Zinc in PDB 6lxd: Pri-Mirna Bound Drosha-DGCR8 Complex

All present enzymatic activity of Pri-Mirna Bound Drosha-DGCR8 Complex:
3.1.26.3;

The binding sites of Zinc atom in the Pri-Mirna Bound Drosha-DGCR8 Complex (pdb code 6lxd). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Pri-Mirna Bound Drosha-DGCR8 Complex, PDB code: 6lxd:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Pri-Mirna Bound Drosha-DGCR8 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Pri-Mirna Bound Drosha-DGCR8 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1401 b:0.5 occ:1.00 CE1 A:HIS609 2.3 0.5 1.0 CE1 A:HIS680 2.3 0.5 1.0 SG A:CYS676 2.4 0.5 1.0 SG A:CYS561 2.6 0.5 1.0 NE2 A:HIS609 2.8 0.5 1.0 NE2 A:HIS680 2.8 0.5 1.0 ND1 A:HIS609 3.5 0.5 1.0 ND1 A:HIS680 3.5 0.5 1.0 CB A:CYS676 4.0 0.5 1.0 CD2 A:HIS609 4.1 0.5 1.0 CD2 A:HIS680 4.1 0.5 1.0 CB A:CYS561 4.4 0.5 1.0 CG A:HIS609 4.4 0.5 1.0 CG A:HIS680 4.5 0.5 1.0 CD2 A:LEU571 4.5 0.5 1.0 O A:PRO677 4.5 0.5 1.0 N A:CYS561 4.5 0.5 1.0 CG2 A:VAL642 4.7 0.5 1.0

Zinc binding site 2 out of 2 in the Pri-Mirna Bound Drosha-DGCR8 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Pri-Mirna Bound Drosha-DGCR8 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1402 b:1.0 occ:1.00 NE2 A:HIS1026 2.1 1.0 1.0 CE1 A:HIS549 2.4 0.5 1.0 SG A:CYS536 2.4 0.0 1.0 SG A:CYS538 2.7 0.9 1.0 NE2 A:HIS549 2.7 0.5 1.0 CD2 A:HIS1026 2.8 1.0 1.0 CE1 A:HIS1026 3.1 1.0 1.0 CB A:CYS538 3.4 0.9 1.0 ND1 A:HIS549 3.6 0.5 1.0 CB A:CYS536 3.9 0.0 1.0 CG A:HIS1026 3.9 1.0 1.0 ND1 A:HIS1026 4.0 1.0 1.0 NE A:ARG548 4.0 0.5 1.0 CD2 A:HIS549 4.0 0.5 1.0 N A:CYS538 4.2 0.9 1.0 CA A:CYS536 4.3 0.0 1.0 CA A:CYS538 4.4 0.9 1.0 CG A:HIS549 4.5 0.5 1.0 N A:LYS537 4.6 0.1 1.0 CD A:ARG548 4.7 0.5 1.0 CG A:ARG543 4.7 0.8 1.0 C A:CYS536 4.8 0.0 1.0 NH1 A:ARG548 4.8 0.5 1.0 CZ A:ARG548 4.9 0.5 1.0

W.Jin, J.Wang, C.P.Liu, H.W.Wang, R.M.Xu. Structural Basis For Pri-Mirna Recognition By Drosha. Mol.Cell 2020.
ISSN: ISSN 1097-2765
PubMed: 32220645
DOI: 10.1016/J.MOLCEL.2020.02.024