Zinc in PDB 6o7g: Solution Structure of MLL4 PHD6 Domain in Complex with Histone H4K16AC Peptide

All present enzymatic activity of Solution Structure of MLL4 PHD6 Domain in Complex with Histone H4K16AC Peptide:
2.1.1.43;

The binding sites of Zinc atom in the Solution Structure of MLL4 PHD6 Domain in Complex with Histone H4K16AC Peptide (pdb code 6o7g). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Solution Structure of MLL4 PHD6 Domain in Complex with Histone H4K16AC Peptide, PDB code: 6o7g:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Solution Structure of MLL4 PHD6 Domain in Complex with Histone H4K16AC Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Solution Structure of MLL4 PHD6 Domain in Complex with Histone H4K16AC Peptide within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1601 b:0.0 occ:1.00 ND1 B:HIS1531 2.3 0.0 1.0 SG B:CYS1507 2.4 0.0 1.0 SG B:CYS1534 2.4 0.0 1.0 SG B:CYS1510 2.4 0.0 1.0 H B:HIS1531 3.0 0.0 1.0 HB3 B:CYS1534 3.2 0.0 1.0 CE1 B:HIS1531 3.2 0.0 1.0 HB2 B:CYS1510 3.3 0.0 1.0 HE1 B:HIS1531 3.3 0.0 1.0 HB2 B:HIS1531 3.3 0.0 1.0 HB B:ILE1509 3.3 0.0 1.0 CB B:CYS1534 3.3 0.0 1.0 H B:CYS1510 3.3 0.0 1.0 CG B:HIS1531 3.4 0.0 1.0 CB B:CYS1507 3.4 0.0 1.0 HB3 B:CYS1507 3.4 0.0 1.0 CB B:CYS1510 3.4 0.0 1.0 HB2 B:CYS1507 3.6 0.0 1.0 HB2 B:CYS1534 3.7 0.0 1.0 CB B:HIS1531 3.8 0.0 1.0 N B:CYS1510 3.9 0.0 1.0 N B:HIS1531 3.9 0.0 1.0 HB2 B:MET1530 4.1 0.0 1.0 HB3 B:CYS1510 4.3 0.0 1.0 CA B:CYS1510 4.3 0.0 1.0 H B:CYS1534 4.3 0.0 1.0 HD13 B:ILE1509 4.3 0.0 1.0 NE2 B:HIS1531 4.4 0.0 1.0 CB B:ILE1509 4.4 0.0 1.0 HA B:MET1530 4.4 0.0 1.0 CA B:HIS1531 4.5 0.0 1.0 CD2 B:HIS1531 4.5 0.0 1.0 H B:ILE1509 4.6 0.0 1.0 C B:ILE1509 4.7 0.0 1.0 HG13 B:ILE1509 4.7 0.0 1.0 HA B:CYS1510 4.7 0.0 1.0 CA B:CYS1507 4.7 0.0 1.0 CA B:CYS1534 4.7 0.0 1.0 HB3 B:HIS1531 4.8 0.0 1.0 N B:CYS1534 4.9 0.0 1.0 C B:MET1530 4.9 0.0 1.0 CA B:ILE1509 5.0 0.0 1.0 CG1 B:ILE1509 5.0 0.0 1.0 HA B:CYS1507 5.0 0.0 1.0

Zinc binding site 2 out of 2 in the Solution Structure of MLL4 PHD6 Domain in Complex with Histone H4K16AC Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Solution Structure of MLL4 PHD6 Domain in Complex with Histone H4K16AC Peptide within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1602 b:0.0 occ:1.00 SG B:CYS1556 2.4 0.0 1.0 SG B:CYS1526 2.4 0.0 1.0 SG B:CYS1553 2.5 0.0 1.0 SG B:CYS1523 2.5 0.0 1.0 H B:CYS1553 2.8 0.0 1.0 HB2 B:CYS1526 3.0 0.0 1.0 HB2 B:CYS1556 3.1 0.0 1.0 H B:CYS1526 3.2 0.0 1.0 HB3 B:HIS1525 3.3 0.0 1.0 CB B:CYS1526 3.3 0.0 1.0 CB B:CYS1556 3.3 0.0 1.0 HB3 B:CYS1553 3.5 0.0 1.0 CB B:CYS1523 3.5 0.0 1.0 CB B:CYS1553 3.5 0.0 1.0 HB2 B:CYS1523 3.5 0.0 1.0 HB3 B:CYS1523 3.6 0.0 1.0 N B:CYS1553 3.7 0.0 1.0 HD2 B:HIS1525 3.9 0.0 1.0 HB3 B:CYS1556 4.0 0.0 1.0 N B:CYS1526 4.0 0.0 1.0 H B:CYS1556 4.0 0.0 1.0 CA B:CYS1553 4.1 0.0 1.0 HB3 B:CYS1526 4.1 0.0 1.0 HA B:ASP1552 4.3 0.0 1.0 CA B:CYS1526 4.4 0.0 1.0 H B:HIS1525 4.4 0.0 1.0 CB B:HIS1525 4.4 0.0 1.0 HB2 B:CYS1553 4.4 0.0 1.0 N B:CYS1556 4.5 0.0 1.0 CA B:CYS1556 4.5 0.0 1.0 HB2 B:SER1555 4.6 0.0 1.0 C B:CYS1553 4.7 0.0 1.0 CD2 B:HIS1525 4.8 0.0 1.0 C B:ASP1552 4.8 0.0 1.0 HA B:CYS1556 4.8 0.0 1.0 HB3 B:ASP1552 4.9 0.0 1.0 CA B:CYS1523 4.9 0.0 1.0 C B:HIS1525 4.9 0.0 1.0 HB2 B:HIS1525 4.9 0.0 1.0 O B:CYS1553 4.9 0.0 1.0 HA B:CYS1526 4.9 0.0 1.0

Y.Zhang, Y.Jang, J.E.Lee, J.Ahn, L.Xu, M.R.Holden, E.M.Cornett, K.Krajewski, B.J.Klein, S.P.Wang, Y.Dou, R.G.Roeder, B.D.Strahl, S.B.Rothbart, X.Shi, K.Ge, T.G.Kutateladze. Selective Binding of the PHD6 Finger of MLL4 to Histone H4K16AC Links MLL4 and Mof. Nat Commun V. 10 2314 2019.
ISSN: ESSN 2041-1723
PubMed: 31127101
DOI: 10.1038/S41467-019-10324-8