Atomistry » Zinc » PDB 6puz-6qch » 6q8c
Atomistry »
  Zinc »
    PDB 6puz-6qch »
      6q8c »

Zinc in PDB 6q8c: Neisseria Gonorrhoeae Leucyl-Trna Synthetase in Complex with 5'-O-(N- (L-Leucyl)-Sulfamoyl)Uridine

Enzymatic activity of Neisseria Gonorrhoeae Leucyl-Trna Synthetase in Complex with 5'-O-(N- (L-Leucyl)-Sulfamoyl)Uridine

All present enzymatic activity of Neisseria Gonorrhoeae Leucyl-Trna Synthetase in Complex with 5'-O-(N- (L-Leucyl)-Sulfamoyl)Uridine:
6.1.1.4;

Protein crystallography data

The structure of Neisseria Gonorrhoeae Leucyl-Trna Synthetase in Complex with 5'-O-(N- (L-Leucyl)-Sulfamoyl)Uridine, PDB code: 6q8c was solved by L.Pang, S.De Graef, S.V.Strelkov, S.D.Weeks, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 113.86 / 2.31
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 49.321, 82.001, 227.725, 90.00, 90.00, 90.00
R / Rfree (%) 20 / 25.1

Other elements in 6q8c:

The structure of Neisseria Gonorrhoeae Leucyl-Trna Synthetase in Complex with 5'-O-(N- (L-Leucyl)-Sulfamoyl)Uridine also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Neisseria Gonorrhoeae Leucyl-Trna Synthetase in Complex with 5'-O-(N- (L-Leucyl)-Sulfamoyl)Uridine (pdb code 6q8c). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Neisseria Gonorrhoeae Leucyl-Trna Synthetase in Complex with 5'-O-(N- (L-Leucyl)-Sulfamoyl)Uridine, PDB code: 6q8c:

Zinc binding site 1 out of 1 in 6q8c

Go back to Zinc Binding Sites List in 6q8c
Zinc binding site 1 out of 1 in the Neisseria Gonorrhoeae Leucyl-Trna Synthetase in Complex with 5'-O-(N- (L-Leucyl)-Sulfamoyl)Uridine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Neisseria Gonorrhoeae Leucyl-Trna Synthetase in Complex with 5'-O-(N- (L-Leucyl)-Sulfamoyl)Uridine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn902

b:50.1
occ:1.00
 SG A:CYS452 2.2 53.3 1.0
SG A:CYS449 2.3 49.9 1.0
SG A:CYS493 2.4 50.4 1.0
SG A:CYS490 2.4 50.8 1.0
CB A:CYS490 3.1 45.6 1.0
CB A:CYS452 3.3 50.7 1.0
CB A:CYS449 3.3 48.0 1.0
CB A:CYS493 3.4 43.6 1.0
N A:CYS493 3.7 43.0 1.0
N A:CYS452 3.9 51.4 1.0
CA A:CYS493 4.1 57.1 1.0
CA A:CYS452 4.2 50.9 1.0
CB A:LYS451 4.4 67.1 1.0
CB A:CYS492 4.5 43.9 1.0
CA A:CYS490 4.6 43.5 1.0
O A:HOH1015 4.7 51.3 1.0
C A:CYS492 4.7 55.6 1.0
CA A:CYS449 4.8 45.8 1.0
C A:CYS493 4.8 51.6 1.0
N A:GLY494 4.8 48.6 1.0
C A:LYS451 4.8 58.3 1.0
N A:LYS451 4.9 67.3 1.0
CA A:LYS451 5.0 67.5 1.0
CA A:CYS492 5.0 44.2 1.0
N A:GLY495 5.0 44.0 1.0

Reference:

M.Nautiyal, S.De Graef, L.Pang, B.Gadakh, S.V.Strelkov, S.D.Weeks, A.Van Aerschot. Comparative Analysis of Pyrimidine Substituted Aminoacyl-Sulfamoyl Nucleosides As Potential Inhibitors Targeting Class I Aminoacyl-Trna Synthetases. Eur.J.Med.Chem. V. 173 154 2019.
ISSN: ISSN 0223-5234
PubMed: 30995568
DOI: 10.1016/J.EJMECH.2019.04.003
Page generated: Tue Oct 29 05:32:04 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy