Zinc in PDB 6w9c: The Crystal Structure of Papain-Like Protease of Sars Cov-2

The structure of The Crystal Structure of Papain-Like Protease of Sars Cov-2, PDB code: 6w9c was solved by J.Osipiuk, R.Jedrzejczak, C.Tesar, M.Endres, L.Stols, G.Babnigg, Y.Kim, K.Michalska, A.Joachimiak, Center For Structural Genomics Ofinfectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.68 / 2.70
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	190.786, 110.280, 64.069, 90.00, 96.22, 90.00
R / Rfree (%)	23.5 / 30.9

The structure of The Crystal Structure of Papain-Like Protease of Sars Cov-2 also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Zinc atom in the The Crystal Structure of Papain-Like Protease of Sars Cov-2 (pdb code 6w9c). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the The Crystal Structure of Papain-Like Protease of Sars Cov-2, PDB code: 6w9c:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the The Crystal Structure of Papain-Like Protease of Sars Cov-2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Crystal Structure of Papain-Like Protease of Sars Cov-2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn501 b:99.6 occ:1.00 SG B:CYS192 2.7 0.4 1.0 SG B:CYS189 2.8 92.2 1.0 CB B:CYS189 3.3 91.4 1.0 CB B:CYS192 4.1 1.0 1.0 O B:GLN229 4.3 76.3 1.0 N B:CYS192 4.7 0.2 1.0 CA B:CYS189 4.8 90.9 1.0 O B:PRO223 4.9 97.1 1.0

Zinc binding site 2 out of 3 in the The Crystal Structure of Papain-Like Protease of Sars Cov-2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of The Crystal Structure of Papain-Like Protease of Sars Cov-2 within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn401 b:65.7 occ:1.00 CB C:CYS270 2.3 52.2 1.0 SG C:CYS270 2.4 53.1 1.0 SG B:CYS270 2.4 45.4 1.0 CB B:CYS270 2.6 45.1 1.0 SG A:CYS270 2.8 46.2 1.0 CA C:CYS270 3.4 51.1 1.0 CB A:CYS270 3.6 45.1 1.0 CA A:CYS270 3.7 44.6 1.0 N C:CYS270 3.9 51.7 1.0 O A:GLN269 3.9 45.9 1.0 CA B:CYS270 4.0 44.1 1.0 N A:CYS270 4.1 45.7 1.0 C A:GLN269 4.3 46.1 1.0 OE1 C:GLN269 4.4 54.5 1.0 N B:CYS270 4.4 44.8 1.0 CG C:GLN269 4.4 53.3 1.0 C C:GLN269 4.6 51.8 1.0 O B:GLN269 4.7 45.4 1.0 C C:CYS270 4.7 50.4 1.0 CD C:GLN269 4.7 54.3 1.0 C B:GLN269 4.8 45.6 1.0 O C:GLN269 4.8 51.8 1.0 O C:CYS270 4.9 50.9 1.0

Zinc binding site 3 out of 3 in the The Crystal Structure of Papain-Like Protease of Sars Cov-2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of The Crystal Structure of Papain-Like Protease of Sars Cov-2 within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn402 b:0.2 occ:1.00 SG C:CYS224 2.2 0.6 1.0 SG C:CYS189 2.8 89.8 1.0 SG C:CYS226 2.9 0.9 1.0 CB C:CYS224 2.9 0.7 1.0 CB C:CYS189 3.2 89.4 1.0 CB C:CYS226 3.8 0.8 1.0 CB C:CYS192 3.9 95.4 1.0 N C:CYS192 3.9 96.2 1.0 SG C:CYS192 4.0 98.6 1.0 CB C:THR191 4.1 99.3 1.0 CA C:CYS224 4.4 0.8 1.0 CA C:CYS192 4.5 95.7 1.0 N C:CYS226 4.6 0.4 1.0 OG1 C:THR191 4.6 99.3 1.0 CA C:CYS189 4.7 89.0 1.0 CA C:CYS226 4.7 0.4 1.0 CB C:LYS228 4.7 0.3 1.0 N C:THR191 4.8 96.6 1.0 CA C:THR191 4.8 98.8 1.0 C C:THR191 4.8 98.5 1.0 CG2 C:THR191 4.9 0.5 1.0

J.Osipiuk, R.Jedrzejczak, C.Tesar, M.Endres, L.Stols, G.Babnigg, Y.Kim, K.Michalska, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid). The Crystal Structure of Papain-Like Protease of Sars Cov-2 To Be Published.