Zinc in PDB 6yz1: The Crystal Structure of Sars-Cov-2 NSP10-NSP16 Methyltransferase Complex with Sinefungin

All present enzymatic activity of The Crystal Structure of Sars-Cov-2 NSP10-NSP16 Methyltransferase Complex with Sinefungin:
2.7.7.48; 3.4.19.12; 3.4.22.69; 3.6.4.12; 3.6.4.13;

The structure of The Crystal Structure of Sars-Cov-2 NSP10-NSP16 Methyltransferase Complex with Sinefungin, PDB code: 6yz1 was solved by P.Krafcikova, J.Silhan, R.Nencka, E.Boura, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.64 / 2.40
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	168.490, 168.490, 52.100, 90.00, 90.00, 120.00
R / Rfree (%)	18.7 / 22.6

The binding sites of Zinc atom in the The Crystal Structure of Sars-Cov-2 NSP10-NSP16 Methyltransferase Complex with Sinefungin (pdb code 6yz1). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the The Crystal Structure of Sars-Cov-2 NSP10-NSP16 Methyltransferase Complex with Sinefungin, PDB code: 6yz1:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the The Crystal Structure of Sars-Cov-2 NSP10-NSP16 Methyltransferase Complex with Sinefungin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Crystal Structure of Sars-Cov-2 NSP10-NSP16 Methyltransferase Complex with Sinefungin within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn201 b:41.2 occ:1.00 NE2 B:HIS83 2.0 54.5 1.0 SG B:CYS74 2.3 39.7 1.0 SG B:CYS90 2.3 37.1 1.0 SG B:CYS77 2.3 32.1 1.0 CE1 B:HIS83 2.9 37.4 1.0 CB B:CYS74 3.1 36.0 1.0 CD2 B:HIS83 3.1 43.0 1.0 CB B:CYS90 3.3 45.8 1.0 CB B:CYS77 3.4 28.7 1.0 N B:CYS77 3.5 34.3 1.0 CA B:CYS77 4.0 34.8 1.0 ND1 B:HIS83 4.0 49.2 1.0 CG B:HIS83 4.2 54.1 1.0 CA B:CYS90 4.4 49.0 1.0 CB B:TYR76 4.5 40.0 1.0 CA B:CYS74 4.5 36.2 1.0 C B:TYR76 4.5 37.0 1.0 O B:CYS74 4.8 39.5 1.0 C B:CYS74 4.8 34.0 1.0 CA B:TYR76 4.9 35.5 1.0 CB B:LYS93 4.9 31.0 1.0 N B:TYR76 4.9 30.0 1.0

Zinc binding site 2 out of 2 in the The Crystal Structure of Sars-Cov-2 NSP10-NSP16 Methyltransferase Complex with Sinefungin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of The Crystal Structure of Sars-Cov-2 NSP10-NSP16 Methyltransferase Complex with Sinefungin within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn202 b:73.4 occ:1.00 SG B:CYS130 2.3 86.9 1.0 SG B:CYS128 2.3 66.3 1.0 SG B:CYS117 2.3 67.8 1.0 SG B:CYS120 2.3 59.9 1.0 CB B:CYS117 3.0 63.1 1.0 CB B:CYS130 3.2 81.7 1.0 CB B:CYS120 3.5 55.9 1.0 CB B:CYS128 3.6 66.1 1.0 CG2 B:VAL119 3.8 74.4 1.0 N B:CYS120 4.0 62.4 1.0 N B:CYS130 4.1 87.4 1.0 CA B:CYS128 4.2 75.8 1.0 CA B:CYS130 4.3 75.5 1.0 CA B:CYS120 4.3 62.9 1.0 CE B:LYS124 4.4 86.6 1.0 CA B:CYS117 4.5 53.0 1.0 NZ B:LYS124 4.5 74.5 1.0 N B:SER129 4.6 70.7 1.0 C B:CYS128 4.7 74.5 1.0 N B:GLY121 5.0 56.1 1.0 C B:CYS120 5.0 59.7 1.0

P.Krafcikova, J.Silhan, R.Nencka, E.Boura. The Crystal Structure of Sars-Cov-2 NSP10-NSP16 Methyltransferase Complex with Sinefungin To Be Published.