Zinc in PDB 7aoh: Atomic Structure of the Poxvirus Late Initially Transcribing Complex

All present enzymatic activity of Atomic Structure of the Poxvirus Late Initially Transcribing Complex:
2.7.7.6; 3.6.1.15;

The structure of Atomic Structure of the Poxvirus Late Initially Transcribing Complex also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Zinc atom in the Atomic Structure of the Poxvirus Late Initially Transcribing Complex (pdb code 7aoh). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Atomic Structure of the Poxvirus Late Initially Transcribing Complex, PDB code: 7aoh:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Atomic Structure of the Poxvirus Late Initially Transcribing Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Atomic Structure of the Poxvirus Late Initially Transcribing Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1302 b:72.8 occ:1.00 NE2 A:HIS62 2.1 53.9 1.0 SG A:CYS52 2.3 57.8 1.0 SG A:CYS59 2.3 57.1 1.0 SG A:CYS49 2.3 62.5 1.0 CD2 A:HIS62 2.9 53.9 1.0 CB A:CYS49 2.9 62.5 1.0 CE1 A:HIS62 3.1 53.9 1.0 CB A:CYS59 3.5 57.1 1.0 CB A:CYS52 3.6 57.8 1.0 N A:CYS52 3.9 57.8 1.0 CG A:HIS62 4.1 53.9 1.0 ND1 A:HIS62 4.2 53.9 1.0 CA A:GLY42 4.3 58.9 1.0 CA A:CYS52 4.3 57.8 1.0 CA A:CYS59 4.4 57.1 1.0 CA A:CYS49 4.4 62.5 1.0 CB A:THR51 4.5 58.8 1.0 N A:ALA43 4.5 61.7 1.0 N A:GLY61 4.6 54.4 1.0 C A:GLY42 4.8 58.9 1.0 CA A:GLY61 4.8 54.4 1.0 C A:THR51 4.9 58.8 1.0 N A:GLY42 4.9 58.9 1.0 C A:CYS52 5.0 57.8 1.0 N A:THR51 5.0 58.8 1.0

Zinc binding site 2 out of 4 in the Atomic Structure of the Poxvirus Late Initially Transcribing Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Atomic Structure of the Poxvirus Late Initially Transcribing Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1303 b:108.1 occ:1.00 SG A:CYS93 2.3 91.8 1.0 SG A:CYS90 2.3 89.6 1.0 SG A:CYS130 2.3 96.5 1.0 CB A:CYS90 2.8 89.6 1.0 CB A:CYS130 3.1 96.5 1.0 CB A:CYS93 3.6 91.8 1.0 N A:CYS93 3.7 91.8 1.0 CA A:CYS93 4.2 91.8 1.0 CA A:CYS90 4.3 89.6 1.0 CB A:HIS92 4.3 94.1 1.0 CA A:CYS130 4.4 96.5 1.0 CB A:CYS135 4.4 101.1 1.0 C A:HIS92 4.5 94.1 1.0 O A:CYS135 4.5 101.1 1.0 N A:HIS92 4.7 94.1 1.0 O A:CYS93 4.7 91.8 1.0 CA A:HIS92 4.7 94.1 1.0 C A:CYS90 4.8 89.6 1.0 C A:CYS93 4.8 91.8 1.0

Zinc binding site 3 out of 4 in the Atomic Structure of the Poxvirus Late Initially Transcribing Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Atomic Structure of the Poxvirus Late Initially Transcribing Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1201 b:67.3 occ:1.00 SG B:CYS1103 2.3 50.5 1.0 SG B:CYS1090 2.3 50.6 1.0 SG B:CYS1087 2.3 48.1 1.0 SG B:CYS1106 2.3 52.1 1.0 CB B:CYS1087 3.2 48.1 1.0 CB B:CYS1106 3.3 52.1 1.0 CB B:CYS1103 3.5 50.5 1.0 CB B:CYS1090 3.6 50.6 1.0 N B:CYS1090 3.7 50.6 1.0 N B:CYS1106 4.0 52.1 1.0 OD1 B:ASP1092 4.0 49.1 1.0 CA B:CYS1090 4.2 50.6 1.0 CA B:CYS1106 4.3 52.1 1.0 CB B:ASN1089 4.3 50.9 1.0 CG B:PRO1113 4.4 51.8 1.0 CA B:CYS1087 4.6 48.1 1.0 ND2 B:ASN1089 4.7 50.9 1.0 C B:ASN1089 4.8 50.9 1.0 CB B:ARG1105 4.8 51.9 1.0 CB B:PRO1113 4.8 51.8 1.0 N B:GLY1091 4.8 47.7 1.0 CA B:CYS1103 4.9 50.5 1.0 N B:ASN1089 4.9 50.9 1.0 CA B:ASN1089 4.9 50.9 1.0 CG B:ASP1092 5.0 49.1 1.0 C B:CYS1090 5.0 50.6 1.0

Zinc binding site 4 out of 4 in the Atomic Structure of the Poxvirus Late Initially Transcribing Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Atomic Structure of the Poxvirus Late Initially Transcribing Complex within 5.0Å range: probe atom residue distance (Å) B Occ J:Zn101 b:63.3 occ:1.00 SG J:CYS10 2.3 42.5 1.0 SG J:CYS40 2.3 44.1 1.0 SG J:CYS7 2.3 41.6 1.0 SG J:CYS39 2.3 43.4 1.0 CB J:CYS7 3.1 41.6 1.0 N J:CYS40 3.3 44.1 1.0 CB J:CYS10 3.5 42.5 1.0 CB J:CYS39 3.5 43.4 1.0 CB J:CYS40 3.6 44.1 1.0 CA J:CYS40 3.8 44.1 1.0 N J:CYS10 3.9 42.5 1.0 C J:CYS39 3.9 43.4 1.0 CA J:CYS10 4.3 42.5 1.0 CA J:CYS39 4.3 43.4 1.0 CB J:ASN37 4.3 46.8 1.0 ND2 J:ASN37 4.4 46.8 1.0 CA J:CYS7 4.5 41.6 1.0 CB J:THR9 4.6 40.5 1.0 O J:CYS39 4.7 43.4 1.0 C J:THR9 4.8 40.5 1.0 N J:CYS39 4.9 43.4 1.0 N J:GLY11 4.9 42.2 1.0 CG J:ASN37 4.9 46.8 1.0 C J:CYS10 4.9 42.5 1.0 C J:CYS7 4.9 41.6 1.0 N J:THR9 5.0 40.5 1.0 CB J:LYS12 5.0 45.6 1.0

C.Grimm, J.Bartuli, B.Boettcher, A.A.Szalay, U.Fischer. Structural Basis of the Complete Poxvirus Transcription Initiation Process Nat.Struct.Mol.Biol. 2021.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-021-00655-W