Zinc in PDB 6r8f: Cryo-Em Structure of the Human Brisc-SHMT2 Complex

All present enzymatic activity of Cryo-Em Structure of the Human Brisc-SHMT2 Complex:
2.1.2.1;

The binding sites of Zinc atom in the Cryo-Em Structure of the Human Brisc-SHMT2 Complex (pdb code 6r8f). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Cryo-Em Structure of the Human Brisc-SHMT2 Complex, PDB code: 6r8f:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Cryo-Em Structure of the Human Brisc-SHMT2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of the Human Brisc-SHMT2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:66.6 occ:1.00 OD2 A:ASP135 2.1 48.1 1.0 NE2 A:HIS124 2.1 31.9 1.0 OD1 A:ASP135 2.1 48.1 1.0 NE2 A:HIS122 2.2 31.7 1.0 CG A:ASP135 2.3 48.1 1.0 CD2 A:HIS122 2.7 31.7 1.0 CE1 A:HIS124 3.0 31.9 1.0 CD2 A:HIS124 3.1 31.9 1.0 CE1 A:HIS122 3.3 31.7 1.0 CB A:ASP135 3.8 48.1 1.0 OE1 A:GLU33 3.9 45.6 1.0 CG A:HIS122 4.0 31.7 1.0 CB A:ARG89 4.1 57.7 1.0 ND1 A:HIS124 4.2 31.9 1.0 ND1 A:HIS122 4.2 31.7 1.0 CG A:HIS124 4.2 31.9 1.0 CD A:GLU33 4.6 45.6 1.0 CA A:ASP135 4.7 48.1 1.0 OE2 A:GLU33 4.8 45.6 1.0 CD1 A:ILE153 5.0 27.4 1.0

Zinc binding site 2 out of 2 in the Cryo-Em Structure of the Human Brisc-SHMT2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of the Human Brisc-SHMT2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn401 b:81.3 occ:1.00 OD1 C:ASP135 2.1 62.9 1.0 NE2 C:HIS124 2.1 41.8 1.0 OD2 C:ASP135 2.1 62.9 1.0 NE2 C:HIS122 2.1 39.8 1.0 CG C:ASP135 2.3 62.9 1.0 CD2 C:HIS122 2.7 39.8 1.0 CE1 C:HIS124 3.1 41.8 1.0 CD2 C:HIS124 3.1 41.8 1.0 CE1 C:HIS122 3.2 39.8 1.0 CB C:ASP135 3.8 62.9 1.0 CG C:HIS122 3.9 39.8 1.0 OE1 C:GLU33 3.9 57.0 1.0 CB C:ARG89 4.1 67.0 1.0 ND1 C:HIS122 4.1 39.8 1.0 ND1 C:HIS124 4.2 41.8 1.0 CG C:HIS124 4.2 41.8 1.0 CD C:GLU33 4.6 57.0 1.0 CA C:ASP135 4.8 62.9 1.0 OE2 C:GLU33 4.8 57.0 1.0 CD1 C:ILE153 4.9 34.1 1.0

M.Walden, L.Tian, R.L.Ross, U.M.Sykora, D.P.Byrne, E.L.Hesketh, S.K.Masandi, J.Cassel, R.George, J.R.Ault, F.El Oualid, K.Pawlowski, J.M.Salvino, P.A.Eyers, N.A.Ranson, F.Del Galdo, R.A.Greenberg, E.Zeqiraj. Metabolic Control of Brisc-SHMT2 Assembly Regulates Immune Signalling. Nature V. 570 194 2019.
ISSN: ESSN 1476-4687
PubMed: 31142841
DOI: 10.1038/S41586-019-1232-1