Zinc in PDB 6x9i: Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna

All present enzymatic activity of Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna:
2.1.1.37;

The structure of Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna, PDB code: 6x9i was solved by S.Pathuri, J.R.Horton, X.Cheng, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.21 / 2.20
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	161.886, 77.698, 115.408, 90, 125.67, 90
R / Rfree (%)	19.4 / 22.5

The binding sites of Zinc atom in the Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna (pdb code 6x9i). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna, PDB code: 6x9i:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1702 b:89.8 occ:1.00 NE2 A:HIS1502 2.1 139.9 1.0 SG A:CYS1478 2.2 120.1 1.0 SG A:CYS1476 2.4 105.5 1.0 SG A:CYS1485 2.4 100.4 1.0 CD2 A:HIS1502 2.6 131.2 1.0 CB A:CYS1476 2.9 102.5 1.0 CB A:CYS1478 3.2 115.8 1.0 CE1 A:HIS1502 3.3 129.6 1.0 N A:CYS1478 3.5 113.6 1.0 CB A:CYS1485 3.5 112.6 1.0 CG A:HIS1502 3.8 121.8 1.0 CA A:CYS1478 3.9 111.2 1.0 CA A:CYS1485 4.0 119.5 1.0 N A:SER1477 4.0 121.7 1.0 ND1 A:HIS1502 4.1 125.1 1.0 CA A:CYS1476 4.1 108.6 1.0 C A:CYS1476 4.2 117.4 1.0 C A:SER1477 4.5 125.4 1.0 N A:CYS1485 4.7 119.5 1.0 CA A:SER1477 4.8 127.0 1.0 CZ2 A:TRP1498 4.8 93.8 1.0 O A:HIS1502 4.9 93.5 1.0 O A:CYS1476 5.0 122.1 1.0

Zinc binding site 2 out of 2 in the Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1703 b:78.2 occ:1.00 NE2 A:HIS793 2.1 118.3 1.0 SG A:CYS896 2.2 84.6 1.0 SG A:CYS820 2.3 72.7 1.0 SG A:CYS893 2.4 97.7 1.0 CE1 A:HIS793 3.0 113.3 1.0 CD2 A:HIS793 3.1 114.2 1.0 CB A:CYS820 3.2 70.2 1.0 CB A:CYS893 3.4 105.0 1.0 CB A:CYS896 3.6 84.9 1.0 N A:CYS896 3.6 87.9 1.0 CA A:CYS896 4.0 86.5 1.0 ND1 A:HIS793 4.1 114.1 1.0 CG A:HIS793 4.1 111.7 1.0 CB A:SER895 4.4 83.0 1.0 C A:SER895 4.5 82.8 1.0 CA A:CYS820 4.6 67.9 1.0 OG A:SER895 4.7 79.9 1.0 C A:CYS820 4.9 66.2 1.0 CA A:SER895 4.9 85.4 1.0 CA A:CYS893 4.9 105.9 1.0 N A:GLU821 5.0 68.5 1.0

S.Pathuri, J.R.Horton, X.Zhang, X.Cheng. Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna To Be Published.