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Zinc in PDB 6ygx: Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-2-(Methylamino)-4-(2-((2R,3R,4S, 5R,6S)-3,4,5,6-Tetramethoxytetrahydro-2H-Pyran-2-Yl)Ethyl)-1H- Imidazo[4,5-G]Quinazolin-8(7H)-One
Enzymatic activity of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-2-(Methylamino)-4-(2-((2R,3R,4S, 5R,6S)-3,4,5,6-Tetramethoxytetrahydro-2H-Pyran-2-Yl)Ethyl)-1H- Imidazo[4,5-G]Quinazolin-8(7H)-One
All present enzymatic activity of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-2-(Methylamino)-4-(2-((2R,3R,4S, 5R,6S)-3,4,5,6-Tetramethoxytetrahydro-2H-Pyran-2-Yl)Ethyl)-1H- Imidazo[4,5-G]Quinazolin-8(7H)-One:
2.4.2.29;
2.4.2.29;
Protein crystallography data
The structure of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-2-(Methylamino)-4-(2-((2R,3R,4S, 5R,6S)-3,4,5,6-Tetramethoxytetrahydro-2H-Pyran-2-Yl)Ethyl)-1H- Imidazo[4,5-G]Quinazolin-8(7H)-One, PDB code: 6ygx
was solved by
A.Nguyen,
A.Heine,
G.Klebe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 42.60 / 1.35 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 85.083, 64.980, 71.374, 90.00, 93.78, 90.00 |
| R / Rfree (%) | 13.5 / 15.6 |
Other elements in 6ygx:
The structure of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-2-(Methylamino)-4-(2-((2R,3R,4S, 5R,6S)-3,4,5,6-Tetramethoxytetrahydro-2H-Pyran-2-Yl)Ethyl)-1H- Imidazo[4,5-G]Quinazolin-8(7H)-One also contains other interesting chemical elements:
| Fluorine | (F) | 4 atoms |
Zinc Binding Sites:
The binding sites of Zinc atom in the Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-2-(Methylamino)-4-(2-((2R,3R,4S, 5R,6S)-3,4,5,6-Tetramethoxytetrahydro-2H-Pyran-2-Yl)Ethyl)-1H- Imidazo[4,5-G]Quinazolin-8(7H)-One
(pdb code 6ygx). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-2-(Methylamino)-4-(2-((2R,3R,4S, 5R,6S)-3,4,5,6-Tetramethoxytetrahydro-2H-Pyran-2-Yl)Ethyl)-1H- Imidazo[4,5-G]Quinazolin-8(7H)-One, PDB code: 6ygx:
In total only one binding site of Zinc was determined in the Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-2-(Methylamino)-4-(2-((2R,3R,4S, 5R,6S)-3,4,5,6-Tetramethoxytetrahydro-2H-Pyran-2-Yl)Ethyl)-1H- Imidazo[4,5-G]Quinazolin-8(7H)-One, PDB code: 6ygx:
Zinc binding site 1 out of 1 in 6ygx
Go back to
Zinc Binding Sites List in 6ygx
Zinc binding site 1 out
of 1 in the Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-2-(Methylamino)-4-(2-((2R,3R,4S, 5R,6S)-3,4,5,6-Tetramethoxytetrahydro-2H-Pyran-2-Yl)Ethyl)-1H- Imidazo[4,5-G]Quinazolin-8(7H)-One
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-2-(Methylamino)-4-(2-((2R,3R,4S, 5R,6S)-3,4,5,6-Tetramethoxytetrahydro-2H-Pyran-2-Yl)Ethyl)-1H- Imidazo[4,5-G]Quinazolin-8(7H)-One within 5.0Å range:
|
Reference:
A.Nguyen,
A.Heine,
G.Klebe.
Co-Crystallization, Nanoesi-Ms and 19F uc(Nmr) Reveal Dimer Disturbing Inhibitors and Conformational Changes at Dimer Contacts To Be Published.
Page generated: Tue Oct 29 11:32:52 2024
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