Zinc in PDB 6w9n: Solution Structure of the Fyve Domain of Alfy

The binding sites of Zinc atom in the Solution Structure of the Fyve Domain of Alfy (pdb code 6w9n). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Solution Structure of the Fyve Domain of Alfy, PDB code: 6w9n:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Solution Structure of the Fyve Domain of Alfy


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Solution Structure of the Fyve Domain of Alfy within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn101 b:0.0 occ:1.00 SG A:CYS44 2.3 0.0 1.0 SG A:CYS23 2.3 0.0 1.0 SG A:CYS47 2.3 0.0 1.0 SG A:CYS20 2.3 0.0 1.0 HB2 A:CYS23 2.3 0.0 1.0 CB A:CYS23 2.8 0.0 1.0 HB2 A:CYS47 2.9 0.0 1.0 H A:CYS44 3.1 0.0 1.0 CB A:CYS47 3.2 0.0 1.0 HG12 A:VAL25 3.4 0.0 1.0 CB A:CYS20 3.6 0.0 1.0 HB3 A:CYS23 3.6 0.0 1.0 CB A:CYS44 3.7 0.0 1.0 N A:CYS23 3.7 0.0 1.0 HB3 A:CYS44 3.7 0.0 1.0 HB2 A:CYS20 3.7 0.0 1.0 HB3 A:CYS20 3.7 0.0 1.0 H A:CYS23 3.8 0.0 1.0 CA A:CYS23 3.8 0.0 1.0 N A:CYS44 3.9 0.0 1.0 C A:GLY22 4.0 0.0 1.0 H A:GLY22 4.0 0.0 1.0 HB3 A:CYS47 4.0 0.0 1.0 HA A:CYS47 4.1 0.0 1.0 CA A:CYS47 4.1 0.0 1.0 H A:CYS47 4.2 0.0 1.0 CG1 A:VAL25 4.3 0.0 1.0 N A:CYS47 4.3 0.0 1.0 HD1 A:PHE43 4.3 0.0 1.0 O A:GLY22 4.3 0.0 1.0 HA3 A:GLY22 4.4 0.0 1.0 HG13 A:VAL25 4.4 0.0 1.0 CA A:CYS44 4.4 0.0 1.0 HG11 A:VAL25 4.4 0.0 1.0 HB2 A:CYS44 4.5 0.0 1.0 HA A:CYS23 4.5 0.0 1.0 HA A:PHE43 4.5 0.0 1.0 HB3 A:PHE43 4.5 0.0 1.0 CA A:GLY22 4.5 0.0 1.0 H A:SER24 4.5 0.0 1.0 N A:GLY22 4.6 0.0 1.0 H A:VAL25 4.7 0.0 1.0 C A:CYS23 4.9 0.0 1.0 H A:SER21 4.9 0.0 1.0 HB3 A:LYS46 4.9 0.0 1.0 CA A:CYS20 4.9 0.0 1.0

Zinc binding site 2 out of 2 in the Solution Structure of the Fyve Domain of Alfy


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Solution Structure of the Fyve Domain of Alfy within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn102 b:0.0 occ:1.00 SG A:CYS66 2.4 0.0 1.0 SG A:CYS69 2.4 0.0 1.0 SG A:CYS39 2.4 0.0 1.0 SG A:CYS36 2.4 0.0 1.0 HB3 A:ASN38 2.6 0.0 1.0 HB2 A:CYS69 3.1 0.0 1.0 H A:CYS66 3.1 0.0 1.0 H A:CYS39 3.3 0.0 1.0 CB A:CYS69 3.4 0.0 1.0 CB A:ASN38 3.7 0.0 1.0 HB2 A:CYS39 3.7 0.0 1.0 CB A:CYS39 3.7 0.0 1.0 CB A:CYS36 3.7 0.0 1.0 HB3 A:CYS36 3.8 0.0 1.0 CB A:CYS66 3.8 0.0 1.0 N A:CYS39 3.8 0.0 1.0 HB2 A:CYS36 3.9 0.0 1.0 HB3 A:CYS66 3.9 0.0 1.0 N A:CYS66 3.9 0.0 1.0 HB3 A:CYS69 4.0 0.0 1.0 HB2 A:ASN38 4.0 0.0 1.0 HE2 A:PHE43 4.1 0.0 1.0 H A:CYS69 4.2 0.0 1.0 H A:ASN38 4.3 0.0 1.0 HA A:VAL65 4.3 0.0 1.0 CA A:CYS39 4.4 0.0 1.0 CG A:ASN38 4.4 0.0 1.0 CA A:CYS66 4.5 0.0 1.0 C A:ASN38 4.5 0.0 1.0 HB A:VAL65 4.5 0.0 1.0 CA A:ASN38 4.5 0.0 1.0 CA A:CYS69 4.5 0.0 1.0 HB3 A:CYS39 4.5 0.0 1.0 N A:CYS69 4.6 0.0 1.0 HB2 A:CYS66 4.6 0.0 1.0 N A:ASN38 4.8 0.0 1.0 HD22 A:ASN38 4.8 0.0 1.0 O A:CYS66 4.8 0.0 1.0 HA A:CYS69 4.9 0.0 1.0 H A:GLY40 4.9 0.0 1.0 CE2 A:PHE43 4.9 0.0 1.0 ND2 A:ASN38 4.9 0.0 1.0 OD1 A:ASN38 5.0 0.0 1.0 C A:VAL65 5.0 0.0 1.0 HB3 A:ASN68 5.0 0.0 1.0

E.F.Reinhart, N.A.Litt, S.Katzenell, M.Pellegrini, A.Yamamoto, M.J.Ragusa. A Highly Conserved Glutamic Acid in Alfy Inhibits Membrane Binding to Aid in Aggregate Clearance. Traffic 2020.
ISSN: ESSN 1600-0854
PubMed: 33225481
DOI: 10.1111/TRA.12771