Zinc in PDB 6yyt: Structure of Replicating Sars-Cov-2 Polymerase

All present enzymatic activity of Structure of Replicating Sars-Cov-2 Polymerase:
2.7.7.48; 3.4.19.12; 3.4.22.69; 3.6.4.12; 3.6.4.13;

The binding sites of Zinc atom in the Structure of Replicating Sars-Cov-2 Polymerase (pdb code 6yyt). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Replicating Sars-Cov-2 Polymerase, PDB code: 6yyt:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Replicating Sars-Cov-2 Polymerase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Replicating Sars-Cov-2 Polymerase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2000 b:60.6 occ:1.00 ND1 A:HIS295 2.1 25.3 1.0 SG A:CYS310 2.3 24.4 1.0 SG A:CYS301 2.3 26.0 1.0 SG A:CYS306 2.3 25.4 1.0 CE1 A:HIS295 2.9 25.3 1.0 CG A:HIS295 3.2 25.3 1.0 O A:CYS306 3.3 25.4 1.0 CB A:CYS301 3.3 26.0 1.0 CB A:CYS306 3.5 25.4 1.0 CA A:CYS301 3.6 26.0 1.0 CB A:HIS295 3.6 25.3 1.0 C A:CYS306 3.7 25.4 1.0 CB A:CYS310 3.9 24.4 1.0 NE2 A:HIS295 4.0 25.3 1.0 CA A:CYS306 4.1 25.4 1.0 O A:ASN300 4.2 24.9 1.0 CD2 A:HIS295 4.2 25.3 1.0 N A:HIS295 4.4 25.3 1.0 N A:ILE307 4.4 23.9 1.0 N A:CYS301 4.5 26.0 1.0 CA A:HIS295 4.6 25.3 1.0 N A:LEU302 4.7 25.8 1.0 C A:ASN300 4.7 24.9 1.0 C A:CYS301 4.7 26.0 1.0 CA A:ILE307 4.9 23.9 1.0 O A:THR293 4.9 25.1 1.0 N A:CYS310 4.9 24.4 1.0 CA A:CYS310 5.0 24.4 1.0

Zinc binding site 2 out of 2 in the Structure of Replicating Sars-Cov-2 Polymerase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Replicating Sars-Cov-2 Polymerase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2001 b:47.1 occ:1.00 SG A:CYS646 2.3 24.9 1.0 SG A:CYS645 2.3 27.4 1.0 SG A:CYS487 2.3 21.8 1.0 ND1 A:HIS642 2.3 22.2 1.0 CG A:HIS642 3.1 22.2 1.0 CB A:CYS645 3.2 27.4 1.0 CB A:HIS642 3.2 22.2 1.0 N A:CYS646 3.4 24.9 1.0 CE1 A:HIS642 3.4 22.2 1.0 CB A:CYS646 3.4 24.9 1.0 CB A:CYS487 3.4 21.8 1.0 C A:CYS645 3.7 27.4 1.0 CA A:CYS646 3.9 24.9 1.0 N A:CYS487 3.9 21.8 1.0 CA A:CYS645 4.0 27.4 1.0 CA A:HIS642 4.1 22.2 1.0 CA A:CYS487 4.2 21.8 1.0 CD2 A:HIS642 4.3 22.2 1.0 C A:GLY486 4.4 21.0 1.0 NE2 A:HIS642 4.4 22.2 1.0 O A:CYS645 4.5 27.4 1.0 CE1 A:PHE571 4.5 21.4 1.0 N A:CYS645 4.6 27.4 1.0 CA A:GLY486 4.7 21.0 1.0 C A:HIS642 5.0 22.2 1.0

H.S.Hillen, G.Kokic, L.Farnung, C.Dienemann, D.Tegunov, P.Cramer. Structure of Replication Sars-Cov-2 Polymerase To Be Published.