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Zinc in PDB 6iji: Crystal Structure of PDE10 in Complex with Inhibitor 2BEnzymatic activity of Crystal Structure of PDE10 in Complex with Inhibitor 2B
All present enzymatic activity of Crystal Structure of PDE10 in Complex with Inhibitor 2B:
3.1.4.17; 3.1.4.35; Protein crystallography data
The structure of Crystal Structure of PDE10 in Complex with Inhibitor 2B, PDB code: 6iji
was solved by
Y.Y.Huang,
Y.F.Yu,
C.Zhang,
D.Wu,
Y.Wu,
H.B.Luo,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6iji:
The structure of Crystal Structure of PDE10 in Complex with Inhibitor 2B also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of PDE10 in Complex with Inhibitor 2B
(pdb code 6iji). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of PDE10 in Complex with Inhibitor 2B, PDB code: 6iji: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 6ijiGo back to Zinc Binding Sites List in 6iji
Zinc binding site 1 out
of 2 in the Crystal Structure of PDE10 in Complex with Inhibitor 2B
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 6ijiGo back to Zinc Binding Sites List in 6iji
Zinc binding site 2 out
of 2 in the Crystal Structure of PDE10 in Complex with Inhibitor 2B
Mono view Stereo pair view
Reference:
Y.Y.Huang,
Y.F.Yu,
C.Zhang,
Y.Chen,
Q.Zhou,
Z.Li,
S.Zhou,
Z.Li,
L.Guo,
D.Wu,
Y.Wu,
H.B.Luo.
Validation of Phosphodiesterase-10 As A Novel Target For Pulmonary Arterial Hypertension Via Highly Selective and Subnanomolar Inhibitors. J. Med. Chem. V. 62 3707 2019.
Page generated: Wed Dec 16 12:00:43 2020
ISSN: ISSN 1520-4804 PubMed: 30888810 DOI: 10.1021/ACS.JMEDCHEM.9B00224 |
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