69.1 1.0 CB B:CYS282 3.1 70.4 1.0 CB B:CYS279 3.1 70.2 1.0 CB B:CYS241 3.2 64.3 1.0 CB B:CYS246 3.3 73.3 1.0 N B:CYS282 3.7 73.0 1.0 CA B:CYS282 4.0 70.5 1.0 SG B:CYS248 4.2 71.6 1.0 CB B:ASN243 4.4 70.7 1.0 CA B:CYS279 4.6 69.2 1.0 CA B:CYS241 4.7 64.0 1.0 C B:CYS282 4.7 71.2 1.0 CA B:CYS246 4.7 75.4 1.0 N B:GLY247 4.7 70.7 1.0 C B:LYS281 4.8 75.0 1.0 CB B:LYS281 4.8 75.9 1.0 N B:ASP283 4.8 70.3 1.0 ND2 B:ASN243 4.9 71.4 1.0

X.Xu, M.Wang, J.Sun, G.Li, N.Yang, R.M.Xu. Structural Insights Into Substrate Dna Recognition By the SLX1-SLX4 Endonuclease Complex To Be Published.