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Zinc in PDB 6yh2: Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One

Enzymatic activity of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One

All present enzymatic activity of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One:
2.4.2.29;

Protein crystallography data

The structure of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One, PDB code: 6yh2 was solved by A.Nguyen, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.10 / 1.19
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 90.724, 65.338, 70.909, 90.00, 96.13, 90.00
R / Rfree (%) 11.9 / 13.5

Other elements in 6yh2:

The structure of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One also contains other interesting chemical elements:

Fluorine (F) 4 atoms
Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One (pdb code 6yh2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One, PDB code: 6yh2:

Zinc binding site 1 out of 1 in 6yh2

Go back to Zinc Binding Sites List in 6yh2
Zinc binding site 1 out of 1 in the Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:12.9
occ:1.00
 ND1 A:HIS349 2.1 12.2 1.0
SG A:CYS320 2.3 12.3 1.0
SG A:CYS323 2.3 13.0 1.0
SG A:CYS318 2.3 15.0 1.0
CE1 A:HIS349 2.9 13.2 1.0
HE1 A:HIS349 3.0 15.9 1.0
HB2 A:CYS323 3.0 15.0 1.0
HB3 A:CYS318 3.1 18.5 1.0
HB3 A:CYS320 3.2 15.5 1.0
CG A:HIS349 3.2 11.4 1.0
CB A:CYS323 3.3 12.5 1.0
CB A:CYS318 3.3 15.4 1.0
H A:CYS323 3.3 15.0 1.0
HB2 A:HIS349 3.3 13.0 1.0
CB A:CYS320 3.4 12.9 1.0
H A:CYS320 3.5 19.4 1.0
HA A:HIS349 3.5 13.4 1.0
CB A:HIS349 3.7 10.8 1.0
HB2 A:CYS318 3.7 18.5 1.0
HB A:VAL322 3.8 14.0 1.0
N A:CYS323 3.9 12.5 1.0
HB3 A:CYS323 4.0 15.0 1.0
CA A:HIS349 4.1 11.2 1.0
HB2 A:CYS320 4.1 15.5 1.0
NE2 A:HIS349 4.1 13.6 1.0
N A:CYS320 4.1 16.2 1.0
CA A:CYS323 4.2 12.3 1.0
HB2 A:LEU314 4.2 16.0 1.0
CA A:CYS320 4.2 14.0 1.0
CD2 A:HIS349 4.3 12.5 1.0
HB3 A:ALA352 4.4 15.4 1.0
HE22 A:GLN356 4.5 25.9 1.0
HB3 A:ASP315 4.5 20.3 1.0
HD12 A:LEU314 4.5 15.5 1.0
HB3 A:HIS349 4.6 13.0 1.0
O A:HIS349 4.6 11.6 1.0
HA A:CYS323 4.6 14.8 1.0
CA A:CYS318 4.6 16.9 1.0
H A:ASP315 4.6 18.3 1.0
O A:CYS320 4.7 13.8 1.0
C A:CYS320 4.7 13.0 1.0
C A:CYS318 4.7 18.8 1.0
H A:VAL322 4.7 14.9 1.0
CB A:VAL322 4.8 11.6 1.0
C A:HIS349 4.8 10.8 1.0
O A:CYS318 4.8 19.0 1.0
HE2 A:HIS349 4.9 16.3 1.0
C A:VAL322 4.9 12.2 1.0

Reference:

A.Nguyen, A.Heine, G.Klebe. Co-Crystallization, Nanoesi-Ms and 19F uc(Nmr) Reveal Dimer Disturbing Inhibitors and Conformational Changes at Dimer Contacts To Be Published.
Page generated: Tue Oct 29 11:32:52 2024

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